Results 171 to 180 of about 224,441 (293)

Genetic Screening of Familial Hypercholesterolemia in Portugal

, 2015
Purpose: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder of lipid metabolism (1:500 frequency), caused by mutations in LDLR, APOB, PCSK9 genes.
Alves, A.C., Bourbon, Mafalda, Medeiros, A.M.   +2 more
core  

Evaluating the Impact on Adult Caregivers of Family‐Based Treatment for Childhood Obesity

Obesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Background Weight management in children involves family lifestyle changes and relies on caregivers of children to implement these changes at home. Little is known about the effects of family‐based lifestyle intervention programs for children on caregivers themselves when not specifically targeted by the intervention.
Paola Luca, Amy Bobyn, Grace P. S. Kwong, Alberto Nettel‐Aguirre, Ronald Sigal, Emma O. Billington, Raylene A. Reimer, Josephine Ho   +7 more
wiley   +1 more source

Understanding Barriers and Motivators of Familial Hypercholesterolemia Genetic Testing: Insights From the Singapore Public. [PDF]

J Genet Couns
Quek DSR, Yin R, Chan FHF, Nastar A, Ngeow J, Pek S, Savulescu J, Subramaniam T, Griva K.   +8 more
europepmc   +1 more source

Family Dynamics and Longitudinal Trends in Pediatric Obesity: A Real‐World Observational Study in a Public Outpatient Clinic

Obesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Background Childhood obesity remains a major public health challenge, and evidence on the outcomes of routine multidisciplinary care in real‐world clinical settings remains limited. This study evaluated longitudinal changes in BMI z‐score and lifestyle behaviors among children and adolescents with obesity and their caregivers receiving ...
Fábio de Freitas, Mirella Menaque da Paz, Mariana R. Zago, Marcia Regina Vitolo, Maria Ângela Antônio, Maria Ângela Bellomo Brandão   +5 more
wiley   +1 more source

Pubertal Timing Associates With Cardiometabolic Markers During Puberty and in Young Adulthood

Acta Paediatrica, Volume 115, Issue 10, Page 2168-2190, October 2026.
ABSTRACT Aim To study how pubertal timing associates with cardiometabolic measures in puberty and young adulthood. Methods Cardiovascular risk factors, anthropometry and pubertal development were regularly studied in STRIP study subjects until age 26 years.
Saga Nummela, Katja Pahkala, Sinikka Karppinen, Jorma Toppari, Olli Raitakari, Jorma Viikari, Tapani Rönnemaa, Harri Niinikoski   +7 more
wiley   +1 more source

Carpe Diem: Genetic Testing for Familial Hypercholesterolemia From Acute Coronary Care to the Community. [PDF]

JACC Adv
Pang J, Rosenson RS, Wilkinson MJ, Kalra DK, Watts GF.   +4 more
europepmc   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Proposal of a familial hypercholesterolemia paediatric diagnostic score (FH-PeDS). [PDF]

Eur J Prev Cardiol
Kafol J, Miranda B, Sikonja R, Sikonja J, Wiegman A, Medeiros AM, Alves AC, Freiberger T, Hutten BA, Mlinaric M, Battelino T, Humphries SE, Bourbon M, Groselj U.   +13 more
europepmc   +1 more source

Clinical and Genetic Profile of One Molecularly Confirmed and One Clinically Suspected Case of LZTR1 ‐Related Noonan Syndrome

Clinical Genetics, Volume 110, Issue 4, Page 502-507, October 2026.
This study illustrates the phenotypic variability of LZTR1‐related Noonan syndrome type 10 in two pediatric patients, including presentations without congenital heart defects. The findings emphasize the importance of whole‐exome sequencing and longitudinal re‐evaluation of variants of uncertain significance in achieving accurate diagnosis.
Karolina Skrzyńska, Barbara Kalina‐Faska, Ewa Błaszczyk, Aneta Gawlik‐Starzyk   +3 more
wiley   +1 more source

Extracellular vesicles related to familial hypercholesterolemia. [PDF]

Arch Endocrinol Metab
Silvino JPP, Jannes CE, Pestana RMC, Silvino LPP, Silva IFO, Teixeira-Carvalho A, Gomes KB.   +6 more
europepmc   +1 more source