Results 171 to 180 of about 340,370 (339)

Cost-effectiveness analysis of the genetic screening program for familial hypercholesterolemia in The Netherlands.

, 2004
Familial hypercholesterolemia (FH) is associated with pronounced atherosclerosis leading to premature cardiovascular disease and untimely death. Despite the availability of effective preventative drug treatments, many affected individuals remain ...
Umans-Eckenhausen, Marina A. W., David Wonderling, Margaret Thorogood, Wonderling, David, Kastelein, John JP, Thorogood, Margaret, Marina Umans-Eckenhausen, Defesche, Joep C., Joep Defesche, Umans-Eckenhausen, Marina AW, Defesche, Joep C, Marks, Dalya, John Kastelein, Kastelein, John J. P., Dalya Marks   +14 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Genes Potentially Associated with Familial Hypercholesterolemia

, 2019
This review addresses the contribution of some genes to the phenotype of familial hypercholesterolemia. At present, it is known that the pathogenesis of this disease involves not only a pathological variant of low-density lipoprotein receptor and its ...
Svetlana Mikhailova, Dinara Ivanoshchuk, Elena Shakhtshneider, Olga Timoshchenko   +3 more
core   +1 more source

Pubertal Timing Associates With Cardiometabolic Markers During Puberty and in Young Adulthood

Acta Paediatrica, EarlyView.
ABSTRACT Aim To study how pubertal timing associates with cardiometabolic measures in puberty and young adulthood. Methods Cardiovascular risk factors, anthropometry and pubertal development were regularly studied in STRIP study subjects until age 26 years.
Saga Nummela, Katja Pahkala, Sinikka Karppinen, Jorma Toppari, Olli Raitakari, Jorma Viikari, Tapani Rönnemaa, Harri Niinikoski   +7 more
wiley   +1 more source

The family hypercholesterolemia

Medical Journal of the Russian Federation, 2016
The family hypercholesterolemia is among causes of premature development of cardiovascular diseases in patients of young age. At this disease, high level of cholesterol of lipoproteins of low density are registered and family anamnesis is traced. However, nowadays there is no unified international criterion for diagnostic of hypercholesterolemia.
openaire   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Risk of brain infarction in familial hypercholesterolemia.

, 1988
We followed 54 subjects with heterozygous familial hypercholesterolemia for an average of 10 (range 3-14) years. Half were treated surgically with partial ileal bypass and the other half (matched for age, sex, coronary heart disease, blood pressure ...
M Kaste, P Koivisto
core   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Rheumatoid-like hand deformities and aortic valve disease in a 13-year-old girl with homozygous familial hypercholesterolemia: a case report

Journal of Medical Case Reports
Background Familial hypercholesterolemia is an autosomal dominant disorder characterized by elevated serum low-density lipoprotein cholesterol levels, tendon xanthomas, and an increased risk of atherosclerotic heart disease.
Anjuman Ara Rahman, Abhijit Datta, Kamal Uddin Ahmed, Anindita Das Barshan, Mohammad Jahid Hasan   +4 more
doaj   +1 more source

Life Course Approach for Managing Familial Hypercholesterolemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Treatment of familial hypercholesterolemia is directed toward the moment of the medical encounter. However, risk for heart disease as a consequence of having familial hypercholesterolemia is related to lifelong exposure to elevated low‐density ...
Samuel S. Gidding, Dirk J. Blom, Brian McCrindle, Uma Ramaswami, Raul D. Santos, Gerald F. Watts, Albert Wiegman   +6 more
doaj   +1 more source