Results 141 to 150 of about 20,467 (242)

A Genome-First Study of Familial Hypercholesterolemia Comparing African and European Ancestry Individuals. [PDF]

Circulation
Winters AH, Kelly MA, Syed MG, Bergquist T, Berry ASF, Mohammed N, Cawley D, Jones LK, Pejaver V, Gidding SS, Oetjens MT.   +10 more
europepmc   +1 more source

Genetic Counseling in Aotearoa New Zealand: Context, Practice and the Future of Genomic Healthcare

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
ABSTRACT Genetic counselors have been practicing in Aotearoa New Zealand since 1995, and are now established across both public and private sectors of healthcare. While significant global efforts have been made to define the profession of genetic counseling, the distinct way in which genetic counselors practice in New Zealand has not been formally ...
Elisha Swainson, Harry G. Fraser, Linda L. Cheng, Sarah Collis, Alice Christian, Kimberley Gamet, Alison McEwen   +6 more
wiley   +1 more source

Aortic Stenosis in Homozygous Familial Hypercholesterolemia: The Canadian HoFH Registry. [PDF]

JACC Adv
Erzingatzian A, Al-Baldawi Z, Ruel I, Brown L, Sherman MH, Laflamme N, Bergeron J, Couture P, Paquette M, Baass A, Brisson D, Larouche M, Gaudet D, Cermakova L, Wan D, Brunham LR, Francis GA, Mancini GBJ, Kennedy BA, Hegele RA, Lewis GF, McCrindle BW, Ransom T, McPherson R, Piazza N, de Varennes B, Genest J, Iatan I.   +27 more
europepmc   +1 more source

Safety and Efficacy of Aumolertinib as First‐Line Treatment in EGFR‐Mutant Lung Adenosquamous Carcinoma: A Multicenter, Single‐Arm, Prospective Phase II Study (ARISE Study)

MedComm, Volume 7, Issue 8, August 2026.
Aumolertinib treatment resulted in improved clinical activity in EGFR‐mutant ASC. ABSTRACT Lung adenosquamous carcinoma (ASC) is a rare histological subtype of non‐small cell lung cancer (NSCLC), and prospective data regarding the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in this patient population remain ...
Longfeng Zhang, Long Huang, Dingzhi Huang, Zhe Liu, Yongfeng Yu, Kang Miao, Qian Miao, Xiaobin Zheng, Yiquan Xu, Qian Chu, Gen Lin   +10 more
wiley   +1 more source

Familial Hypercholesterolemia: Still an Enigma. [PDF]

JACC Case Rep
Arora S, Kharsa A, Sharma G.
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Non-Responder to Inclisiran and Evolocumab-A Female Patient with Heterozygous Familial Hypercholesterolemia and Statin Intolerance. [PDF]

Diseases
Muszyński P, Chlabicz M, Kruszyńska J, Wilk-Śledziewska K, Kazberuk P, Musiałowska D, Groth M, Dudzińska K.   +7 more
europepmc   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong, Zaiyong Zheng, Min Huang, Shengyu Huang, Xingwei Zhao, Yang Yu, Chunxiang Zhang   +6 more
wiley   +1 more source

Clinical and Molecular Genetic Risk Factors for Severe Familial Hypercholesterolemia. [PDF]

J Lipid Atheroscler
Rho EH, Kang Y, Yoon M, Son NH, Choi SH, Lee SH, Park KS, Kwak SH, Korean Familial Hypercholesterolemia (KFH) Registry Investigators.   +8 more
europepmc   +1 more source

Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy

Optometry and Vision Science, Volume 103, Issue 8, August 2026.
ABSTRACT Purpose To highlight retinal ischemia as an important component of diabetic retinopathy (DR) pathogenesis, a significant prognostic factor, and a driver of various DR complications, including neovascularization. We aim to describe the main features of ischemic areas that can be identified through fundoscopy, color fundus photography, optical ...
Marina Guro, Henrietta Wang, Jack Phu, Kaitlyn A. Sapoznik, Hamza Shah, Maggie L. Zhang, Michael Kalloniatis   +6 more
wiley   +1 more source