Results 1 to 10 of about 7,414 (159)

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M [PDF]

Nature Genetics, 2005
Fanconi anemia is a genetic disease characterized by genomic instability and cancer predisposition. Nine genes involved in Fanconi anemia have been identified; their products participate in a DNA damage-response network involving BRCA1 and BRCA2 (refs. 2,3).
Meetei, A R, Medhurst, Al, Ling, C, Xue, Y, Singh, T R, Bier, P, Steltenpool, J, Stone, S, Dokal, I, Mathew, C G, Hoatlin, M, Joenje, H, de Winter, J P, Wang, W   +13 more
openaire   +6 more sources

FANCD2 as a novel prognostic biomarker correlated with immune and drug therapy in Hepatitis B-related hepatocellular carcinoma

European Journal of Medical Research, 2023
Background Ferroptosis is related to the immunosuppression of tumors and plays a critical role in cancer progression. Fanconi anemia complementation group D2 (FANCD2) is a vital gene that regulates ferroptosis.
Xiaowei Tang, Bei Luo, Shu Huang, Jiao Jiang, Yuan Chen, Wensen Ren, Xiaomin Shi, Wei Zhang, Lei Shi, Xiaolin Zhong, Muhan Lü   +10 more
doaj   +1 more source

Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction [PDF]

Cancer Research, 2009
Abstract Fanconi anemia is a cancer-prone inherited bone marrow failure and cancer susceptibility syndrome with at least 13 complementation groups (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, and FANCN).
Gang, Zhi, James B, Wilson, Xiaoyong, Chen, Diane S, Krause, Yuxuan, Xiao, Nigel J, Jones, Gary M, Kupfer   +6 more
openaire   +2 more sources

Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein [PDF]

Nucleic Acids Research, 2013
MUS81-EME1 is a DNA endonuclease involved in replication-coupled repair of DNA interstrand cross-links (ICLs). A prevalent hypothetical role of MUS81-EME1 in ICL repair is to unhook the damage by incising the leading strand at the 3' side of an ICL lesion.
Benitez, Anaid, Yuan, Fenghua, Nakajima, Satoshi, Wei, Leizhen, Qian, Liangyue, Myers, Richard, Hu, Jennifer J., Lan, Li, Zhang, Yanbin   +8 more
openaire   +2 more sources

Advances in the Understanding of Fanconi Anemia Complementation Group D2 Protein (FANCD2) in Human Cancer [PDF]

Cancer Cell & Microenvironment, 2015
Fanconi anemia (FA) is a rare human genetic disease, resulting from dysfunction in any of 17 known complementation proteins: FANC-A, B, C, D1, D2, E, F, G, I, J, L, M, N, O, P, Q & S, and other unknowns. Besides the severe bone marrow failure, an extremely high incidence of cancer as well as many other clinic symptoms associated with FA patients, FA ...
Yihang, Shen, Jun, Zhang, Herbert, Yu, Peiwen, Fei   +3 more
openaire   +2 more sources

The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells [PDF]

Blood, 1996
Fanconi anemia (FA) cells are hypersensitive to cytotoxicity, cell cycle arrest, and chromosomal aberrations induced by DNA cross-linking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2). Although MMC hypersensitivity is complemented in a subset of FA cells (complementation group C [FA-C]) by wild-type FAC cDNA, the cytoprotective mechanism
U K, Marathi, S R, Howell, R A, Ashmun, T P, Brent   +3 more
openaire   +2 more sources

DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. [PDF]

, 2014
BackgroundInduction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of
Cohen, Ezra EW, Farrow, Allan D, Finn, Stephen, Heitmann, Jana, Lingen, Mark W, O'Regan, Esther, Seiwert, Tanguy Y, Sprott, Kam, Stenson, Kerstin, Villegas-Bergazzi, Vivian, Vokes, Everett E, Wang, XiaoZhe, Weaver, David T, Weichselbaum, Ralph R   +13 more
core   +10 more sources

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Guc-Scekic, M, Joksic, G, Joksic, I, Leskovac, A, Ojani, M, Petrovic, S, Slijepcevic, P, Stankovic, A, Surralles, J, Trujillo, JP, Vujic, D, Zivkovic, M   +11 more
core   +3 more sources

Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms [PDF]

Journal of Biological Chemistry, 2012
The Fanconi anemia complementation group A (FANCA) gene is one of 15 disease-causing genes and has been found to be mutated in ∼60% of Fanconi anemia patients. Using purified protein, we report that human FANCA has intrinsic affinity for nucleic acids.
Fenghua, Yuan, Liangyue, Qian, Xinliang, Zhao, Jesse Y, Liu, Limin, Song, Gennaro, D'Urso, Chaitanya, Jain, Yanbin, Zhang   +7 more
openaire   +2 more sources

Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing [PDF]

, 2012
Fanconi anemia (FA) is a rare inherited disease characterized by developmental defects, short stature, bone marrow failure, and a high risk of malignancies. FA is heterogeneous: 15 genetic subtypes have been distinguished so far.
Ameziane, N., Floor, K., Gille, J.J.P., Joenje, H., Kerkhoven, L., Winter, J.P. de   +5 more
core   +3 more sources