Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers [PDF]
, 2015 PURPOSE: Fanconi anemia is an inherited disorder associated with a constitutional defect in the Fanconi anemia DNA repair machinery that is essential for resolution of DNA interstrand crosslinks.
Andreassen, Paul R. +11 more
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A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, Complementation group A, cells [PDF]
Nucleic Acids Research, 1993 A DNA binding protein with specificity for DNA containing interstrand cross-links induced by 4,5',8-trimethylpsoralen (TMP) plus long wavelength ultraviolet (UVA) light has been identified in normal human chromatin. Protein binding to DNA was determined using a gel mobility shift assay and an oligonucleotide containing a hot spot for formation of ...
B, Hang, A T, Yeung, M W, Lambert
openaire +2 more sources
Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]
, 2016 Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis +7 more
core +7 more sources
PLoS ONE, 2013 In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease that processes 5' flapped structures during maturation of lagging strand DNA synthesis, long patch base excision repair, and rescue of stalled replication forks. Here we report that fanconi anemia complementation group A protein (FANCA), a protein that recognizes
Liangyue Qian +4 more
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L’anémie de Fanconi : gènes et fonction(s) revisités [PDF]
, 2005 Des mutations dans les gènes FANC sont responsables de l’anémie de Fanconi (AF), une maladie génétique de phénotype complexe incluant une pancytopénie, des malformations congénitales et une prédisposition élevée au cancer.
Moustacchi, Ethel, Papadopoulo, Dora
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NOD2 controls expression of the Fanconi anemia complementation group M protein, FANCM.
, 2023 We provide evidence here from loss-of-function studies in mice and gain-of-function studies in human cells (1, 2) which demonstrate transcriptional activation of FANCM by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire +1 more source
Preventing hereditary cancers caused by opportunistic carcinogens [PDF]
, 2011 Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
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Gonadotropin-releasing hormone regulates expression of the DNA damage repair gene, Fanconi anemia A, in pituitary gonadotroph cells [PDF]
, 2004 Gonadal function is critically dependant on regulated secretion of the gonadotropin hormones from anterior pituitary gonadotroph cells. Gonadotropin biosynthesis and release is triggered by the binding of hypothalamic GnRH to GnRH receptor expressed on ...
Brown, Pamela +3 more
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A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. [PDF]
, 2013 When DNA replication is stalled at sites of DNA damage, a cascade of responses is activated in the cell to halt cell cycle progression and promote DNA repair. A pathway initiated by the kinase Ataxia teleangiectasia and Rad3 related (ATR) and its partner
Adachi, Jun +18 more
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