Results 11 to 20 of about 1,745 (114)

Comparison between [⁶⁸Ga]Ga-FAPI-46 and [¹⁸F]FDG PET/CT uptake in luminal-like vs. HER2-positive breast cancer. [PDF]

EJNMMI Res
Background Fibroblast activation protein (FAP)–targeted tracers have emerged as promising agents for breast cancer imaging, with recent studies demonstrating PET performance comparable to or surpassing, that of [18F]FDG.
Küper AT, Vaz SC, Pabst KM, Ciuciulkaite I, Mavroeidi IA, Hamacher R, Welt A, Hammersen N, Costa PF, Djaileb L, Seifert R, Umutlu L, Schuler M, Herrmann K, Fendler WP, Kümmel S, Kersting D.   +16 more
europepmc   +2 more sources

Swin UNETR-based prediction of [⁶⁸Ga]Ga-FAPI-46 PET/CT dose rate maps in cancer patients: quantitative comparison with [¹⁸F]FDG PET/CT. [PDF]

BMC Med Imaging
Background Fibroblast activation protein (FAP) is a promising theranostic target due to its high stroma expression in numerous malignancies. This study presents the first DL-based framework for predicting dose rate maps (DRMs) from [68Ga]Ga-FAPI-46 PET ...
Izadi-Yazdi S, Babapour-Mofrad F, Yazdani E, Karamzade-Ziarati N, Arabi H, Sadeghi M.   +5 more
europepmc   +2 more sources

[⁶⁸Ga]Ga-FAPI-46 PET enables non-invasive monitoring of hepatic fibrosis progression during TGF-β inhibition. [PDF]

Sci Rep
Hepatic fibrosis, a precursor to cirrhosis and hepatocellular carcinoma, affects millions worldwide but lacks effective therapies and depends on invasive liver biopsies for diagnosis, which hinder early intervention and monitoring.
Kim Y, Jeong M, Choi GE, Kwon H, Yoon HJ, Jeong YJ, Park JY, Kang DY, Jun S.   +8 more
europepmc   +2 more sources

Impact of FAPI-46/dual-tracer PET/CT imaging on radiotherapeutic management in esophageal cancer. [PDF]

Radiat Oncol
Background Fibroblast activation protein (FAP) is expressed in the tumor microenvironment (TME) of various cancers. In our analysis, we describe the impact of dual-tracer imaging with Gallium-68-radiolabeled inhibitors of FAP (FAPI-46-PET/CT) and ...
Wegen S, Claus K, Linde P, Rosenbrock J, Trommer M, Zander T, Tuchscherer A, Bruns C, Schlößer HA, Schröder W, Eich ML, Fischer T, Schomäcker K, Drzezga A, Kobe C, Roth KS, Weindler JJ.   +16 more
europepmc   +2 more sources

Production and Quality Control of [⁶⁸Ga]Ga-FAPI-46: Development of an Investigational Medicinal Product Dossier for a Bicentric Clinical Trial. [PDF]

Pharmaceuticals (Basel)
Background/Objectives: Fibroblast activation protein (FAP) is highly expressed in tumor stroma and selected inflammatory conditions, offering a promising target for molecular imaging. [68Ga]Ga-FAPI-46 is a DOTA-based FAP inhibitor with excellent tumor-to-
Cafaro A, Cuni C, Boschi S, Landi E, Foschi G, Monti M, Caroli P, Matteucci F, Masini C, Di Iorio V.   +9 more
europepmc   +2 more sources

Delayed ⁶⁸Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction. [PDF]

Int J Cardiol Heart Vasc
Purpose of the Report: Combined cardiac 68Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of ...
Kupusovic J, Kessler L, Kazek S, Chodyla MK, Umutlu L, Zarrad F, Nader M, Fendler WP, Varasteh Z, Hermann K, Dobrev D, Wakili R, Rassaf T, Siebermair J, Rischpler C.   +14 more
europepmc   +2 more sources

Revolutionizing cancer diagnosis and dose biodistribution: a meta-analysis of [68ga] FAPI- 46 vs. [18f] FDG imaging. [PDF]

Syst Rev
Background Advancements in novel peptides significantly affect cancer diagnosis by targeting cancer-specific markers, thereby improving imaging modalities, such as positron emission tomography combined with computed tomography (PET/CT) for more accurate ...
Abbasi S, Dehghani M, Khademi S, Irajirad R, Parizi ZP, Sahebi M, Sadeghi M, Montazerabadi A, Tavakoli M.   +8 more
europepmc   +2 more sources

Feasibility of ⁶⁸Ga-FAPI-46 PET for evaluating active fibrosis in aortic aneurysm. [PDF]

Sci Rep
Aortic aneurysm (AA) is a disease where aortic wall loses its elasticity, showing fibrosis. Fibroblast activation protein (FAP) expression can be evaluated using radiolabeled FAP-inhibitor (FAPI) PET in fibrosis.
Suh HY, Byun JW, Lee SP, Choi JW, Paeng JC.   +4 more
europepmc   +2 more sources

[68Ga]Ga-FAPI-46 PET/CT for Staging Suspected/Confirmed Lung Cancer: Results on the Surgical Cohort Within a Monocentric Prospective Trial. [PDF]

Pharmaceuticals (Basel)
Background/Objectives. To evaluate T&N-staging diagnostic performance of [68Ga]Ga-FAPI-46 PET/CT (FAPI) in a suspected/confirmed lung cancer surgical cohort.
Zanoni L, Fortunati E, Cuzzani G, Malizia C, Lodi F, Cabitza VS, Brusa I, Emiliani S, Assenza M, Antonacci F, Giunchi F, Degiovanni A, Ferrari M, Natali F, Galasso T, Bandelli GP, Civollani S, Candoli P, D'Errico A, Solli P, Fanti S, Nanni C.   +21 more
europepmc   +2 more sources

Development of a versatile [⁶⁸Ga]Ga-FAPI-46 automated synthesis suitable to multi-elutions of germanium-68/gallium-68 generators. [PDF]

Front Chem
Gallium-68-labeled FAPI-46 has recently been proposed as a novel positron emission tomography imaging probe to diagnose and monitor a wide variety of cancers.
Paty LP, Degueldre S, Provost C, Schmitt C, Trump L, Fouque J, Vriamont C, Valla F, Gendron T, Madar O.   +9 more
europepmc   +2 more sources