Results 31 to 40 of about 1,745 (114)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

Non-tumoral uptake of 68Ga-FAPI-04 PET: A retrospective study

Frontiers in Oncology, 2022
ObjectiveFibroblast activation protein (FAP)-targeting radiopharmaceutical based on the FAP-specific inhibitor (FAPI) is considered as a potential alternative agent to FDG for tumor-specific imaging. However, FAP is also expressed in normal adult tissues.
Na Qi, Hao Wang, Haiyan Wang, Shuhua Ren, Zhiwen You, Xing Chen, Yihui Guan, Fang Xie, Fengchun Hua, Jun Zhao   +9 more
doaj   +1 more source

Artificial Intelligence in Gastric Cancer: Diagnostic, Prognostic, and Predictive Developments, Evidence Maturity, and Translational Challenges

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) remains a major global health burden characterized by substantial heterogeneity in diagnosis, prognosis, and treatment response. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has been increasingly investigated for the analysis of endoscopic images, radiological scans, whole‐
Chong Chen, Weisong Xu, Tong Wu, Junpeng Zhao, Xuebing Xu, Mingbing Xiao, Kang Xu   +6 more
wiley   +1 more source

Contemporary Concise Review 2025: Interstitial Lung Disease

Respirology, Volume 31, Issue 10, Page 974-982, October 2026.
ABSTRACT Multidisciplinary discussion remains the cornerstone of ILD diagnosis and management, with recent advances further strengthening the integration of clinical, radiological, pathological, and molecular information. Updated ILD nomenclature and classification better align disease terminology with underlying morphology and pathobiology.
Tonia Magrì, Luca Richeldi
wiley   +1 more source

68Ga-FAPI PET/CT safely detects multifocal endometriosis: a case report

EJNMMI Reports
Purpose Endometriosis can be tough to diagnose accurately, especially when standard imaging misses hidden lesions. We explored whether 68Ga-FAPI-46 PET/CT, a new molecular imaging technique, could spot multifocal endometriosis that conventional methods ...
Ghasemali Divband, Arezoo Milani, Masoume Chehrara, Hossein Sharifi, Leila Hassanzadeh   +4 more
doaj   +1 more source

Head-to-head comparison of 18F-FAPI and 18F-FDG PET/CT in staging and therapeutic management of hepatocellular carcinoma

Cancer Imaging, 2023
Background Fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has limitations in staging hepatocellular carcinoma (HCC).
Jing Zhang, Shuqin Jiang, Mengsi Li, Haibao Xue, Xi Zhong, Shuyi Li, Hao Peng, Jiuceng Liang, Zhidong Liu, Songquan Rao, Haipeng Chen, Zewen Cao, Yuanfeng Gong, Guoshuo Chen, Rusen Zhang, Linqi Zhang   +15 more
doaj   +1 more source

Radiosynthesis and First Preclinical Evaluation of the Novel 11C-Labeled FAP Inhibitor 11C-FAPI: A Comparative Study of 11C-FAPIs and (68Ga) Ga-DOTA-FAPI-04 in a High–FAP-Expression Mouse Model

Frontiers in Chemistry, 2022
Purpose: 68Ga-labeled fibroblast activation protein inhibitors, such as [68Ga]Ga-DOTA-FAPI-04 and [68Ga]Ga-DOTA-FAPI-46, have been successfully applied in positron emission tomography imaging of various tumor types.
Cheng Wang, Zhoumi Hu, Fan Ding, Haitao Zhao, Fuqiang Du, Chun Lv, Lianghua Li, Gang Huang, Gang Huang, Jianjun Liu   +9 more
doaj   +1 more source

Dual‐view scout scans with deep learning for ultra‐low dose attenuation correction in PET

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Accurate attenuation correction (AC) is essential for quantitative positron emission tomography (PET). Conventional CT‐based AC provides reliable attenuation (μ‐) maps but adds radiation, introduces PET/CT misalignment artifacts, and is unavailable on stand‐alone PET systems.
Florence M. Muller, Margaret E. Daube‐Witherspoon, Michael J. Parma, Amy E. Perkins, Peter B. Noël, Christian Vanhove, Stefaan Vandenberghe, Joel S. Karp   +7 more
wiley   +1 more source