Results 51 to 60 of about 1,745 (114)

Head-to-head comparison of [18F]AlF-NOTA-FAPI-04 PET/CT and CE-MRI for diagnosing biliary tract cancer: a retrospective study

Frontiers in Medicine
PurposeTo evaluate the diagnostic performance of [18F]AlF-NOTA-FAPI-04 PET/CT in detecting primary and metastatic lesions in biliary tract cancer (BTC) and to compare it with contrast-enhanced (CE) MRI.Materials and methodsA total of 46 patients with ...
Yanyin Zhang, Xiang Peng, Chengzhi Jiang, Jian Yang, Kai Zheng, Hui Ye   +5 more
doaj   +1 more source

The FAP+ CAF subset in bladder cancer: A key driver of cancer cell stemness and a promising target for FAPI therapy

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Meiqian Li, Shikun Wang, Hua Xiao, Rong Hu, Yueyun Xie   +4 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, Volume 13, Issue 24, 27 April 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Clinical Advantages of Positron Emission Tomography/Computed Tomography and Positron Emission Tomography/Magnetic Resonance in Radiotherapy: A Narrative Review

iRADIOLOGY, Volume 4, Issue 2, Page 71-85, April 2026.
Review the clinical application of PET multimodal imaging and compare its clinical advantages. ABSTRACT Positron emission tomography (PET)–based multimodal imaging, including PET/computed tomography (PET/CT) and PET/magnetic resonance (PET/MR), plays an increasingly important role in precision radiotherapy by integrating metabolic and anatomical ...
Yingze Fu, Jyh‐Cheng Chen, Zhongying Ma, Junchi Ma, Jianfeng Qiu   +4 more
wiley   +1 more source

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

RMD Open
Objectives Activated synovial fibroblasts play a key role in rheumatoid arthritis (RA). Positron emission tomography-CT (PET-CT) using 68gallium-labelled fibroblast activation protein inhibitor (FAPI) allows the detection of FAP-expressing activated ...
Georg Schett, Andreas Ramming, Filippo Fagni, Christian Schmidkonz, Armin Atzinger, Arnd Kleyer, Torsten Kuwert, Axel J Hueber, Michael Beck, Koray Tascilar, Sara Bayat, Giulia Corte   +11 more
doaj   +1 more source

AUTOMATED SYNTHESIS AND IN VITRO STUDIES OF [68GA]GA-FAPI-46 IN HOSPITAL RADIOPHARMACY

Hematology, Transfusion and Cell Therapy
Introduction/Justification: Early evidence appointed fibroblast activation protein (FAP), a type II transmembrane serine protease, as highly expressed in the stroma of various tumor entities, designating FAP as the next target for cancer studies in ...
Leonardo Lima Fuscaldi, Paloma Caiado Lupinari, Karen Alessandra Kazumi Sato, Ana Claudia Camargo Miranda, Solange Nogueira Amorim, Taise Vitor, Jairo Wagner, Vasko Kramer, Lilian Yuri Itaya Yamaga, Luciana Malavolta, Marycel Figols de Barboza   +10 more
doaj   +1 more source

Feasibility of albumin binding modulation in FAP-targeting radiopharmaceuticals: insights from molecular docking and experimental analysis

EJNMMI Radiopharmacy and Chemistry
Background Understanding the interaction between radiopharmaceuticals and human serum albumin (HSA) is essential for optimizing pharmacokinetics and therapeutic efficacy.
Sudabeh Shokrollahi, Ahmad Amiri
doaj   +1 more source

Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy

Nuclear Medicine Review
This report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography.
Nasrin Raeisi, Amin Saber Tanha, Salman Soltani, Ali zare, Atena Aghaee   +4 more
doaj   +1 more source

In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics.
Circe D. van der Heide, Hanyue Ma, Mark W.H. Hoorens, Joana D. Campeiro, Debra C. Stuurman, Corrina M.A. de Ridder, Yann Seimbille, Simone U. Dalm   +7 more
doaj   +1 more source