Results 61 to 70 of about 1,745 (114)

Structure Optimization and Their Biodistribution in Tumor-bearing Mice on FAP and αⅤβ3 Dual Targeting Molecular Probes

Yuanzineng kexue jishu
Fibroblast activation protein (FAP) is a crucial biomarker for the activation of tumor associated fibroblasts, served as an excellent target for both the diagnosis and treatment of cancer.
WU Xiaoming1, 2, TIAN Guoxin3, WEN Xuejun2, 4, HE Tian1, 2, MA Fuqiu1, 3, XUE Yun1, 3
doaj   +1 more source

Positron Emission Tomography with Fibroblast Activation Protein-Targeted Radiopharmaceuticals in Primary Hepatic Tumors: A Systematic Review

Applied Sciences
Background: This systematic review was performed to investigate the potential diagnostic role of fibroblast activation protein (FAP)-targeted radiopharmaceuticals in hepatocarcinoma (HCC) and cholangiocarcinoma (CCA).
Lucia Semeraro, Viviana Frantellizzi, Luca Filippi, Barbara Palumbo, Giuseppe De Vincentis, Maria Silvia De Feo   +5 more
doaj   +1 more source

Radiolabelled FAPI Radiotracers in Oncology: A Comprehensive Review of Current Diagnostic and Emerging Therapeutic Applications

Pharmaceuticals
Background/Objectives: Fibroblast activation protein (FAP), which is abundantly expressed in cancer-associated fibroblasts (CAFs) across various epithelial malignancies, has emerged as a promising target for molecular imaging and radionuclide therapy ...
Jolanta Czuczejko, Bogdan Małkowski, Jarosław Nuszkiewicz, Iga Hołyńska-Iwan, Paweł Waśniowski, Katarzyna Mądra-Gackowska, Wiktor Dróżdż, Karolina Szewczyk-Golec   +7 more
doaj   +1 more source

Aged‐Related Fibroblast Activation Protein Expression in Skeletal Muscles Evaluated by PET Imaging

Journal of Cachexia, Sarcopenia and Muscle
Background Fibroblast activation protein (FAP) is prominently involved in the tumour microenvironment and tissue remodelling processes in most cancers, and its expression is also noted in normal skeletal muscle.
Minseok Suh, Joonhyung Gil, Yeon‐Koo Kang, Hongyoon Choi, Gi Jeong Cheon   +4 more
doaj   +1 more source

Fibroblast Activation Protein Inhibitor (FAPI) PET: A Scoping Review of Emerging Oncologic and Fibroinflammatory Applications

Diagnostics
This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines.
Emmanouil Panagiotidis, Filippos Koinis, Jules Zhang-Yin, George Angelidis, Varvara Valotassiou, Ioannis Tsougos, Athanasios Kotsakis, Panagiotis Georgoulias   +7 more
doaj   +1 more source

Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer

Scientific Reports
To explore the diagnostic performance of [99mTc]Tc-FAPI SPECT/CT for gastrointestinal cancer, compared to [18F]FDG PET/CT. In this analysis of a prospective trial, consecutively recruited patients from a single center with pathologically confirmed ...
Yu Zhang, Hong Chen, Dajia Lin, Zhiyi Lin, Jiyun Shi, Hannan Gao, Chenshen Huang, Fangqing Xue, Fan Wang, Wenxin Chen   +9 more
doaj   +1 more source

Increasing the activity output and optimization of automated radiosynthesis [68Ga]Ga-DOTATATE, [68Ga]Ga-Pentixafor, and [68Ga]Ga-FAPI-64 using two [68Ge]Ge/[68Ga]Ga iThemba generators in series

EJNMMI Radiopharmacy and Chemistry
Background The rapidly increasing clinical demand for 68Ga-labelled radiopharmaceuticals continues to challenge current production capacities, particularly in high-throughput nuclear medicine departments.
Ammar Alfteimi, Ulf Lützen, Alexander Helm, Michael Jüptner, Yi Zhao, Maaz Zuhayra   +5 more
doaj   +1 more source

Translational Theranostics in Glioblastoma: FAPI-46 as a Precision Medicine Tool. [PDF]

J Nucl Med
Jeanjean P, Swaidan A, Tse C, Kwock S, Fajnorova I, Dove R, Azrour IC, Taylor S, Comin-Anduix B, Nathanson DA, Carlucci G, Calais J, Czernin J, Besserer-Offroy É, Mona CE.   +14 more
europepmc   +1 more source

Kinetic modelling of [⁶⁸Ga]Ga-FAPI-46 PET in pancreaticobiliary lesions: distinguishing cancer from pancreatitis. [PDF]

Eur J Nucl Med Mol Imaging
Nilsson T, Rasinski P, Sparrelid E, Tzortzakakis A, Tran TA, Smedby Ö, Axelsson R, Lubberink M, Holstensson M.   +8 more
europepmc   +1 more source

Parametric mapping of dynamic ⁶⁸Ga FAPI-46-PET data of 42 patients with pancreatic lesions. [PDF]

Cancer Imaging
Spektor AM, von Goetze I, Buchholz HG, Heger U, Lang M, Liermann J, Knoll M, Herfarth K, Schreckenberger M, Debus J, Haberkorn U, Röhrich M.   +11 more
europepmc   +1 more source