Results 41 to 50 of about 47,001 (202)

Characterising fine‐scale habitat associations for range expanding species with limited data: a case study on the West Nile Virus vector, Culex modestus

Oikos, EarlyView.
The ecological and epidemiological consequences of species expanding into new areas are growing concomitantly with climate change. Those aiming to monitor species expanding in range must make optimal use of finite resources to deliver effective surveillance capable of detecting new incursions and range expansions.
Susanna Cant, Owen Jones, Maisie Vollans, Maximilian Ayling, Nyall Jamieson, Alexander G. C. Vaux, Jolyon M. Medlock, Thomas Ward, Julie Day, Robert S. Paton   +9 more
wiley   +1 more source

Immunotherapeutic and Targeted Approaches in Multiple Myeloma

ImmunoTargets and Therapy, 2020
Omar Nadeem, Yu-Tzu Tai, Kenneth C Anderson Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USACorrespondence: Omar NadeemDana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USATel +1 617-632 ...
Nadeem O, Tai YT, Anderson KC
doaj  

Respiratory profile of pediatric patients undergoing hematopoietic stem cell transplantation studied by oscillometry – A TRANSPIRE cohort

Pediatric Investigation, EarlyView.
These are results from a multi‐center collaboration between four large pediatric institutions, investigating baseline respiratory system function in a cohort of children undergoing hematopoietic stem cell transplantation. This manuscript proposes respiratory oscillometry as a novel way to prospectively follow lung function in these children.
Maureen B. Parenti, Julian Allen, Lisa R. Young, Heather Boas, Jason Freedman, Christopher Towe, Jane Koo, Kasiani Myers, Jason C. Woods, Adam Lane, Jonathan Gaffin, Wai Wong, Leslie Lehmann, Fernando Urrego, Gabriel Salinas Cisneros, Matthew F. Abts, K. Scott Baker, Manuel Silva‐Carmona, Erin Doherty, Paul D. Robinson, Margaret MacMillan, Stella M. Davies, Samuel B. Goldfarb   +22 more
wiley   +1 more source

Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration

Cells, 2020
Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases.
Carolina Duarte, Juliet Akkaoui, Chiaki Yamada, Anny Ho, Cungui Mao, Alexandru Movila   +5 more
doaj   +1 more source

Insulin‐Like Growth Factor Axis and Survival in Metastatic Hormone‐Sensitive Prostate Cancer: Post‐Hoc Analysis From the ENZAMET Phase 3 Trial

The Prostate, EarlyView.
ABSTRACT Background A higher ratio of IGF‐1:IGF binding protein 1 (IGFBP1) was associated with improved prognosis in the CHAARTED trial of docetaxel in participants with metastatic hormone‐sensitive prostate cancer (mHSPC). The ENZAMET trial demonstrated the survival benefit of adding enzalutamide to androgen deprivation therapy (ADT) in mHSPC, and ...
Michael A. Cilento, Hui‐Ming Lin, Nicole Yeung, Rachel M.N. Kim, Neil Portman, Martin R. Stockler, Andrew J. Martin, Vinod Subhash, Sonia Yip, Lisa M. Butler, Ian C. Marschner, Peter J. Meikle, Arun A. Azad, Ian D. Davis, Lisa G. Horvath, Christopher J. Sweeney   +15 more
wiley   +1 more source

Evaluation of Time to Metastasis After Prostatectomy as a Prognostic Factor in Patients With Metachronous mHSPC: A Secondary Analysis of the SWOG‐1216 Phase 3 Trial

The Prostate, EarlyView.
ABSTRACT Background The prognostic significance of time to metastasis (TTM) following radical prostatectomy in patients with metachronous metastatic hormone‐sensitive prostate cancer (mHSPC) remains uncertain. We performed a secondary analysis of patient‐level data from the phase 3 SWOG 1216 randomized clinical trial to evaluate whether TTM is ...
Nicolas Sayegh, Yeonjung Jo, Umang Swami, Varun Nandakumar, Georges Gebrael, Zeynep Irem Ozay, Haoran Li, Krishnam Goel, Benjamin L. Maughan, Melissa Plets, Maha H. A. Hussain, Tanya B. Dorff, Primo N. Lara Jr., Amir Goldkorn, Seth P. Lerner, Neeraj Agarwal   +15 more
wiley   +1 more source

Unlocking the therapeutic potential of selective CDK7 and BRD4 Inhibition against multiple myeloma cell growth

Haematologica
Multiple myeloma (MM) is a plasma cell malignancy considered incurable despite the recent therapeutic advances. Effective targeted therapies are therefore needed.
Yao Yao, Shuhui Deng, Jessica Fong Ng, Mei Yuan, Chandraditya Chakraborty, Vera JoyWeiler, Nikhil Munshi, Mariateresa Fulciniti   +7 more
doaj   +1 more source

Tumor SQSTM1 (p62) expression and T cells in colorectal cancer

OncoImmunology, 2017
Evidence suggests that activation of autophagy in neoplastic cells potentiates antitumor immunity through cross-presentation of tumor-associated antigens to T cells and release of immune mediators.
Keisuke Kosumi, Yohei Masugi, Juhong Yang, Zhi Rong Qian, Sun A. Kim, Wanwan Li, Yan Shi, Annacarolina da Silva, Tsuyoshi Hamada, Li Liu, Mancang Gu, Tyler S. Twombly, Yin Cao, David A. Barbie, Katsuhiko Nosho, Hideo Baba, Wendy S. Garrett, Jeffery A. Meyerhardt, Edward L. Giovannucci, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino, Reiko Nishihara   +22 more
doaj   +1 more source

Characteristics and early outcomes of cervical cancer patients at Butaro District Hospital, Rwanda: a retrospective review

The Lancet Global Health, 2017
Background: Cancer treatment facilities are scarce in rural areas of low-income and middle-income countries, where the highest burden of cervical cancer exists.
Sonya Davey, MPhil, Egide Mpanumusingo, MD, Alex Fehr, MPH, John Butonzi, MD, Cyprien Shyireambere, MD, Vedaste Hategekimana, RN, Jean Bosco Bigirimana, RN, Ryan Borg, MPH, Regis Uwizeye, Neo Tapela, MD, Tom Randall, MD, Lawrence Shulman, MD, Paul Park, MD, Tharcisse Mpunga, MD   +13 more
doaj   +1 more source

Income Mobility, Automation, and Occupational Licensing

Southern Economic Journal, EarlyView.
ABSTRACT Technological change has long been tied with distributional concerns due to displacement against certain skills on labor markets. Short‐run dislocations could create scarring in the long run. For example, shifts against less skilled workers with children could limit their ability to improve the inter‐generational income mobility of their ...
Vincent Geloso, Alicia Plemmons, Pradyot Sharma   +2 more
wiley   +1 more source