Results 51 to 60 of about 47,001 (202)
Unravelling variants in Farber disease: diagnostic and prenatal challenges in atypical presentations
Egyptian Journal of Medical Human GeneticsFarber disease (FD; OMIM #228000), also known as Farber's lipogranulomatosis, is a rare lysosomal storage disease caused by acid ceramidase deficiency. Clinically, FD is typically identified by a triad of symptoms: subcutaneous nodules, joint pain, and ...
Pritti Kumari +4 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky +28 more
wiley +1 more source
New Microbes and New InfectionsBackground: Immunocompromised individuals have a limited humoral immune response to SARS-CoV-2 vaccination and are at higher risk of severe COVID-19.
Isabel H. Gonzalez-Bocco +20 more
doaj +1 more source
Long‐term oncological outcomes from a prospective cohort of patients with localised prostate cancer
BJU International, EarlyView.Objectives To report long‐term oncological outcomes for men with clinically localised prostate cancer (PCa) treated with contemporary modalities in a population‐based United States cohort. Patients and Methods The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study prospectively enrolled men with clinically localised PCa from ...
Avi S. Baskin +17 more
wiley +1 more source
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
eLife, 2017 Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical responses in lung and other cancers, but some patients fail to respond and in those that do resistance inevitably occurs ...
Elsa B Krall +21 more
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Nonprofit Organizations as Platforms: How Local Embeddedness Shapes Value Creation
Creativity and Innovation Management, EarlyView.ABSTRACT Platforms have a business model that, through large‐scale network effects, orchestrates available resources by facilitating interactions between two or more distinct user groups. Although most research focuses on digital, for‐profit platforms, nonprofit organizations offer a compelling alternative arena for studying digital and non‐digital ...
Silvia Gadola +2 more
wiley +1 more source
Genetic Predictors of Mortality in Patients with Multiple Myeloma
The Application of Clinical Genetics, 2021 Hamza Hassan,1 Raphael Szalat1,2 1Department of Hematology and Medical Oncology, Boston University Medical Center, Boston, MA, USA; 2Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USACorrespondence: Raphael ...
Hassan H, Szalat R
doaj
The Economic History Review, EarlyView.Abstract One of the most contentious issues in the study of the Atlantic slave trade is the profitability of the trade. In this paper, we contribute by pooling all available data on transatlantic slave ship voyage accounts into a joint dataset. This dataset includes data from a period of 100 years (1730–1830) and from five nations (Denmark, France ...
Klas Rönnbäck +4 more
wiley +1 more source
Novel manifestations of Farber disease mimicking neuronopathic Gaucher disease. [PDF]
BMJ Case Rep, 2021 Mhatre S +3 more
europepmc +1 more source