Results 71 to 80 of about 47,001 (202)
Personalized medicine in breast cancer: pharmacogenomics approaches
Pharmacogenomics and Personalized Medicine, 2019 Shabnam Jeibouei,1 Mohammad Esmael Akbari,2 Alireza Kalbasi,3 Amir Reza Aref,4,5 Mohammad Ajoudanian,6 Alireza Rezvani,7 Hakimeh Zali81Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical ...
Jeibouei S +6 more
doaj
From bench to patient: model systems in drug discovery
Disease Models & Mechanisms, 2015 Model systems, including laboratory animals, microorganisms, and cell- and tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease.
Matthew D. Breyer +2 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source
Allogeneic hematopoietic cell transplantation in Farber disease
Journal of Inherited Metabolic Disease, 2018 AbstractBackgroundFarber disease (FD) is a rare, lysosomal storage disorder caused by deficient acid ceramidase activity. FD has long been considered a fatal disorder with death in the first three decades of life resulting either from respiratory insufficiency as a consequence of airway involvement or from progressive neurodegeneration because of ...
Ehlert, Karoline +9 more
openaire +4 more sources
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo +11 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 11, Page 2713-2725, November 2026.ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali +8 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 11, Page 2827-2835, November 2026.ABSTRACT Posttransplant cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD) improves outcomes in recipients of HLA mismatched unrelated donor (MMUD) allogeneic hematopoietic cell transplantation (allo HCT). Outcomes of MMUD HCT using PTCy in patients requiring reduced intensity or non‐myeloablative conditioning (RIC/NMA) are not well ...
Brian C. Shaffer +38 more
wiley +1 more source
Adaptive Immunity in Marsupials
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol +2 more
wiley +1 more source
Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.Abstract A domestic shorthair cat was presented with lethargy and inappetence. Abdominal ultrasound revealed a large jejunal mural mass with diffuse wall thickening without loss of wall layering, severe jejunal lymphadenopathy, and moderate peritoneal effusion.
Riley Aronson +4 more
wiley +1 more source