Results 81 to 90 of about 47,001 (202)
Effects of Atmospheric CO2 Levels on the Susceptibility of Maize to Diverse Pathogens
Plant, Cell &Environment, Volume 49, Issue 11, Page 8828-8850, November 2026.ABSTRACT
Rising atmospheric CO2 has significant implications for crop productivity and food security. Based on studies in C3 plants, elevated CO2 (eCO2) can shape plant‐pathogen interactions, although the outcomes are often variable. The question of how eCO2 influences immunity and disease development in C4 plants, such as the globally important cereal Ekkachai Khwanbua, Yunhui Qi, John Ssengo, Peng Liu, Michelle A. Graham, Steven A. Whitham +5 morewiley +1 more sourceThe need for dried plasma—Still a national issue: Where are we and recommendations
Transfusion, EarlyView.Anthony E. Pusateri, Shibani Pati, Toby A. Silverman, Roman Dudaryk, Joseph F. Rappold, Lisa Buckley, Andrew P. Cap, Jose A. Cancelas, Laurence M. Corash, G. Michael Fitzpatrick, Michael Ganio, Adam Gerber, Richard Gonzales, Jennifer M. Gurney, Ernest E. Moore, Hunter B. Moore, Vijayan Nair, Michael Policastro, Travis M. Polk, Jeffrey W. Shupp, Jason L. Sperry, Ralph R. Vassallo, Therese A. West, John B. Holcomb, Lester Martinez‐Lopez +24 morewiley +1 more sourceEngineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma
Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla +7 morewiley +1 more sourceQuantitation of Cirtuvivint (SM08502) in Human Plasma by LC–MS/MS
Biomedical Chromatography, Volume 40, Issue 10, October 2026.ABSTRACT
CDC‐like kinases (CLK) and dual‐specificity tyrosine‐regulated kinases (DYRK) are protein kinases involved in various cellular functions, mRNA splicing, and DNA damage repair. CLK/DYRK kinases have been implicated in many disorders such as diabetes, neurodegenerative diseases, and cancer.Julianne L. Holleran, Joshua J. Deppas, Ye Feng, Michael J. Hochman, Evan C. Chen, Maximilian Stahl, Steven D. Gore, Timothy W. Synold, Jan H. Beumer, Raman Venkataramanan, Robert A. Parise +10 morewiley +1 more sourceTreatment Patterns and Clinical Outcomes Among Chinese Patients With Newly Diagnosed Multiple Myeloma: A Multicenter Retrospective Study (CHAMP‐MM)
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT
The therapeutic landscape for newly diagnosed multiple myeloma (NDMM) in China has evolved significantly with wider access to novel agents, including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and CD38 monoclonal antibodies.Jian Cui, Xiaoyan Qu, Chunrui Li, Fei Li, Liye Zhong, Xiaohong Fu, Gang Liu, Lugui Qiu, Gang An +8 morewiley +1 more sourceAssociation of Travel Time With Definitive Prostate Cancer Treatment: A United States Registry Cohort Study
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Purpose
Prostate cancer (PCa) mortality disparities are partly driven by unequal access to care. Transportation barriers may limit access to definitive treatment. We studied how driving travel time affects receipt of definitive PCa treatment. Materials and Methods
We conducted a cohort study of men with non‐metastatic PCa (2000–2015; follow‐up Filippo Dagnino, Stephan Korn, Danesha Daniels, Zhiyu Qian, Daniel Stelzl, Hanna Zurl, Klara Pohl, Mei‐Chin Hsieh, Brenda Y. Hernandez, Andrea Piccolini, Giovanni Lughezzani, Nicolò M. Buffi, Stuart R. Lipsitz, Amanda Reich, Joel S. Weissman, Alexander P. Cole, Quoc‐Dien Trinh, Hari S. Iyer +17 morewiley +1 more sourcePhase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc‐fusion protein SL‐172154 (SIRPα‐Fc‐CD40L) in patients with higher‐risk myelodysplastic syndrome or acute myeloid leukemia
Cancer, Volume 132, Issue 19, 1 October 2026.Abstract Background
This clinical trial sought to determine whether SL‐172154 could be combined safely and improve the efficacy of azacitidine (AZA) in patients with higher‐risk myelodysplastic syndrome (HR‐MDS) or acute myeloid leukemia (AML). Methods
Dose escalation: doses of 1, 3, and 6 mg/kg SL‐172154 was evaluated as monotherapy or in combination ...Naval G. Daver, Amer M. Zeidan, Anthony S. Stein, Joshua F. Zeidner, Keri Maher, Emily Curran, Dale Bixby, Wanxing Chai‐Ho, Maximilian Stahl, Karen W. L. Yee, Don Stevens, Sawa Ito, Jana Reynolds, Patrick Medd, Emma Searle, Andrew Sochacki, Mary Lynn Savoie, Steven Green, Kazunobu Kato, Robert Hernandez, Simon Metenou, Bo Ma, Lini Pandite, Taylor H. Schreiber, David A. Sallman +24 morewiley +1 more sourceBortezomib in the management of multiple myeloma
Cancer Management and Research, 2009 Jacob P Laubach, Constantine S Mitsiades, Teru Hideshima, Robert Schlossman, Dharminder Chauhan, Nikhil Munshi, Irene Ghobrial, Nicole Carreau, Kenneth C Anderson, Paul G RichardsonDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston ...Jacob P Laubach, Constantine S Mitsiades, Teru Hideshima, et al +3 moredoaj A platform of serially transplantable AML PDX models covering subgroups for which no cell lines exist
HemaSphere, Volume 10, Issue 10, October 2026.Abstract
Acute myeloid leukemia (AML) is a highly aggressive malignancy with poor prognosis, underlining the need for suitable model systems to develop novel treatments. To complement the few existing AML cell lines and restricted primografts, we transplanted more than 100 primary AML samples into immunocompromised mice and generated 23 exceptionally ...Binje Vick, Vindi Jurinovic, Kristina Kuhbandner, Lena Lagally, Lisa Latzko, Chiara Arnreich, Gerulf Hänel, Amelie Muth, Maximilian Schönung, Arnold Kloos, Maja Rothenberg‐Thurley, Annika M. Dufour, Stephanie Schneider, Lesca M. Holdt, Liliana Mura, Fabian Klein, Annette Frank, Dhruv Mehra, Annika Fröhlich, Johannes W. Bagnoli, Maya C. André, Claudia D. Baldus, Martin Carroll, Christine Dierks, Martin Ebinger, Katharina S. Götze, Pablo Menéndez, Christian Récher, Ambrine Sahal, Jean‐Emmanuel Sarry, Christian Thiede, Talía Velasco‐Hernández, Xiaoyan Wei, Jan H. Klusmann, Wolfgang Enard, Michael von Bergwelt‐Baildon, Wolfgang Hiddemann, Klaus H. Metzeler, Philipp A. Greif, Michael Heuser, Daniel B. Lipka, Marion Subklewe, Sebastian Vosberg, Tobias Herold, Karsten Spiekermann, Irmela Jeremias +45 morewiley +1 more source