Results 81 to 90 of about 47,001 (202)

Effects of Atmospheric CO2 Levels on the Susceptibility of Maize to Diverse Pathogens

open access: yesPlant, Cell &Environment, Volume 49, Issue 11, Page 8828-8850, November 2026.
ABSTRACT Rising atmospheric CO2 has significant implications for crop productivity and food security. Based on studies in C3 plants, elevated CO2 (eCO2) can shape plant‐pathogen interactions, although the outcomes are often variable. The question of how eCO2 influences immunity and disease development in C4 plants, such as the globally important cereal
Ekkachai Khwanbua   +5 more
wiley   +1 more source

The need for dried plasma—Still a national issue: Where are we and recommendations

open access: yes
Transfusion, EarlyView.
Anthony E. Pusateri   +24 more
wiley   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett   +7 more
wiley   +1 more source

Quantitation of Cirtuvivint (SM08502) in Human Plasma by LC–MS/MS

open access: yesBiomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT CDC‐like kinases (CLK) and dual‐specificity tyrosine‐regulated kinases (DYRK) are protein kinases involved in various cellular functions, mRNA splicing, and DNA damage repair. CLK/DYRK kinases have been implicated in many disorders such as diabetes, neurodegenerative diseases, and cancer.
Julianne L. Holleran   +10 more
wiley   +1 more source

Treatment Patterns and Clinical Outcomes Among Chinese Patients With Newly Diagnosed Multiple Myeloma: A Multicenter Retrospective Study (CHAMP‐MM)

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT The therapeutic landscape for newly diagnosed multiple myeloma (NDMM) in China has evolved significantly with wider access to novel agents, including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and CD38 monoclonal antibodies.
Jian Cui   +8 more
wiley   +1 more source

Association of Travel Time With Definitive Prostate Cancer Treatment: A United States Registry Cohort Study

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Purpose Prostate cancer (PCa) mortality disparities are partly driven by unequal access to care. Transportation barriers may limit access to definitive treatment. We studied how driving travel time affects receipt of definitive PCa treatment. Materials and Methods We conducted a cohort study of men with non‐metastatic PCa (2000–2015; follow‐up
Filippo Dagnino   +17 more
wiley   +1 more source

Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc‐fusion protein SL‐172154 (SIRPα‐Fc‐CD40L) in patients with higher‐risk myelodysplastic syndrome or acute myeloid leukemia

open access: yesCancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background This clinical trial sought to determine whether SL‐172154 could be combined safely and improve the efficacy of azacitidine (AZA) in patients with higher‐risk myelodysplastic syndrome (HR‐MDS) or acute myeloid leukemia (AML). Methods Dose escalation: doses of 1, 3, and 6 mg/kg SL‐172154 was evaluated as monotherapy or in combination ...
Naval G. Daver   +24 more
wiley   +1 more source

Bortezomib in the management of multiple myeloma

open access: yesCancer Management and Research, 2009
Jacob P Laubach, Constantine S Mitsiades, Teru Hideshima, Robert Schlossman, Dharminder Chauhan, Nikhil Munshi, Irene Ghobrial, Nicole Carreau, Kenneth C Anderson, Paul G RichardsonDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston ...
Jacob P Laubach   +3 more
doaj  

A platform of serially transplantable AML PDX models covering subgroups for which no cell lines exist

open access: yesHemaSphere, Volume 10, Issue 10, October 2026.
Abstract Acute myeloid leukemia (AML) is a highly aggressive malignancy with poor prognosis, underlining the need for suitable model systems to develop novel treatments. To complement the few existing AML cell lines and restricted primografts, we transplanted more than 100 primary AML samples into immunocompromised mice and generated 23 exceptionally ...
Binje Vick   +45 more
wiley   +1 more source

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