Results 11 to 20 of about 5,098 (167)

Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development

Advanced Science
Oligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms ...
Wenwen Wang, Yanyan Wang, Libo Su, Mengtian Zhang, Tianyu Zhang, Jinyue Zhao, Hongyan Ma, Dongming Zhang, Fen Ji, Ryan Dingli Jiao, Hong Li, Yuming Xu, Lei Chen, Jianwei Jiao   +13 more
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Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase [PDF]

Biochemistry, 2012
Farnesylation is an important post-translational modification essential for the proper localization and function of many proteins. Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by protein farnesyltransferase (FTase).
Thangaiah, Subramanian, June E, Pais, Suxia, Liu, Jerry M, Troutman, Yuta, Suzuki, Karunai, Leela Subramanian, Carol A, Fierke, Douglas A, Andres, H Peter, Spielmann   +8 more
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Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase [PDF]

Bioorganic & Medicinal Chemistry Letters, 2016
Attempts to identify the prenyl-proteome of cells or changes in prenylation following drug treatment have used 'clickable' alkyne-modified analogs of the lipid substrates farnesyl- and geranylgeranyl-diphosphate (FPP and GGPP). We characterized the reactivity of four alkyne-containing analogs of FPP with purified protein farnesyltransferase and a small
Jennings, Benjamin C., Danowitz, Amy M., Wang, Yen-Chih, Gibbs, Richard A., Distefano, Mark D., Fierke, Carol A.   +5 more
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Farnesyl‐diphosphate farnesyltransferase 1 regulates hepatitis C virus propagation

FEBS Letters, 2014
To identify the novel genes involved in lipid metabolism and lipid droplet formation that may play important roles in Hepatitis C virus (HCV) propagation, we have screened the small interfering RNA library using cell culture derived HCV (HCVcc)‐infected cells.
Park, Eun-Mee, Nguyen, Lam N., Lim, Yun-Sook, Hwang, Soon B.   +3 more
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The mechanism and clinical application of farnesyl diphosphate farnesyltransferase 1 in cancer metabolism

Biochemical and Biophysical Research Communications
Cancer poses a significant risk to human well-being. Among the crucial characteristics of cancer is metabolic reprogramming. To meet the relentless metabolic needs, cancer cells enhance cholesterol metabolism within the adverse tumor microenvironment.
Nanxin Li, Guojuan Wang, Min Guo, Naicheng Zhu, Wenyan Yu   +4 more
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Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Communications Biology, 2023
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun, Diming Liu, Weiwei Cui, Huimin Cheng, Lixia Huang, Ruihao Zhang, Junlian Gu, Shuo Liu, Xiao Zhuang, Yi Lu, Bo Chu, Jian Li   +11 more
doaj   +2 more sources

RETRACTED ARTICLE: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Nature Communications, 2020
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear.
Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao   +15 more
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Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1

Frontiers in Pharmacology
IntroductionValproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However,
Shuxian Zhang, Jiazhuo Liu, Yisong Yang, Ran Tao, Xin Ren, Xingzhi Zhou, Shuangping Liu   +6 more
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Follicle stimulating hormone stimulates farnesyl-diphosphate farnesyltransferase 1 expression through LSD1Ser54p in chicken ovarian granulosa cells. [PDF]

Poult Sci
Zhang Y, Zhang M, Liu Q, Jiang Y.
europepmc   +2 more sources

Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Extract in BT-549 Triple-Negative Breast Cancer Cells. [PDF]

Food Sci Nutr
Transcriptomic profiling showed that carotenoid‐rich lipophilic sea buckthorn extract (LSBE) significantly altered genes controlling cholesterol metabolism, mTORC1 signaling, oxidative stress, and ferroptosis in BT‐549 TNBC cells. These findings generate mechanistic hypotheses for LSBE as a potential complementary approach in TNBC therapy, pending ...
Visan S, Balacescu L, Drigla F, Balacescu O, Pintea A.   +4 more
europepmc   +2 more sources