ISOPRENOID ANALOGS AS CHEMICAL GENETIC TOOLS TO PROVIDE INSIGHTS INTO FARNESYL TRANSFERASE TARGET SELECTION AND CELLULAR ACTIVITY [PDF]
, 2006 Protein farnesylation is an essential post-translational modification required for the function of numerous cellular proteins including the oncoprotein Ras. The farnesyl transferase (FTase) catalyzed reaction is unique because farnesyl diphosphate (FPP),
Troutman, Jerry
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Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model [PDF]
, 2013 Human Polynucleotide Phosphorylase (hPNPaseold-35 or PNPT1) is an evolutionarily conserved 3′→5′ exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and aging ...
Bacolod, Manny D. +4 more
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Protein farnesyltransferase and protein prenylation in Plasmodium falciparum [PDF]
, 2002 Comparison of the malaria parasite and mammalian protein prenyltransferases and their cellular substrates is important for establishing this enzyme as a target for developing antimalarial agents.
Allen, Charles M. +6 more
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Engineering Protein Farnesyltransferase for Enzymatic Protein Labeling Applications
Bioconjugate chemistry, 2014 Creating covalent protein conjugates is an active area of research due to the wide range of uses for protein conjugates spanning everything from biological studies to protein therapeutics.
Jonathan K. Dozier +5 more
semanticscholar +1 more source
Navigating Metabolic Challenges in Ovarian Cancer: Insights and Innovations in Drug Repurposing
Cancer Medicine, Volume 14, Issue 4, February 2025.ABSTRACT Background Ovarian cancer (OC) is the most lethal gynecological malignancy and a major global health concern, often diagnosed at advanced stages with poor survival rates. Despite advancements in treatment, resistance to standard chemotherapy remains a critical challenge with limited treatment options available.
Sara Mikhael, Georges Daoud
wiley +1 more source
Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]
, 2018 Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia +2 more
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Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele
Brain Pathology, Volume 34, Issue 1, January 2024.Genetic variation in the APOE genotype form the basis of the clinical phenotype. Abstract The apolipoprotein E ɛ4 allele (APOE4) is universally acknowledged as the most potent genetic risk factor for Alzheimer's disease (AD). APOE4 promotes the initiation and progression of AD. Although the underlying mechanisms are unclearly understood, differences in
Xiao‐Yu Ji +7 more
wiley +1 more source
Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells [PDF]
, 2001 Proteins belonging to the ras superfamily are involved in cell proliferation of normal and neoplastic tissues. To be biologically active, they require post-translational isoprenylation by farnesyl-transferase and geranylgeranyl-transferase.
Boggi, U +8 more
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Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation [PDF]
, 2013 Many proteins require prenylation in order to be biologically functional. Some such proteins include the small Ras and Rho GTPase superfamilies, nuclear lamins A and B, and the kinesin motor proteins CENP-E and F.
Temple, Kayla Jo
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Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis [PDF]
, 2015 The entomopathogenic nematode Heterorhabditis bacteriophora forms a specific mutualistic association with its bacterial partner Photorhabdus temperata.
Abebe-Akele, Feseha +9 more
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