Results 141 to 150 of about 9,807 (200)

A novel approach towards the synthesis of pyrophosphate analogues of farnesyl pyrophosphate

open access: yesRecueil des Travaux Chimiques des Pays-Bas, 1994
AbstractThe synthesis of two new analogues (i.e. 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.
Valentijn, A.R.P.M.   +4 more
openaire   +3 more sources

Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

Bioorganic and Medicinal Chemistry, 1998
Several phosphonate and bisphosphonate analogues of farnesyl pyrophosphate have been prepared for an examination of their ability to inhibit farnesyl protein transferase (FPTase). A Horner-Wadsworth-Emmons condensation of farnesal or geranial with tetraethyl methylenediphosphonate gave the desired vinyl phosphonates, while alkylation of the dimethyl ...
Sarah A Holstein   +2 more
exaly   +3 more sources

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