Results 161 to 170 of about 9,807 (200)

Brain Isoprenoids Farnesyl Pyrophosphate and Geranylgeranyl Pyrophosphate are Increased in Aged Mice

Molecular Neurobiology, 2012
The mevalonate/isoprenoids/cholesterol pathway has a fundamental role in the brain. Increasing age could be associated with specific changes in mevalonate downstream products. Other than age differences in brain cholesterol and dolichol levels, there has been little if any evidence on the short-chain isoprenoids farnesylpyrophosphate (FPP) and ...
Gero P, Hooff, W Gibson, Wood, Ji-Hyun, Kim, Urule, Igbavboa, Wei-Yi, Ong, Walter E, Muller, Gunter P, Eckert   +6 more
openaire   +2 more sources

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

Bioorganic & Medicinal Chemistry Letters, 2010
A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented.
Joris W, De Schutter, Serge, Zaretsky, Sarah, Welbourn, Arnim, Pause, Youla S, Tsantrizos   +4 more
openaire   +2 more sources

Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate

Acta Crystallographica Section F, Structural Biology Communications, 2014
Nitrogen-containing bisphosphonates (N-BPs), such as risedronate and zoledronate, are currently used as a clinical drug for bone-resorption diseases and are potent inhibitors of farnesyl pyrophosphate synthase (FPPS).
Takeshi Yokoyama, Andreas Ostermann, Mineyuki Mizuguchi   +2 more
exaly   +2 more sources

The formation of cyclic sesquiterpenes from farnesyl pyrophosphate by prenyltransferase

Archives of Biochemistry and Biophysics, 1981
Abstract Prenyltransferase, which normally catalyzes the 1′-4 condensation which is the basic polymerization of polyterpenoid and cholesterol biosynthesis, also mediates a pyrophosphate-dependent solvolysis of its substrates. We had previously shown that this was an aberration of the normal reaction and that dimethylallyl alcohol and geraniol were ...
A, Saito, H C, Rilling
openaire   +2 more sources

Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates

Biochemical and Biophysical Research Communications, 1999
Bisphosphonates (Bps), inhibitors of osteoclastic bone resorption, are used in the treatment of skeletal disorders. Recent evidence indicated that farnesyl pyrophosphate (FPP) synthase and/or isopentenyl pyrophosphate (IPP) isomerase is the intracellular target(s) of bisphosphonate action. To examine which enzyme is specifically affected, we determined
Beek, E. van, Pieterman, E., Cohen, L., Löwik, C., Papapoulos, S.   +4 more
openaire   +3 more sources

Aristolochene biosynthesis and enzymatic cyclization of farnesyl pyrophosphate

Journal of the American Chemical Society, 1989
Proposition d'un schema reactionnel concernant la biosynthese d'un sesquiterpene, en l'occurrence l'aristolochene, chez Aspergillus terrus.
David E. Cane, P. C. Prabhakaran, E. J. Salaski, Paul H. M. Harrison, Hiroshi Noguchi, Bernard J. Rawlings   +5 more
openaire   +1 more source

Synthesis of pyrophosphonic acid analogues of farnesyl pyrophosphate

Tetrahedron, 1995
The synthesis of four new analogues (i.e. 3-6) of farnesyl pyrophosphate (FPP), which may function as inhibitor of squalene synthase, is described. Compounds 3 and 4 were readily accessible by reaction of farnesal with diethyl phosphite or dimethyl lithiomethylphosphonate, respectively, followed by condensation of the resulting alcohols with diethyl ...
Valentijn, A.R.P.M., Berg, O. van den, Marel, G.A. van der, Cohen, L.H., Boom, J.H. van   +4 more
openaire   +2 more sources

Mechanism of the biosynthesis of squalene from farnesyl pyrophosphate

Tetrahedron, 1987
Abstract The biosynthesis of squalene (1) from farnesyl pyrophosphate (2) has been studied by carrying out calculations for models. The suggested mechanism involves initial allylic attack on 2 by the enzyme, probably by the trapping of farnesyl cation, followed by S N 2' reaction with a second molecule of 2 to form a π complex which is deprotonated ...
Michael J.S. Dewar, James M. Ruiz
openaire   +1 more source

Enzymatic synthesis of new farnesyl pyrophosphate homologues

Journal of the Chemical Society, Chemical Communications, 1972
3-Ethylbut-3-enyl pyrophosphate acts as a substrate for farnesyl pyrophosphate synthetase in place of isopentenyl pyrophosphate, to give farnesyl pyrophosphate homologues.
Kyozo Ogura, Tanetoshi Koyama, Shuichi Seto   +2 more
openaire   +1 more source

Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

Chemical Communications, 2010
The mevalonate pathway is an important drug target for the treatment of cancer and cardiovascular disease. We synthesized and studied a new type of nitrogen-containing bisphosphonate analogs and developed a sensitive end point assay method for enzyme FPPS, which was used for inhibitor screening.
Jinbo, Gao, Xiusheng, Chu, Yongge, Qiu, Long, Wu, Yuqin, Qiao, Jiasheng, Wu, Ding, Li   +6 more
openaire   +2 more sources