Results 171 to 180 of about 9,807 (200)

Investigation of the Catalytic Mechanism of Farnesyl Pyrophosphate Synthase by Computer Simulation

The Journal of Physical Chemistry B, 2006
Farnesyl pyrophosphate synthase (FPPS) catalyses the formation of a key cellular intermediate in isoprenoid metabolic pathways, farnesyl pyrophosphate, by the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP).
Verónica Muriel, Sanchez, Alejandro, Crespo, J Silvio, Gutkind, Adrián Gustavo, Turjanski   +3 more
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ChemInform Abstract: THE ENZYMIC CONVERSION OF FARNESYL TO NEROLIDYL PYROPHOSPHATE: ROLE OF THE PYROPHOSPHATE MOIETY

Chemischer Informationsdienst, 1979
AbstractIm Zusammenhang mit biogenetischen Untersuchungen wer ‐ den anhand von verschiedenen Versuchen mit 130 , [3H]‐ und [14C]‐markierten Verbindungen Mechanismus und Stereochemie der enzymatischen Umlagerung von Farnesyl ‐(I) zu Nerolidyl‐pyrophosphat (II) studiert und geklärt.
D. E. CANE, R. IYENGAR
openaire   +1 more source

Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue

European Journal of Cancer, 2000
Farnesylation of Ras is required for its transforming activity in human cancer and the reaction is catalysed by the enzyme farnesyltransferase. Recently, we discovered a novel chemical series of potent farnesyl pyrophosphate (FPP) analogues which selectively inhibited farnesyltransferase.
S K, Tahir, W Z, Gu, H C, Zhang, J, Leal, J Y, Lee, P, Kovar, B, Saeed, S P, Cherian, E, Devine, J, Cohen, R, Warner, Y C, Wang, D, Stout, D L, Arendsen, S, Rosenberg, S C, Ng   +15 more
openaire   +2 more sources

Substrate specificity of farnesyl pyrophosphate synthetase

Journal of the American Chemical Society, 1972
T, Nishino, K, Ogura, S, Seto
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Farnesyl pyrophosphate synthetase from Bacillus subtilis.

Journal of biochemistry, 1981
Farnesyl pyrophosphate synthetase was detected in extracts of Bacillus subtilis and partially purified by Sephadex G-100, hydroxylapatite, and DEAE-Sephadex chromatography. The enzyme catalyzed the exclusive formation of all-trans farnesyl pyrophosphate from isopentenyl pyrophosphate and either dimethylallyl or geranyl pyrophosphate. Mg2+ was essential
I, Takahashi, K, Ogura
openaire   +1 more source

Formation of 16,16'-bisnorgeranylgeranyl pyrophosphate by farnesyl pyrophosphate synthetase

Journal of the American Chemical Society, 1971
Shuichi Seto, Tokuzo Nishino, Kyozo Ogura   +2 more
openaire   +1 more source

Inactivation of undecaprenyl pyrophosphate synthetase with a photolabile analog of farnesyl pyrophosphate

Biochemistry, 1984
Tsuneo Baba, Charles M. Allen
openaire   +1 more source

The enzymic conversion of farnesyl to nerolidyl pyrophosphate: role of the pyrophosphate moiety

Journal of the American Chemical Society, 1979
David E. Cane, Radha Iyengar
openaire   +1 more source

Mechanism of squalene biosynthesis from mevalonate and farnesyl pyrophosphate

Biochemical and Biophysical Research Communications, 1961
G, POPJAK, D S, GOODMAN, J W, CORNFORTH, R H, CORNFORTH, R, RYHAGE   +4 more
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The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes

Biochemical and Biophysical Research Communications, 1960
D G, ANDERSON, M S, RICE, J W, PORTER
openaire   +2 more sources