Results 11 to 20 of about 6,653 (163)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective [PDF]

Frontiers in Chemistry, 2021
Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster class of drugs nitrogen-containing bisphosphonates represent one of the best-known examples. Widely used to treat bone-resorption disorders, these drugs work by inhibiting the enzyme
Jaeok Park, Vishal R. Pandya, Sean J. Ezekiel, Albert M. Berghuis   +3 more
openaire   +4 more sources

Functional Characterization of the Xanthophyllomyces dendrorhous Farnesyl Pyrophosphate Synthase and Geranylgeranyl Pyrophosphate Synthase Encoding Genes That Are Involved in the Synthesis of Isoprenoid Precursors

PLoS ONE, 2014
The yeast Xanthophyllomyces dendrorhous synthesizes the carotenoid astaxanthin, which has applications in biotechnology because of its antioxidant and pigmentation properties. However, wild-type strains produce too low amounts of carotenoids to be industrially competitive. Considering this background, it is indispensable to understand how the synthesis
Alcaíno Gorman, Jennifer, Cifuentes Guzmán, Víctor, Romero, Ignacio, Niklitschek, Mauricio, Sepúveda, Dionisia, Rojas Garrido, María Cecilia, Baeza Cancino, Marcelo   +6 more
openaire   +7 more sources

The Property of a Key Amino Acid Determines the Function of Farnesyl Pyrophosphate Synthase in Sporobolomyces pararoseus NGR. [PDF]

Curr Issues Mol Biol
Farnesyl pyrophosphate synthase (FPPS) catalyzes the synthesis of C15 farnesyl diphosphate (FPP) from C5 dimethylallyl diphosphate (DMAPP) and two or three C5 isopentenyl diphosphates (IPPs). FPP is an important precursor for the synthesis of isoprenoids
Wang Y, Zhang N, Yan J, Li C, Zeng N, Wang D, Li Z, Li B, An Y.   +8 more
europepmc   +2 more sources

Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling. [PDF]

J Int Med Res, 2020
Objectives Autophagy is divided into three phases: autophagosome engulfment of intracellular organelles and proteins, autophagosome fusion with lysosomes, and autolysosome degradation.
Han J, Huang C, Jiang J, Jiang D.
europepmc   +2 more sources

Computational study of the inhibitory potential of Gongronema latifolium (benth) leave on farnesyl pyrophosphate synthase, a target enzyme in the treatment of osteoporosis. A molecular modelling approach

Journal of Herbal Drugs, 2022
Background & Aim: Osteoporosis is an increasing medical threat which is referred to as a systemic skeletal disorder that is characterized mainly by low bone mass and microarchitectural wear of bone tissue and strength, which eventually results in an ...
Samuel O. Olubode, Bankole Mutolib , Precious Ayorinde Akinnusi , Wasiu A. Salaudeen , Kehinde I. Ojubola, Olayinka S. Adanlawo, Abigail Oluwakemi Ayodele , Adefunke O. Ogunlade, Abdullahi A. Aderemi   +8 more
doaj   +1 more source

Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase fromPseudomonas aeruginosa [PDF]

Acta Crystallographica Section D: Biological Crystallography, 2015
Robert Schnell
exaly   +2 more sources

Systematic characterization and functional analysis of <i>trans</i>-prenyltransferases in <i>Curcuma wenyujin</i>. [PDF]

Front Plant Sci
IntroductionCurcuma wenyujin (Zingiberaceae), a medicinally significant species within the Curcuma genus, is highly regarded in traditional Chinese medicine for its rich terpenoid constituents.
Wang Q, Su Y, Ye T, Wu S, Liu H, Sun J, Yin X, Hu T, Ma X, Zhao S, Xu X, Yin X, Wei Q.   +12 more
europepmc   +2 more sources

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells. [PDF]

BMC Cardiovasc Disord
Background Nitrogen-containing bisphosphonate(N-BP)had been found to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells (VSMCs), but the mechanism is not clear.
Xu W, Gong L, Tang W, Lu G.
europepmc   +2 more sources

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. [PDF]

PLoS One, 2017
Human farnesyl pyrophosphate synthase (hFPPS) catalyzes the production of the 15-carbon isoprenoid farnesyl pyrophosphate. The enzyme is a key regulator of the mevalonate pathway and a well-established drug target.
Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM.   +5 more
europepmc   +2 more sources

Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase [PDF]

Current Medicinal Chemistry, 2011
Bisphosphonates (BPs) are the most widely used and effective treatment for osteoporosis and Paget's disease. Non-nitrogen containing BPs (non-N-BPs), namely etidronate, clodronate, tiludronate, as well as nitrogen containing BPs (N-BPs), namely pamidronate, alendronate, ibandronate, risedronate, zoledronate and minodronate have been launched on the ...
Ohno, K, Mori, K, Orita, M, Takeuchi, M
openaire   +2 more sources