Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate [PDF]
Acta Crystallographica Section F, Structural Biology Communications, 2014 Tobias Erich Schrader +2 more
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Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase
Nature Communications, 2023 Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl pyrophosphate ...
Zhong Li +16 more
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Biological effects of trans, trans-farnesol in Leishmania amazonensis
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro +9 more
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Statistical experimental design guided optimization of a one-pot biphasic multienzyme total synthesis of amorpha-4,11-diene. [PDF]
PLoS ONE, 2013 In vitro synthesis of chemicals and pharmaceuticals using enzymes is of considerable interest as these biocatalysts facilitate a wide variety of reactions under mild conditions with excellent regio-, chemo- and stereoselectivities.
Xixian Chen +5 more
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Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
Cells, 2020 Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Nguyen Thi Ha, Chang Hoon Lee
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Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors
Advanced Biomedical Research, 2022 Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
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Bisphosphonates Are Potent Inhibitors of Trypanosoma cruzi Farnesyl Pyrophosphate Synthase [PDF]
Journal of Biological Chemistry, 2001 We report the cloning and sequencing of a gene encoding the farnesyl pyrophosphate synthase of Trypanosoma cruzi. The protein (T. cruzi farnesyl pyrophosphate synthase, TcFPPS) is an attractive target for drug development, since the growth of T. cruzi is inhibited by carbocation transition state/reactive intermediate analogs of its substrates, the ...
A, Montalvetti +5 more
openaire +2 more sources
Farnesyl pyrophosphate synthase modulators: a patent review (2006 – 2010) [PDF]
Expert Opinion on Therapeutic Patents, 2011 Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders characterized by excessive bone resorption ...
Shuting, Sun, Charles E, McKenna
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Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
AMB Express, 2022 Dendrobium nobile Lindl. has been used as a traditional Chinese medicine for a long time, in which the most important compound is dendrobine functioning in a variety of pharmacological activities.
Daoyong Gong +6 more
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Combinatorial transient gene expression strategies to enhance terpenoid production in plants
Frontiers in Plant Science, 2022 IntroductionThe monoterpenoid linalool and sesquiterpenoid costunolide are ubiquitous plant components that have been economically exploited for their respective essential oils and pharmaceutical benefits.
Soyoung Park +4 more
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