Results 71 to 80 of about 115,762 (301)

Fas and Fas Ligand Gene Mutations in Hashimoto's Thyroiditis [PDF]

Laboratory Investigation, 2002
To clarify whether Fas and Fas ligand (FasL) mutations are involved in the pathogenesis of Hashimoto's thyroiditis (HT), we examined the open reading frame of Fas and FasL in 21 cases. Mutations of Fas and FasL genes were detected in 8 (38.1%) and 1 (4.8%) of 21 cases, respectively.
Zhiming, Dong, Tetsuya, Takakuwa, Hitoshi, Takayama, Wen-Juan, Luo, Toru, Takano, Nobuyuki, Amino, Fumio, Matsuzuka, Katsuyuki, Aozasa   +7 more
openaire   +2 more sources

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects [PDF]

, 2008
Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors.
Köhler, Barbara, Anguissola, Sergio, Concannon, Caoimhin G., Rehm, Markus, Kögel, Donat, Prehn, Jochen H. M.   +5 more
core   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Alteration of Regulation of Fas/FasL Mediated Apoptosis in Gastric Cancer [PDF]

Revista Ciencias de la Salud, 2009
Gastric cancer is an important neoplasticdisease in all around the world because its highincidence and mortality. Otherwise, apoptosis isa key process of programmed cell death duringembryogenesis, regulation of immune system,and holding the tissue ...
Reggie García Robles, Paola Ayala Ramírez, Natalia Acosta Vega   +2 more
doaj  

Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses [PDF]

, 2000
Ligation of the Fas (CD95) receptor leads to an apoptotic death signal in T cells, B cells, and macrophages. However, human CD34(+)-derived dendritic cells (DCs) and mouse DCs, regardless of their maturation state, are not susceptible to Fas-induced cell
Alderson, Allison, Arrighi, Ashany, Ashany, Banchereau, Barbara Valzasina, Chervonsky, Citterio, De Maria, De Smedt, Holler, Iezzi, Irmler, Jurg Tschopp, Kataoka, Kennedy, Lars French, Lynch, Maria Rescigno, Matsue, Miwa, Paola Ricciardi-Castagnoli, Piguet, Rescigno, Richardson, Rothstein, Rudolf Zubler, Schmid, Stassi, Suda, Suzanne Lens, Takahashi, Tschopp, Vincent Kindler, Vincent Piguet, Willems, Winzler   +37 more
core   +1 more source

Cholangiocarcinomas express fas ligand and disable the fas receptor [PDF]

Hepatology, 1999
Cholangiocarcinoma is a highly-malignant adenocarcinoma originating from cholangiocytes. Current concepts support escape from immune surveillance using aberrant expression of Fas ligand (FasL) and dysregulation of receptor (FasR) signaling as a potential mechanism for tumor progression.
F G, Que, V A, Phan, V H, Phan, A, Celli, K, Batts, N F, LaRusso, G J, Gores   +6 more
openaire   +2 more sources

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

Cell Reports, 2020
Summary: Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation.
Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner   +5 more
doaj   +1 more source

The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. [PDF]

PLoS ONE, 2013
Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe).
Xiaodong Huang, Zhaohui Lu, Zhongwei Lv, Tingting Yu, Peirong Yang, Yongnian Shen, Yu Ding, Da Fu, Xiaoping Zhang, Qihua Fu, Yongguo Yu   +10 more
doaj   +1 more source