Results 81 to 90 of about 598,280 (274)

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo, Jinyin Yan, Wenli Li, Jin Wang, Lu Liu, Chengmei Zhang, Wei Cao, Shanshan Yao, Haibo Gong, Yi He, Zihan Zhou, Siyan Chen, Li Feng, Haijing Deng   +13 more
wiley   +1 more source

Role of Fas/Fas Ligand Pathway in a Sample of Iraqi Diabetic Foot Patients

Diyala Journal of Medicine, 2019
Background: Diabetic foot (DF) is one of diabetes mellitus (DM) complication, it is delayed wound healing and may end with amputation of limbs. Involvement of Fas/Fas ligand (FasL) pathway in the pathogenesis of diabetic complications has been proposed.
Sabah Khorsheed Hussian , Isam Noori Al-Karawi , Khalid Shalaan Sahab   +2 more
doaj   +2 more sources

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

Cell Reports, 2020
Summary: Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation.
Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner   +5 more
doaj   +1 more source

Fas Ligand Expression in the Organ of Corti [PDF]

Audiology and Neurotology, 2003
We have previously demonstrated by FACS analysis and histochemistry that Fas ligand (FasL) increases on cochlear cell surfaces after immune response or stimulation with γ-interferon (IFN-γ). To determine whether the appearance of FasL on cochlear cell membranes is related to gene expression or to posttranslational events, cochlear cells were treated ...
Bodmer, Daniel, Brors, Dominik, Bodmer, Morana, Pak, Kwang, Ryan, Allen F.   +4 more
openaire   +3 more sources

Oxidative stress increases Fas ligand expression in endothelial cells

Journal of Inflammation, 2006
Background Fas ligand (FasL) induces apoptosis in Fas-bearing target cells, such as leukocytes, and up-regulation of FasL expression on the endothelium may contribute to anti-inflammatory reactions that attenuate leukocyte extravasation during ...
Nagai Atsushi, Aoshiba Kazutetsu, Suzuki Mayumi   +2 more
doaj   +1 more source

The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. [PDF]

PLoS ONE, 2013
Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe).
Xiaodong Huang, Zhaohui Lu, Zhongwei Lv, Tingting Yu, Peirong Yang, Yongnian Shen, Yu Ding, Da Fu, Xiaoping Zhang, Qihua Fu, Yongguo Yu   +10 more
doaj   +1 more source

The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice [PDF]

, 2005
Background: Although previous studies have shown that the hepatic sympathetic nerve controls various physiological functions in the liver, the role of this nerve in liver injury has yet to be clarified.Aims: The purpose of this study was to elucidate the
Chida, Y, Takaki, A, Kubo, C, Sudo, N
core  

Combined Treatment with Denbinobin and Fas Ligand Has a Synergistic Cytotoxic Effect in Human Pancreatic Adenocarcinoma Bxpc-3 Cells

, 2010
Background and purpose: Human pancreatic carcinoma is a highly malignant cancer. Previous studies have shown that the decoy receptor 3 (DcR3) for Fas ligand (FasL) plays significant roles in tumour progression and immune suppression. In the present study,
楊家榮;鄧哲明;陳姵璇, Yang, CR; Guh, JH; Teng, CM; Chen, CC; Chen, PH   +1 more
core   +1 more source

Investigating the Effect of Mid-Term of Aerobic Exercise on Apoptosis Biomarkers in the Cardiomyocytes of Streptozotocin-Induced Diabetic Rats [PDF]

Journal of Advanced Biomedical Sciences, 2017
Background & Objective: Apoptosis plays a major role in the process of diabetes-induced heart disease, but the effects of aerobic intermediate exercises on the status of apoptosis in diabetics’ cardiomyocytes are unclear.
Saeed Tanoorsaz, Naser Behpour, Vahid Tadibi   +2 more
doaj  

Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts

, 2006
Fas (CD95/Apo-1) ligand-mediated apoptosis induction of target cells is one of the major effector mechanisms by which cytotoxic lymphocytes (T cells and natural killer cells) kill their target cells. In T cells, Fas ligand expression is tightly regulated
Legler, Daniel F, Thomas Brunner, Daniel F. Legler, Kassahn, Daniela, Shida Yousefi, Yousefi, Shida, Brunner, Thomas, Daniela Kassahn, Nachbur, Ueli, Ueli Nachbur, Legler, Daniel F.   +10 more
core   +1 more source