Results 71 to 80 of about 1,159,722 (286)

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

Cell Reports, 2020
Summary: Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation.
Carlos A. Donado, Anh B. Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner   +5 more
doaj   +1 more source

The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. [PDF]

PLoS ONE, 2013
Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe).
Xiaodong Huang, Zhaohui Lu, Zhongwei Lv, Tingting Yu, Peirong Yang, Yongnian Shen, Yu Ding, Da Fu, Xiaoping Zhang, Qihua Fu, Yongguo Yu   +10 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Role of Fas/Fas Ligand Pathway in a Sample of Iraqi Diabetic Foot Patients

Diyala Journal of Medicine, 2019
Background: Diabetic foot (DF) is one of diabetes mellitus (DM) complication, it is delayed wound healing and may end with amputation of limbs. Involvement of Fas/Fas ligand (FasL) pathway in the pathogenesis of diabetic complications has been proposed.
Sabah Khorsheed Hussian , Isam Noori Al-Karawi , Khalid Shalaan Sahab   +2 more
doaj   +2 more sources

Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation

Journal of Allergy and Clinical Immunology, 2012
Background Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic nonmalignant lymphoproliferation, accumulation of double-negative T cells, hypergammaglobulinemia G and A, and autoimmune cytopenia.
A. Magerus-Chatinet, M. Stolzenberg, Nina Lanzarotti, B. Neven, C. Daussy, C. Picard, N. Neveux, M. Desai, Meghana Rao, K. Ghosh, M. Madkaikar, A. Fischer, F. Rieux-Laucat   +12 more
semanticscholar   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Oxidative stress increases Fas ligand expression in endothelial cells

Journal of Inflammation, 2006
Background Fas ligand (FasL) induces apoptosis in Fas-bearing target cells, such as leukocytes, and up-regulation of FasL expression on the endothelium may contribute to anti-inflammatory reactions that attenuate leukocyte extravasation during ...
Nagai Atsushi, Aoshiba Kazutetsu, Suzuki Mayumi   +2 more
doaj   +1 more source

Fas Ligand Expression in the Organ of Corti [PDF]

Audiology and Neurotology, 2003
We have previously demonstrated by FACS analysis and histochemistry that Fas ligand (FasL) increases on cochlear cell surfaces after immune response or stimulation with γ-interferon (IFN-γ). To determine whether the appearance of FasL on cochlear cell membranes is related to gene expression or to posttranslational events, cochlear cells were treated ...
Bodmer, Daniel, Brors, Dominik, Bodmer, Morana, Pak, Kwang, Ryan, Allen F.   +4 more
openaire   +3 more sources

Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of  TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells

Journal of Experimental Medicine, 1998
Mature natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of cytotoxic proteins, Fas ligand (FasL), and membrane-bound or secreted cytokines (tumor necrosis factor [TNF]-α) to induce target cell death.
L. Zamai, Manzoor Ahmad, I. Bennett, L. Azzoni, E. Alnemri, B. Perussia   +5 more
semanticscholar   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source