Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease. [PDF]
Blood Adv, 2023 Key Points • Donor T cells engineered to display on their surface SA-FasL protein undergo apoptosis after activation by host alloantigens.• SA-FasL on donor lymphocytes effectively prevents acute GVHD.
Shrestha P +8 more
europepmc +6 more sources
p38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression [PDF]
Journal of Biological Chemistry, 1999 p38 mitogen-activated protein kinase (MAPK) is activated by T cell receptor engagement. Here we showed that T cell receptor activated p38α but not p38δ.
Shu‐Ching Hsu +4 more
semanticscholar +5 more sources
Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation [PDF]
Journal of Biological Chemistry, 2014 Background: PEDF has attracted attention for its direct antitumor effect. Results: The p53-mediated cell surface translocation of Fas and up-regulation of Fas-L contributes to PEDF-induced apoptosis.
Lei Li +15 more
semanticscholar +5 more sources
Interaction of the Adenovirus 14.7-kDa Protein with FLICE Inhibits Fas Ligand-induced Apoptosis [PDF]
Journal of Biological Chemistry, 1998 Adenovirus type 5 encodes a 14.7-kDa protein that protects infected cells from tumor necrosis factor-induced cytolysis by an unknown mechanism. In this report, we demonstrate that infection of cells with an adenovirus vector expressing Fas ligand induced
Ping Chen +3 more
semanticscholar +4 more sources
FAS Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-Activated Protein Kinase [PDF]
The Journal of Experimental Medicine, 2000 The short life span of granulocytes, which limits many inflammatory responses, is thought to be influenced by the Bcl-2 protein family, death receptors such as CD95 (Fas/APO-1), stress-activated protein kinases such as p38 mitogen-activated protein ...
Andreas Villunger +4 more
semanticscholar +4 more sources
Regulation of FAS Ligand Expression during Activation-Induced Cell Death in T Cells by p38 Mitogen-Activated Protein Kinase and C-Jun Nh2-Terminal Kinase [PDF]
Journal of Experimental Medicine, 2000 Activation-induced cell death (AICD) is a mechanism of peripheral T cell tolerance that depends upon an interaction between Fas and Fas ligand (FasL).
Jian Zhang +7 more
openalex +2 more sources
The role of Fas ligand protein in the oxidative stress induced by azoxymethane on crypt colon of rats O papel da proteína ligante Fas no estresse oxidativo induzido pelo azoximetano em criptas do colo de ratos [PDF]
Acta Cirúrgica Brasileira, 2010 PURPOSE: To study the protein Fas ligand (FasL) on the expression of apoptosis, using a model of oxidative stress induced by azoxymethane (AOM), in the crypt of colon in rats.
Luiz Antonio Maksoud Bussuan +4 more
doaj +2 more sources
Protein Kinase Cθ Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death [PDF]
Journal of Immunology, 1999 Activation-induced cell death is mediated by the TCR-induced expression of the Fas ligand (FasL) on the surface of T cells, followed by binding to its receptor Fas. FasL expression is induced by stimulating T cells with a combination of phorbol ester and
Martín Villalba +5 more
openalex +2 more sources
The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins [PDF]
BMC Neuroscience, 2004 Background Apoptosis is important for normal cerebral cortical development. We previously showed that the Fas suicide receptor was expressed within the developing cerebral cortex, and that in vitro Fas activation resulted in caspase-dependent death ...
Newman Joseph M +4 more
doaj +2 more sources
Corticotropin-releasing Hormone Induces Fas Ligand Production and Apoptosis in PC12 Cells via Activation of p38 Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 2002 Recent experimental findings involve corticotropin-releasing hormone (CRH) in the cellular response to noxious stimuli and possibly apoptosis. The aim of the present work was to examine the effect of CRH on apoptosis and the Fas/Fas ligand system in an ...
Erini Dermitzaki +3 more
openalex +2 more sources