Results 1 to 10 of about 106,589 (211)

Fas induces apoptosis in human coronary artery endothelial cells in vitro [PDF]

BMC Cell Biology, 2004
Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi, Dincer Erhan, Gidea Claudia, Ang Edmund, Filippatos Gerasimos, Uhal Bruce D   +5 more
doaj   +3 more sources

CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans [PDF]

EMBO Reports
The transmembrane protein CMTM6 promotes plasma membrane expression of the immune checkpoint protein PD-L1, a key suppressor of anti-tumor immunity. Targeting CMTM6 has been proposed as a strategy to enhance tumor cell killing by reducing PD-L1 surface ...
Tereza Semberova, Michaela Pribikova, Veronika Cimermanova, Tijana Trivic, Rafik Haderbache, Darina Paprckova, Luca Christen, Helena Kissiova, Ondrej Stepanek, Peter Draber   +9 more
doaj   +2 more sources

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. [PDF]

PLoS ONE, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Gwenaëlle Fillon, Amanda Gysbers, Hanne D Hansen, Manuela Neumann, Christiane Richter-Landsberg, Christian Haass, Bernard Zalc, Catherine Lubetzki, Wei-Ping Gai, Glenda M Halliday, Philipp J Kahle, Poul H Jensen   +12 more
doaj   +6 more sources

Role of Apoptotic Biomarkers in Ameloblastoma and Dental Follicle

Journal of Dental School, 2021
Objectives Ameloblastoma is an odontogenic neoplasm with locally aggressive behavior. Fas and FasL play important roles in apoptotic pathways. The aim of this study was to determine the possible role of expression of apoptotic pathways (Fas and FasL) in
Fatemeh Mashhadiabbas, Roohallah Safarpour, Hakimeh Ghorbani   +2 more
doaj   +1 more source

Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Infection with high-risk human papillomavirus is required to develop cervical cancer. Some viruses modulate the Fas/FasL signaling to evade the immune response; the role of these molecules in cervical cancer is not clear.
Carla O Contreras-Ochoa, Margarita Bahena-Román, Luz Yvette López-Díaz, Alfredo Lagunas-Martínez, Carlos Mojica-Cardoso, Joaquín Manzo-Merino, Kirvis Torres-poveda, Vicente Madrid-Marina   +7 more
doaj   +1 more source

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

Cells, 2022
Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity.
Nicholas Frazzette, Anthony C. Cruz, Xufeng Wu, John A. Hammer, Jennifer Lippincott-Schwartz, Richard M. Siegel, Prabuddha Sengupta   +6 more
doaj   +1 more source

Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain

Neurobiology of Disease, 2021
Introduction: Alterations of white matter integrity and subsequent white matter structural deficits are consistent findings in Fetal Alcohol Syndrome (FAS), but knowledge regarding the molecular mechanisms underlying these abnormalities is incomplete ...
Nune Darbinian, Armine Darbinyan, Nana Merabova, Ahsun Bajwa, Gabriel Tatevosian, Diana Martirosyan, Huaqing Zhao, Michael E. Selzer, Laura Goetzl   +8 more
doaj   +1 more source

Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins. [PDF]

, 2015
GIV/Girdin is a multimodular signal transducer and a bona fide metastasis-related protein. As a guanidine exchange factor (GEF), GIV modulates signals initiated by growth factors (chemical signals) by activating the G protein Gαi.
Ghosh, Pradipta, Kabir, Firooz, Kalogriopoulos, Nicholas, Lo, I-Chung, Lopez-Sanchez, Inmaculada, Midde, Krishna K, Wang, Honghui   +6 more
core   +1 more source

Transfer of Fas (CD95) protein from the cell surface to the surface of polystyrene beads coated with anti-Fas antibody clone CH-11

European Journal of Histochemistry, 2010
Mouse monoclonal anti-Fas (CD95) antibody clone CH-11 has been widely used in research on apoptosis. CH-11 has the ability to bind to Fas protein on cell surface and induce apoptosis.
H. Sawai, N. Domae
doaj   +1 more source

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening

BMC Immunology, 2009
Background - Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins.
Lettau Marcus, Voss Matthias, Janssen Ottmar   +2 more
doaj   +1 more source