The Mouse Cell Surface Protein TOSO Regulates Fas/Fas Ligand-induced Apoptosis through Its Binding to Fas-associated Death Domain* [PDF]
Journal of Biological Chemistry, 2005 Mouse TOSO, the homologue of human TOSO gene, was cloned and characterized in the present study. Using immunofluorescence confocal microscopy we localized TOSO to the cytoplasmic membrane of expressing cells.
Yahui Song, C. Jacob
semanticscholar +3 more sources
Localization and Trafficking of the Death-Inducing Fas Ligand Protein in Cytotoxic T Lymphocytes
, 2014 Cytotoxic T lymphocytes (CTL) can kill tumor cells and cells infected with intracellular pathogens. Their two major killing mechanisms are the degranulation pathway and the Fas-FasL pathway. The degranulation process consists of the release of cytolytic perforin and granzyme molecules that are stored within lysosomal granules.
Ana L. Clementín
semanticscholar +3 more sources
Arsenic Induces Human Keratinocyte Apoptosis by the FAS/FAS Ligand Pathway, Which Correlates with Alterations in Nuclear Factor-κB and Activator Protein-1 Activity [PDF]
Journal of Investigative Dermatology, 2004 Wei‐Ting Liao +5 more
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Proceedings of the National Academy of Sciences of the United States of America, 2006 Marcus Lettau +6 more
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The Expression of Fas Ligand Protein in Ultraviolet-Exposed Rabbit Corneas
Cornea, 2002 Keratocytes undergo apoptosis during various pathologic conditions and after exposure to ultraviolet radiation (UVR). It was reported that the Fas/Fas ligand system is involved in modulating keratocyte apoptosis. The expression of Fas ligand (FasL) protein was studied in rabbit corneas after photokeratitis induced by different UV wavelengths.Six New ...
A. Podskochy, P. Fagerholm
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Survivin Enhances Fas Ligand Expression via Up-Regulation of Specificity Protein 1-Mediated Gene Transcription in Colon Cancer Cells [PDF]
Journal of Immunology, 2004 Koichi Asanuma +4 more
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The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis1 [PDF]
The Journal of Immunology, 2007 Abstract A functional immune system not only requires rapid expansion of antigenic specific T cells, but also requires efficient deletion of clonally expanded T cells to avoid accumulation of T cells. Fas/Fas ligand (FasL)-mediated apoptosis plays a critical role in the deletion of activated peripheral T cells, which is clearly ...
S. Manicassamy, Zuoming Sun
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Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice [PDF]
Journal of Clinical Investigation, 2003 Julia I-Ju Leu +2 more
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A Novel Polymorphic CAAT/Enhancer-Binding Protein β Element in the FasL Gene Promoter Alters Fas Ligand Expression: A Candidate Background Gene in African American Systemic Lupus Erythematosus Patients [PDF]
Journal of Immunology, 2003 Jianming Wu +9 more
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Role of Apoptotic Biomarkers in Ameloblastoma and Dental Follicle
Journal of Dental School, 2021 Objectives Ameloblastoma is an odontogenic neoplasm with locally aggressive behavior. Fas and FasL play important roles in apoptotic pathways. The aim of this study was to determine the possible role of expression of apoptotic pathways (Fas and FasL) in
Fatemeh Mashhadiabbas +2 more
doaj +1 more source