FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis [PDF]
Cell Death Discovery, 2022 Pulmonary metastasis occurring via the colonization of circulating cancer stem cells is a major cause of oral squamous cell carcinoma (OSCC)-related death.
Li-Jie Li +9 more
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The Role of FAS Receptor Methylation in Osteosarcoma Metastasis. [PDF]
Int J Mol Sci, 2023 Osteosarcoma is the most frequent primary malignant bone tumor with an annual incidence of about 400 cases in the United States. Osteosarcoma primarily metastasizes to the lungs, where FAS ligand (FASL) is constitutively expressed. The interaction of FASL and its cell surface receptor, FAS, triggers apoptosis in normal cells; however, this function is ...
Sun JM +18 more
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SIGNALING THROUGH THE DEATH RECEPTOR CD95 (APO-1/FAS) [PDF]
TheScientificWorldJOURNAL, 2001 INTRODUCTION AND METHOD. Using classical immunoprecipitation protocols in combination with high-resolution 2D gels, we identified a complex of proteins that formed around the death domain of the stimulated death receptor CD95 (APO-1/Fas) receptor which we called the death-inducing signaling complex (DISC)(1).
Marcus E. Peter
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Fas receptor is not present on ejaculated human sperm [PDF]
Human Reproduction, 2008 Apoptosis appears to have an essential role in the control of testis germ cell number and Fas expression has been reported in apoptotic spermatocytes and spermatids. We investigated if Fas (CD95) was present on ejaculated human sperm and any relationship between Fas on sperm and the apoptotic marker Syto16.Semen samples from 77 male partners of ...
Sandra Perticarari +6 more
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The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. [PDF]
PLoS ONE, 2013 Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe).
Xiaodong Huang +10 more
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A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma [PDF]
Journal of Neuroinflammation, 2019 Background Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration.
Anitha Krishnan +4 more
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MicroRNA-181c prevents apoptosis by targeting of FAS receptor in Ewing's sarcoma cells. [PDF]
Cancer Cell Int, 2018 Kawano M +4 more
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Swapping between Fas and Granulocyte Colony-stimulating Factor Receptor [PDF]
Journal of Biological Chemistry, 1996 Fas belongs to the tumor necrosis factor/nerve growth factor receptor family. The Fas ligand binds to its receptor, Fas, and induces apoptosis in Fas-bearing cells. The granulocyte colony-stimulating factor receptor (G-CSFR) is a member of the hemopoietic growth factor receptor family.
Tomohiro Takahashi +5 more
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Preservation of retinal structure and function in two mouse models of inherited retinal degeneration by ONL1204, an inhibitor of the Fas receptor. [PDF]
Cell Death DisYang M +4 more
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Folia Histochemica et Cytobiologica, 2005 In recent years many data indicate that lymphocytes from cancer patients undergo increased apoptosis. The objective of this study was to evaluate the expression of Fas receptor on lymphocytes obtained from patients with lung cancer.
Joanna Domagała-Kulawik +2 more
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