Results 31 to 40 of about 386,393 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Warning Label and Video Efficacy on High School Student Consumption of Soft Drink and Fast Food

open access: yesJournal of Consumer Sciences, 2019
Excessive consumption of fast food and soft drink causes various negative impacts on health. This study aims to analyze the knowledge and intention toward fast food and soft drinks consumption on adolescents.
Ujang Sumarwan   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Distribuição física de produtos em uma empresa de fast food [PDF]

open access: yes, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Campus Joinville. Engenharia de Transportes e Logística.O ramo alimentício de fast food vem crescendo e exigindo maior competitividade das empresas neste setor, as quais frequentemente buscam ...
Silva, Luiza Fuhrmann Kehrig
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

TAX INCENTIVES FROM INCOME TAXES IN ATTRACTING FOREIGN INVESTMENT IN SERBIA

open access: yesActa Economica, 2009
The aim of this paper is to point out the tax incentives from the tax, which are often used in the transition countries, especially in Serbia, for attracting foreign investment. The paper analyzes the theoretical aspect of the tax incentives from the get
Драган М. Момировић, PhD   +1 more
doaj  

Development of a Vegan Soybean-Based Yoghurt Alternative Using Levilactobacillus brevis QD-1 and Saccharomyces cerevisiae as the Starter Culture for Improved Texture and Aroma Profile

open access: yesPolish Journal of Food and Nutrition Sciences
This study aimed to develop a vegan soybean yoghurt alternative using co-cultures of Levilactobacillus bre vis QD-1 and Saccharomyces cerevisiae , and to evaluate their effects on textural properties, protein structure, and aroma profile of the end ...
Thanh Sang Nguyen   +4 more
doaj   +1 more source

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