Results 51 to 60 of about 4,542 (299)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Pengaruh tingkat penambahan whey protein concentrate pada low-fat ice cream dengan modified tapioca starch sebagai fat replacer [PDF]

open access: yes, 2010
Low-fat ice cream memiliki kandungan lemak yang rendah, yaitu 2-4%. Rendahnya kandungan lemak pada low-fat ice cream akan berpengaruh terhadap karakteristik fisikokimia dan organoleptik ice cream yang tidak diinginkan.
Linardi, Rosa Angelia
core  

Effect of feeding liquid milk supplement on litter performances and on sow back-fat thickness change during the suckling period [PDF]

open access: yesArchives Animal Breeding, 2015
The aim of the present study was to investigate the effect of liquid milk supplement on litter performance (weight development of the piglets, weaning weight and mortality) and on sow back-fat thickness change during the suckling period.
G. Novotni-Dankó   +3 more
doaj   +1 more source

Chia (Salvia hispanica L.) seed mucilage as a fat replacer in yogurts: Effect on their nutritional, technological, and sensory properties

open access: yes, 2021
[EN] Growing consumer demand for healthy and nutritious products has motivated scientists and food manufacturers to design novel dairy products with higher fiber levels and lower fat content that are free of chemical additives.
Talens Oliag, Pau   +4 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Effects of fat level and coconut-to-palm fat ratio in milk replacer on solid feed intake and performance of pre- and postweaning dairy calves

open access: yesJournal of Dairy Science
: This study investigated the effects of varying fat levels and ratios of coconut to palm fat in milk replacer on solid feed intake and performance of male Holstein calves fed a high milk replacer allowance.
J.V.R. Lovatti   +5 more
doaj   +1 more source

EFFECT OF USING ARTICHOKE AS A SOURCE OF INULIN ON LOW CALORIE ICE CREAM QUALITY [PDF]

open access: yesJournal of Food and Dairy Sciences, 2015
The effect of artichoke as a source of inulin which is used as a fat replacer on physic-chemical characteristics and sensory attributes of ice cream with different level of fat (12, 9, and 6%) with 11% SNF were investigated.
W. Nasr   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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