Results 201 to 210 of about 799,214 (269)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

KRAS Signaling Inhibition Induces a Targetable Metabolic Dependency on Lipophagy-Dependent Fatty Acid Oxidation in Pancreatic Cancer. [PDF]

Cancer Res
Thakur R, Wang D, Hu T, He C, Zhao J, Suresh V, Rajacharya GH, Pradhan AK, Chumak V, Valenzuela CA, Kushwaha AD, LaBreck DA, Oh TG, Fung KM, Zhao D, Takebe N, Ulahannan SV, Shukla SK, Bryant KL, Der CJ, Mehla K, Singh PK.   +21 more
europepmc   +1 more source

Physicochemical Properties, Bioactive Components and Volatile Compounds of Dietary Fatty Acid Balanced Blend Oil. [PDF]

Foods
Liu E, Niu Q, Lu L, Geng L, Yang J, Yao H, Zhao Z.   +6 more
europepmc   +1 more source

Abiotic stress effects on polyunsaturated fatty acid biosynthesis in Chlorococcum oleofaciens and Leptolyngbya sp. [PDF]

Appl Microbiol Biotechnol
Chaudhary N, Mishra M, Yadav AK, Singh NK.   +3 more
europepmc   +1 more source

Fatty acid transporter protein isoform 2 (FATP2) inhibitor lipofermata inhibits Zika virus replication and blocks fatty acid uptake in SH-SY5Y neuroblastoma cell line. [PDF]

Microbiol Spectr
Thongon S, Boonarkart C, Sirihongthong T, Jitobaom K, Kongmanas K, Auewarakul P.   +5 more
europepmc   +1 more source

CPT1B promotes acute myeloid leukemia progression via fatty acid oxidation-dependent metabolic reprogramming. [PDF]

Transl Oncol
Cao R, Zhou LL, Liu Q, Liu GE, Xu L, He H.   +5 more
europepmc   +1 more source

Effect of Fatty Acid Chain Modification on the Self-Assembly Behavior and Antimicrobial Activity of Antimicrobial Peptides. [PDF]

Antibiotics (Basel)
Yang H, Luo M, Min Y, Zheng Y, Xu Y, Duan B, Pan F, Lu K.   +7 more
europepmc   +1 more source

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Partition of fatty acids and fluorescent fatty acids into membranes

Biochemistry, 1984
We have measured the membrane/water partition of free fatty acids, of a fluorescent analogue, and of chlorpromazine into plasma membranes from lymphoma, platelets, red cells, and liposomes of egg phosphatidylcholine. Three different methods were used: hygroscopic desorption [ Conrad , M.J., & Singer, S.J. (1979) Proc. Natl. Acad. Sci. U.S.A.
W J, Pjura, A M, Kleinfeld, M J, Karnovsky   +2 more
openaire   +2 more sources

Fatty Acids: Fatty Acids

2016
Fatty acids (FAs) are long hydrocarbon chain molecules with a terminal carboxylate group, originating from the organism or food. Their nomenclature, structure, and properties depend on the length of hydrocarbon chain, degree of unsaturation, and position of double bond(s).
Petrović, Snježana, Arsić, Aleksandra
openaire   +2 more sources