Results 211 to 220 of about 3,736,253 (314)

Activation of human brown adipocytes alters the plasma fatty acid profile. [PDF]

Front Mol Biosci
Miniewska K, Mojsak P, Chmielewska S, Choinska P, Godzien J, Labieniec L, Andrejczuk A, Hannukainen J, Oikonen V, Virtanen K, Nuutila P, Ciborowski M, Maliszewska K, Kretowski AJ.   +13 more
europepmc   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Regioselective epoxidation of a polyunsaturated fatty acid by a vanadyl complex with redox-active ligands.

Chem Commun (Camb)
Hill AG, Tang TY, Knight CM, Engle KS, Bernbeck MG, Soper JD, Das A.   +6 more
europepmc   +1 more source

Fatty Acid Profile of Table Grapes: Impact of Cultivar and Fruit Protection on Saturated, Monounsaturated, and Polyunsaturated Fatty Acid Profile. [PDF]

Foods
Coronel Montesdeoca NT, Andreu-Coll L, Jácome Sarchi GA, Hernández F, Sendra E.   +4 more
europepmc   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Treatment of Fatty Acid Oxidation Disorders Today: Emerging Personalized Treatment Strategies. [PDF]

J Inherit Metab Dis
Spiekerkoetter U, Vockley J.
europepmc   +1 more source