Results 61 to 70 of about 6,167,446 (362)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Unsaturated fatty acids [PDF]

, 2016
Fatty acids are long-chain hydrocarbons. They are called unsaturated fatty acids when they lack the maximum possible number of hydrogen atoms attached to every carbon atom. For example, if stearic acid, which has 18 carbon atoms and frequently occurs in animal and plant fats, is missing 2 hydrogen atoms, then a double bond is present and the resulting ...
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A large database linking the rumen bacterial composition and milk traits in Lacaune sheep

Scientific Data, 2023
Measurement(s) milk yield • milk somatic cell quantity • mid-infrared spectroscopy • Fat content • Protein content • milk fatty acid C4:0 amount • milk fatty acid C6:0 amount • milk fatty acid C8:0 amount • milk fatty acid C10:0 amount • milk fatty acid ...
Guillermo Martinez Boggio, Christel Marie-Etancelin, Jean-Marie Menras, Regis Tomas, Marie-Luce Chemit, Béatrice Gabinaud, Géraldine Pascal, Annabelle Meynadier   +7 more
doaj   +1 more source

Polyunsaturated Fatty Acids. IV.

Journal of Japan Oil Chemists' Society, 1960
Infrared absorption spectra of polyunsaturated fatty acid esters obtained from cuttle fish oils, showed a characteristic absorption at 1395cm-1, in addition to the typical absorption of normal fatty acid methylesters. This absorption at 1395cm-1 was related to the double bond, since by hydrogenation or autoxidation it was vanished away.Methyl linoleate,
Takaharu MIYAKAWA, Hideo NOMIZU
openaire   +4 more sources

From Phase Change Materials to Green Solvents: Hydrophobic Low Viscous Fatty Acid-based Deep Eutectic Solvents

, 2018
Inspired by the use of fatty acids in development of low temperature latent heat storage materials, novel low viscous and hydrophobic deep eutectic solvents (DESs) based exclusively on fatty acids are herein proposed as sustainable solvents.
C. Florindo, Leila Romero, I. Rintoul, L. Branco, I. Marrucho   +4 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Fatty acids composition in Pistachio [PDF]

BIO Web of Conferences
Pistachio (Pistacia vera L.), is an important food source for human health. It has nutritional content rich in protein, fat, fatty acids, fiber, vitamins and minerals. Such as other nuts, pistachio oil is rich in unsaturated fatty acids.
Gündüz Leyla Nurefşan, Kazan Murat, Topçu Hayat, Kafkas Salih   +3 more
doaj   +1 more source

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

Nature Communications, 2018
Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid ...
Alida Kindt, G. Liebisch, T. Clavel, D. Haller, G. Hörmannsperger, H. Yoon, Daniela Kolmeder, A. Sigruener, S. Krautbauer, Claudine Seeliger, A. Ganzha, S. Schweizer, Rosalie Morisset, T. Strowig, H. Daniel, D. Helm, B. Küster, J. Krumsiek, J. Ecker   +18 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source