Results 81 to 90 of about 1,711,548 (361)

Generation of cloned transgenic pigs rich in omega-3 fatty acids [PDF]

, 2006
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase.
August Rieke, Clifton N Murphy, David M Wax, Hwan Yul Yong, Jing X Kang, Jingdong Wang, JP Spychalla, JX Kang, L Lai, Liangxue Lai, Melissa Samuel, Michael L Linville, PRC Howe, Randall S Prather, Rhobert W Evans, Rongfeng Li, Scott W Korte, Thomas E Starzl, William T Witt, Y Dai, Yanhong Hao, Yifan Dai   +21 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Engineering yeast for tailored fatty acid profiles

Applied Microbiology and Biotechnology
The demand for sustainable and eco-friendly alternatives to fossil and plant oil-derived chemicals has spurred interest in microbial production of lipids, particularly triacylglycerols, fatty acids, and their derivatives.
Simon Kobalter, Tamara Wriessnegger, Harald Pichler   +2 more
doaj   +1 more source

Organic vs Conventional Suckling Lamb Production: Product Quality and Consumer Acceptance [PDF]

, 2008
Samples of suckling lambs (n=40) of two breeds reared under conventional and organic conditions were analysed to asses physico-chemical characteristics, including instrumental texture, and nutritional quality in terms of fatty acid composition.
Lurueña-Martínez, M.A., Palacios, C., Revilla, I., Severiano-Pérez, P., Vivar-Quintana, A.M.   +4 more
core  

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]

, 2014
The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D., Milligan, Graeme, Shimpukade, Bharat, Ulven, Trond   +3 more
core   +1 more source

Fatty Acids

, 2021
Milk fat is one of the most complex lipid matrices, with more than 400 different fatty acids (FA) in its composition and most of them at trace levels. In the past decades, important achievements have been achieved in regard to dairy fat FA analysis due to the remarkable development of modern analytical techniques.
Gómez-Cortés, Pilar, Juárez, Manuela, Fuente, Miguel Ángel de la   +2 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Concentration of Polyunsaturated Fatty Acid in Palm Oil by Urea Complexation

Equilibrium, 2018
Linoleic acid is a Poly-Unsaturated Fatty Acid (PUFA) that corresponds to Omega 6 Fatty Acid. This is the major component of vegetable oil and very important for health. As an essential fatty acid, linoleic acid has to be obtained from foods. Consumption
Dwi Ardiana Setyawardhani, margono margono, Ardi Pratama, Fermanditya Petratama   +3 more
doaj   +1 more source

Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease [PDF]

, 2014
Background: There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n−3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).
Abraham, Ananthakrishnan, Ananthakrishnan, Ananthakrishnan, Arita, Bartoli, Belluzzi, Bingham, Burdge, Chan, Charpentier, Corey, Depner, Feagan, Fritsche, Goldbohm, Goldman, Hommes, Jostins, Kaaks, Levy, Novak, Rao, Riboli, Rodriguez-Lagunas, Sakamoto, Salem, Samuelsson, Serhan, Serini, Shivananda, Tjonneland, Turner, Watanabe, Weylandt, Yaqoob   +35 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source