Results 81 to 90 of about 3,736,253 (314)

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Nature Communications
Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases.
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein   +29 more
doaj   +1 more source

Trans-Fatty Acids [PDF]

, 2016
Not all fats are suitable for high frying at temperatures of 130–180 °C. Water in fats, like in butter, evaporates at 100 °C and then starts to spatter. Excipients from the pulp of cold-pressed oils can become altered and develop an unpleasant odor or taste when heated above 150 °C.
openaire   +1 more source

Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model [PDF]

, 2001
The desaturation of [1-14C]18:3n-3 to docosahexaenoic acid (DHA; 22:6n-3) is enhanced in an essential fatty acid deficient cell line (EPC-EFAD) in comparison with the parent cell line (EPC) from carp. In the present study, the effects of DHA on lipid and
Tocher, Douglas R, Dick, James R
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Composition of essential oil and fatty acids of Centaurea pichleri ssp. pichleri

International Journal of Secondary Metabolite, 2017
In this study, the essential oil of Centaurea pichleri ssp. pichleri was obtained by hydrodistillation using a Clevenger-type apparatus. GC and GC/MS analyzes of the essential oil from Centaurea pichleri ssp.
Pelin Tastan, Tugce Fafal, Burcu Sümer Tüzün, Tuba Gönenç, Betül Demirci, Bijen Kivcak   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Desaturase Genes Expression and Fatty Acid Composition of Pleurotus ostreatus in Response to Zinc and Iron [PDF]

Journal of Cell and Molecular Research, 2018
The influence of ZnSO4, FeSO4, ZnO, and Fe2O3 at 80 µM on the expression of desaturase genes and fatty acid composition of Pleurotus ostreatus was investigated. Fatty acid was extracted by lipid extraction and methylation procedure using acidic methanol:
Kamran Safavi, Gholamreza Kavoosi, Roghayeh Siahbalaei   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Study the content of a bacterium Listeria monocytogenes of fatty acids [PDF]

مجلة التربية والعلم, 2007
The study conducted the determination of fatty acids of Listeria monocytogenes by using Gas Liquid Chromatography (GLC) after extraction and esterification of fatty acids .
Ameera Alrawi, Mayada Altaee, Sahera Hameed   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source