Results 61 to 70 of about 620,875 (297)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Quantitative genetic manipulation for nauplii size reduction of Artemia franciscana Kellogg, 1906 from Indian salinas and correlated changes in the polyunsaturated fatty acids (PUFA) profile [PDF]

, 2014
Thirteen generations of mass selection was carried out in a strain of Artemia franciscana collected from an Indian salina. The primary trait under selection was nauplii length, and the criteria of selection was small size.
Chakraborty, Kajal, Jayasankar, J, Sajesh Kumar, N K, Thomas, P C, Vijayan, K K, Vikas, P A   +5 more
core  

Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas [PDF]

, 2018
Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function.
Andrés Garrido, Ascensión, Crespo González, José Luis, Heredia Martínez, Luis G., Martínez Force, Enrique, Pérez Pérez, Maria Esther   +4 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

CHIRONOMUS PLUMOSUS LARVAE - A SUITABLE NUTRIENT FOR FRESHWATER FARMED FISH [PDF]

Poljoprivreda, 2007
Crude protein, fat, water, ash, dry matter and essential amino and fatty acids were analyzed from freshly collected Chironomus plumosus larvae in order to evaluate their suitability as a component for farmed fish diet.
I. Bogut, Elizabeta Has-Schön, Z. Adámek, Valentina Rajković, Dalida Galović   +4 more
doaj  

The chemical composition, fatty acid, amino acid profiles and mineral content of six fish species commercialized on the Wouri river coast in Cameroon [PDF]

, 2014
The chemical composition and nutritional qualities of fats and proteins of six species of fish: Herring (Clupea Harengus), Belt (Trichius Lepterus), Catfish (Arius Maculatus), Red carp (Cyprinus Carpio), Disc (Symphysadon Discus) and Mullet (Semotilus ...
Linder, Michel, Tchouanguep Mbiapo, Félicité, Tenyang, Noel, Tiencheu, Bernard, Villeneuve, Pierre, Womeni, Hilaire Macaire   +5 more
core  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Les rôles physiologiques majeurs exercés par les acides gras polyinsaturés (AGPI)

Oléagineux, Corps gras, Lipides, 2005
Polyunsaturated fatty acids (PUFAs) are essential nutrients for mammals and the human species, and belong to either of two distinct and not interconvertible series, omega 6 and omega 3.
Guesnet Philippe, Alessandri Jean-Marc, Astorg Pierre, Pifferi Fabien, Lavialle Monique   +4 more
doaj   +1 more source

Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial

Revista da Escola de Enfermagem da USP, 2015
OBJECTIVE To evaluate the efficacy of Calendula officinalis in relation to Essential Fatty Acids for the prevention and treatment of radiodermatitis. METHOD This is a randomized double-blind controlled clinical trial with 51 patients with head and neck ...
Franciane Schneider, Mitzy Tannia Reichembach Danski, Stela Adami Vayego   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source