Results 51 to 60 of about 637,805 (212)

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source

Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period

Journal of Lipid Research, 2003
Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a novel method to study the specific incorporation of dietary
Richard B. Heath, Fredrik Karpe, Ross W. Milne, Graham C. Burdge, Stephen A. Wootton, Keith N. Frayn   +5 more
doaj   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, Volume 13, Issue 31, 4 June 2026.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration

Mediators of Inflammation, 2012
Although exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions.
Cassiano Felippe Gonçalves de Albuquerque, Patrícia Burth, Mauricio Younes Ibrahim, Diogo Gomes Garcia, Patrícia Torres Bozza, Hugo Caire Castro Faria Neto, Mauro Velho Castro Faria   +6 more
doaj   +1 more source

Cell-associated nonesterified fatty acid levels and their alteration during lipolysis in the isolated mouse adipose cell

Journal of Lipid Research, 1973
A rapid and flexible method has been developed for measuring cell-associated, probably intracellular, nonesterified fatty acids (CAFA) in isolated mouse adipose cells. A variety of lipolytic agents as well as various concentrations of epinephrine elevate
Samuel W. Cushman, Jerrold J. Heindel, Bernard Jeanrenaud   +2 more
doaj   +1 more source

KCNK16 Deficiency Deteriorates Body Growth and Diet‐Independently Decreases Lipid Accumulation in Mice

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Loss of KCNK16 in mice alters β‐cell insulin secretion dynamics leading to increased pancreatic insulin content and decreased circulating IGF‐1. Furthermore, body growth and adiposity were reduced independent of dietary interventions. Despite these changes, overall glucose tolerance and insulin sensitivity remain largely preserved.
Olena Früh, Jennifer Winkler, Jana M. Jäger, Rongwan Sun, Aoxue Liu, Niklas Hegemann, Jana Grune, Atsuyo Ikeda, Andreas Diefenbach, Matthias Schäfer, Uwe Schwahn, Johann Gassenhuber, Klaus Steinmeyer, Joachim Spranger, Knut Mai, Sebastian Brachs   +15 more
wiley   +1 more source

Effects of Shade and Concentrate Supplementation on Heat Tolerance, Metabolic, and Hematological Responses of Holstein Cows in a Semi‐Arid Environment

New Zealand Journal of Agricultural Research, Volume 69, Issue 3, June 2026.
This study evaluated heat tolerance and biochemical and haematological responses of Holstein cows exposed to different environmental conditions (full sun or shade) and feeding regimens (with or without concentrate) in the semi‐arid region of Brazil. Sixteen adult cows were distributed across four treatments.
David Ramos da Rocha, Ana Elisa Custódio Montes Cândido, Aline da Silva Rocha, Stela Antas Urbano, Felipe Pontes Teixeira das Chagas, Ana Beatriz Graciano da Costa, José Fernando Bibiano Melo, Fábio Nunes Lista, Hewerthon David Reis Carneiro Rios, Deise Rejane Silva de Oliveira, Juliana Caroline Santos Santana, João Virgínio Emerenciano Neto   +11 more
wiley   +1 more source

Circulating Non-Esterified Fatty Acids as Biomarkers for Fat Content and Composition in Pigs

Animals, 2021
Circulating non-esterified fatty acids (NEFA) can reflect the composition of dietary fat or adipose tissues depending on the fasting conditions. Therefore, circulating NEFA may be valuable as biomarkers for meat quality traits, such as intramuscular fat ...
Marc Tor, Francesca Vilaró, Roger Ros-Freixedes, Javier Álvarez-Rodríguez, Lluís Bosch, Sofia Gol, Ramona N. Pena, Josep Reixach, Joan Estany   +8 more
doaj   +1 more source

Overestimation of Plasma Nonesterified Fatty Acid Concentrations in Heparinized Blood [PDF]

Circulation, 2004
To the Editor: With much interest have we read the important study on the use of glucose-insulin-potassium (GIK) in diabetic patients undergoing coronary artery bypass grafting by Lazar and coworkers.1 A potential mechanism underlying the beneficial effect of GIK administration includes metabolic modulation of (post)ischemic myocardium.
Visser, Liesbeth, Zuurbier, Coert J., van Wezel, Harry B., van der Vusse, Ger J., Hoek, Frans J.   +4 more
openaire   +2 more sources