Results 71 to 80 of about 1,040,136 (170)

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Effects of dietary long-chain polyunsaturated fatty acids on plasma amino acids and indices of protein metabolism in infants: Results from a randomized clinical trial [PDF]

, 1998
Background/Aim: Previous studies in vitro and in animals in vivo found that alpha-linolenic acid (C18:3 omega 3) may enhance oxidative damage of essential amino acids.
Burus, I., Decsi, Tamás, Koletzko, Berthold   +2 more
core   +1 more source

Methylglyoxal mildly impairs spatial memory and reduces expression of excitatory synaptic genes in the hippocampus of male mice

Physiological Reports, Volume 14, Issue 16, August 2026.
Abstract Diabetes is associated with cognitive impairment and alterations in synaptic molecules; however, the factors within the diabetic milieu that drive these central changes remain unclear. Methylglyoxal (MG), a reactive dicarbonyl and major precursor of advanced glycation end products, accumulates under hyperglycemic and metabolically compromised ...
Akane Nakao, Takumi Yokokawa, Fuminori Okazaki, Nobumasa Iwanaka, Kazuo Inoue, Tatsuya Hayashi, Tatsuro Egawa   +6 more
wiley   +1 more source

Effects of fatty acids on inflammatory markers studies in vitro and in vivo

, 2008
Inflammation involves interactions amongst many different cell types as a defense mechanism of the body. Inflammation is also involved in cardiovascular disease (CVD).
Mohd Yusof, Hayati
core   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Supplementing five-point body condition score with body fat percentage increases the sensitivity for assessing overweight status of small to medium sized dogs

Veterinary Medicine: Research and Reports, 2012
Gebin Li,1 Peter Lee,1 Nobuko Mori,1 Ichiro Yamamoto,1 Koh Kawasumi,1 Hisao Tanabe,2 Toshiro Arai11Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 2Komazawa Animal Hospital, Tokyo ...
Arai T, Tanabe H, Kawasumi K, Yamamoto I, Mori N, Lee P, Li GB   +6 more
doaj  

Effects of an Ala54Thr polymorphism in the intestinal fatty acid-binding protein on responses to dietary fat in humans

Journal of Lipid Research, 2000
A polymorphism in FABP2 that results in an alanine-to-threonine substitution at amino acid 54 of the intestinal fatty acid-binding protein (IFABP) is associated with insulin resistance in Pima Indians.
R.E. Pratley, L. Baier, D.A. Pan, A.D. Salbe, L. Storlien, E. Ravussin, C. Bogardus   +6 more
doaj   +1 more source

Micronutrients, omega-3 fatty acids and cognitive performance in Indian schoolchildren [PDF]

, 2009
In developing countries, approximately 30-40% of school-age children suffer from iodine and iron deficiencies. Poverty and consumption of monotonous diets are underlying causes of inadequate intakes of micronutrients and omega-3 fatty acids and may have ...
Eilander, J.H.C.
core  

The tissue distribution of lipoprotein lipase determines where chylomicrons bind

Journal of Lipid Research, 2015
To determine the role of LPL for binding of lipoproteins to the vascular endothelium, and for the distribution of lipids from lipoproteins, four lines of induced mutant mice were used.
Roger Savonen, Michaela Hiden, Magnus Hultin, Rudolf Zechner, Sanja Levak-Frank, Gunilla Olivecrona, Thomas Olivecrona   +6 more
doaj   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source