ABSTRACT Objective Glucagon‐receptor (GCGR) agonism reguglates bile acid (BA) metabolism and promotes weight loss in diet‐induced obese (DIO) mice. Thus, we hypothesized that BA signaling contributes to GCGR‐stimulated weight loss. Methods To test this hypothesis, we utilized BA‐binding resins (BARs; colesevelam [Colsv] and cholestyramine [Cstyr]) to ...
Teayoun Kim +9 more
wiley +1 more source
Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal: potential glucogenic role for GLP-1. [PDF]
Prolonged food deprivation increases lipid oxidation and utilization, which may contribute to the onset of the insulin resistance associated with fasting.
Crocker, Daniel E +7 more
core +1 more source
Gebin Li,1 Peter Lee,1 Nobuko Mori,1 Ichiro Yamamoto,1 Koh Kawasumi,1 Hisao Tanabe,2 Toshiro Arai11Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 2Komazawa Animal Hospital, Tokyo ...
Arai T +6 more
doaj
A polymorphism in FABP2 that results in an alanine-to-threonine substitution at amino acid 54 of the intestinal fatty acid-binding protein (IFABP) is associated with insulin resistance in Pima Indians.
R.E. Pratley +6 more
doaj +1 more source
Improved insulin sensitivity following a short-term whole body vibration intervention [PDF]
Background and Objective: Despite being recommended for reducing the risk of type 2 diabetes (T2D) the majority of the population do not partake in the advised amount of regular exercise.
Babraj, John, Hawkey, Adam
core +2 more sources
A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans [PDF]
BACKGROUND: High fructose consumption is suspected to be causally linked to the epidemics of obesity and metabolic disorders. In rodents, fructose leads to insulin resistance and ectopic lipid deposition.
Austin +44 more
core +1 more source
Impact of stressing a pen mate on physiological responses of growing pigs [PDF]
Crossbred barrows and gilts (n = 36), weighing 16.59 ± 2.1 kg, were used to test the effects of stressing a pen mate on the physiological responses of growing pigs.
Apple, Jason +3 more
core +2 more sources
Insulin decreases plasma cholesteryl ester transfer but not cholesterol esterification in healthy subjects as well as in normotriglyceridaemic patients with type 2 diabetes [PDF]
Background. Plasma cholesterol esterification (EST) and subsequent cholesteryl ester transfer (CET) from high-density lipoproteins (HDLs) towards apolipoprotein (apo) B-containing lipoproteins are key steps in HDL metabolism. Materials and methods.
Dullaart, R.P.F. (Robin) +3 more
core +3 more sources
NMR studies of membrane structure and dynamics [PDF]
Over the past decade, there has been considerable interest in the motional state of the phospholipid bilayer membrane. The motivation underlying these efforts has been the contention that the phospholipid bilayer is the basic matrix in which membrane ...
Bocian, David F., Chan, Sunney I.
core +1 more source
The tissue distribution of lipoprotein lipase determines where chylomicrons bind
To determine the role of LPL for binding of lipoproteins to the vascular endothelium, and for the distribution of lipids from lipoproteins, four lines of induced mutant mice were used.
Roger Savonen +6 more
doaj +1 more source

