Results 51 to 60 of about 183,416 (257)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Glucosinolates and Omega-3 Fatty Acids from Mustard Seeds: Phytochemistry and Pharmacology

Plants, 2022
Seeds from mustard (genera Brassica spp. and Sinapsis spp.), are known as a rich source of glucosinolates and omega-3 fatty acids. These compounds are widely known for their health benefits that include reducing inflammation and lowering the risk of ...
Gitishree Das, Ourlad Alzeus G. Tantengco, Rosa Tundis, Joyce Ann H. Robles, Monica Rosa Loizzo, Han Seung Shin, Jayanta Kumar Patra   +6 more
doaj   +1 more source

Milk Chemical Composition of Dairy Cows Fed Rations Containing Protected Omega-3 Fatty Acids and Fermented Rice Bran [PDF]

, 2013
The research was conducted to investigate the effect of ration containing protected omega-3 and fermented rice bran on chemical composition of dairy milk. The research employed 10 female PFH dairy cows of 2-4 years old with body weight 300-375 kg.
Purnomo, S. H. (S), Sudibya, S. (Sudibya)   +1 more
core  

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth [PDF]

, 2014
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation.
Arai, Hiroyuki, Arimoto, Takahide, Arita, Makoto, Fujii, Tomoyuki, Furuya, Hitomi, Isobe, Yosuke, Iwamoto, Ryo, Kang, Jing X., Kawana, Kei, Kozuma, Shiro, Masuda, Koji, Nagamatsu, Takeshi, Nagasaka, Kazunori, Oda, Katsutoshi, Osuga, Yutaka, Taguchi, Ayumi, Taketani, Yuji, Tomio, Kensuke, Wada-Hiraike, Osamu, Yamashita, Aki, Yamashita, Takahiro   +20 more
core   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Nanoemulsion-Enhanced Cardiac Delivery of Omega-3 Fatty Acids Reduces Myocardial Fibrosis and Improves Diastolic Function in a Murine HFpEF Model

Precision Nanomedicine
Omega-3 polyunsaturated fatty acids (PUFAs) exert cardiometabolic and anti-inflammatory effects, yet their clinical efficacy remains inconsistent, potentially due to limited tissue bioavailability.
Kati Frid, Yair Rokach, Orli Binyamin, Tsipora Markovitz-Patcher, Alicia I. Leikin-Frenkel, Liraz Larush, Shlomo Magdassi, Rabea Asleh, Ruth Gabizon   +8 more
doaj   +1 more source

Causal Association Between Omega-3 Fatty Acids and Risk of Breast Cancer: A Mendelian Randomization Study

Zhongliu Fangzhi Yanjiu
ObjectiveTo explore the causal relationship between Omega-3 fatty acids and the risk of breast cancer via Mendelian randomization analysis. MethodsAnalysis was conducted on data from genome-wide association studies (GWASs) on Omega-3 fatty acids and ...
Jiaqi WANG, Wei TANG, Xiao HUANG, Deyuan FU   +3 more
doaj   +1 more source

Proximate composition and fatty acid and cholesterol content of 22 species of northwest Atlantic finfish [PDF]

, 1989
The moisture, fat, ash, fatty acid profile, and cholesterol content are reported for cooked and raw fillets from 22 species of finfish found in the Northwest Atlantic. All but nine species had 1%or less fat.
Krzynowek, Judith, Maney, Richard S., Murphy, Jenny, Panunzio, Laurie J.   +3 more
core  

The efficacy of fish oil supplements in the treatment of depression: food for thought. [PDF]

, 2016
A recent meta-analysis and meta-regression of 13 randomized clinical trials by Mocking et al.1 concluded that supplementation with omega-3 fatty acids, found naturally in fatty fish, has a beneficial effect in patients with major depressive disorder (MDD)
Appleton, Katherine, Bastiaansen, J.A., Munafò, M.R., Oldehinkel, A.J.   +3 more
core   +3 more sources