Results 1 to 10 of about 6,127,399 (262)

Artesunate improves DDC-induced cholestatic liver fibrosis through PI3K/Akt/mTOR signaling pathway in mice

陆军军医大学学报, 2023
Objective To explore the effect and molecular mechanism of artesunate (ART) on cholestatic liver fibrosis induced by 3, 5-diethoxycarbonyl-1, 4-dihydro-2, 4, 6-collidine (DDC).
TANG Wan, ZHAO Nan, ZHANG Xiaoxun, CHAI Jin   +3 more
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Screening and validation of Hub genes in bile acid-induced hepatocyte response based on transcriptome sequencing

陆军军医大学学报, 2023
Objective To screen and verify the Hub genes involved in conjugated bile acid-induced hepatocyte metabolism through transcriptome sequencing analysis. Methods Primary mouse hepatocytes were treated with taurocholic acid (TCA), and the gene expression of ...
ZHANG Mengni, ZHANG Mengni, ZHANG Xiaoxun, OUYANG Jiafeng, CHAI Jin   +4 more
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Carrier-free curcumin nanoassemblies for enhancing therapy effects in inflammation related disease

Materials & Design, 2022
Hyperinflammation can lead to tissue injury, organ failure, and even fatalities by overproducing proinflammatory cytokines. The long-term safety and outstanding anti-inflammatory ability of natural products have attracted much attention, but the low ...
Liangjun Zhang, Haihan Xia, Song Du, Nan Zhao, Xiaoxun Zhang, Qiong Pan, Senlin Xu, Zhicheng He, Zeng Yi, Jin Chai   +9 more
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Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases

Frontiers in Pharmacology, 2022
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng, Qianyu Tang, Fan Xiao, Nian Fu, Nian Fu   +4 more
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Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation

Materials & Design, 2023
Acute liver injury (ALI) is one of the most important causes of liver failure, and there are no FDA-approved drugs that could therapy late-stage ALI. It has been shown in this study that HA-PEI, a molecule formed by covalently combining HA and PEI, can ...
Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai   +10 more
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Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis

Nature Communications, 2023
The aetiology of primary biliary cholangitis (PBC) remains unclear. Here, the authors find that the numbers of DUOX2 + ACE2 + small cholangiocytes in human and mouse livers are inversely associated with disease severity, and present data indicating that ...
Xi Li, Yan Li, Jintao Xiao, Huiwen Wang, Yan Guo, Xiuru Mao, Pan Shi, Yanliang Hou, Xiaoxun Zhang, Nan Zhao, Minghua Zheng, Yonghong He, Jingjing Ding, Ya Tan, Min Liao, Ling Li, Ying Peng, Xuan Li, Qiong Pan, Qiaoling Xie, Qiao Li, Jianwei Li, Ying Li, Zhe Chen, Yongxiu Huang, David N. Assis, Shi-Ying Cai, James L. Boyer, Xuequan Huang, Can-E Tang, Xiaowei Liu, Shifang Peng, Jin Chai   +32 more
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In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease: Mechanism and pharmacological interventions

Liver Research, 2023
Non-alcoholic fatty liver disease (NAFLD) is characterized by the abnormal buildup of lipids in the liver tissue. Non-alcoholic fatty liver (NAFL) may progress to non-alcoholic steatohepatitis.
Zhixian Zhu, Xiaoxun Zhang, Qiong Pan, Liangjun Zhang, Jin Chai   +4 more
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Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study

Frontiers in Medicine, 2022
Background:Non-alcoholic fatty liver disease (NAFLD) is a global health problem affecting more than a quarter of the entire adult population. Both monocytes and high-density lipoprotein cholesterol (HDL-C) were found to participate in the progression of ...
Liping Wang, Liping Wang, Jinzhong Dong, Miao Xu, Li Li, Naibin Yang, Naibin Yang, Guoqing Qian, Guoqing Qian   +8 more
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Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in HumansSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: OATP1B3/SLCO1B3 is a human liver-specific transporter for the clearance of endogenous compounds (eg, bile acid [BA]) and xenobiotics.
Qiong Pan, Guanyu Zhu, Ziqian Xu, Jinfei Zhu, Jiafeng Ouyang, Yao Tong, Nan Zhao, Xiaoxun Zhang, Ying Cheng, Liangjun Zhang, Ya Tan, Jianwei Li, Chengcheng Zhang, Wensheng Chen, Shi-Ying Cai, James L. Boyer, Jin Chai   +16 more
doaj   +1 more source

Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases

Frontiers in Pharmacology, 2022
Thyroid hormone/thyroid hormone receptor (TH/TR) axis is characterized by TH with the assistance of plasma membrane transporters to combine with TR and mediate biological activities.
Qianyu Tang, Min Zeng, Linxi Chen, Nian Fu, Nian Fu   +4 more
doaj   +1 more source