Results 101 to 110 of about 394,213 (300)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A novel fault line selection method based on empirical mode decomposition and differential spectrum

Gong-kuang zidonghua, 2013
The paper proposed a novel single-phase grounding fault line selection method of small current grounding system based on EMD and differential spectrum.
ZHENG Chen, WANG Xiao-wei, LIU Ya-juan, TIAN Shu   +3 more
doaj  

Fault line selection method for resonant grounding systems based on DTW-Hilbert and improved K-means

Gong-kuang zidonghua
Due to the influence of factors such as arc suppression coils, transition resistance, and environmental noise, the fault signal characteristics in resonant grounding systems are weak.
ZHANG Zhaoxi, ZHANG Hongle, HUANG Yanfa, CHEN Xingxiang, JIA Haicheng, YUAN Pengsheng   +5 more
doaj   +1 more source

A Fault Line Selection Method for DC Distribution Network Using Multiple Observers

Energies, 2019
This paper proposes a method of fault line selection for a DC distribution network. Firstly, the 1-mode current is calculated using the measured currents of the positive and the negative line.
Xipeng Zhang, Nengling Tai, Pan Wu, Xiaodong Zheng, Wentao Huang   +4 more
doaj   +1 more source

AFTI/F-16 digital flight control system experience [PDF]

, 1984
The Advanced Flighter Technology Integration (AFTI) F-16 program is investigating the integration of emerging technologies into an advanced fighter aircraft.
Mackall, D. A.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Injection Current Distribution Characteristics Identification Based Distribution-Level Fault Line Selection

Zhongguo dianli
Addressing the challenges posed by the subtle characteristics of single-phase grounding faults in resonant grounding systems, which lead to decreased sensitivity and reliability in fault line selection methods reliant on these characteristics, an ...
Xiaowei WANG, Yang YUE, Liang GUO, Xue WANG, Yizhao WANG, Zhihua ZHANG, Fengfeng YANG   +6 more
doaj   +1 more source

Ground Fault Line Selection with Improved Residual Flow Incremental Method

TELKOMNIKA Indonesian Journal of Electrical Engineering, 2013
According to the shortcoming of single-phase ground fault line selection method in the resonant grounded system such as the uncertainty of its device by fast compensation with the automatic compensation equipment, an arc suppression and residual flow incremental method is proposed to effectively choose the earth fault line.
Wenhong Li, Tingqiang Guan, Xueguang Qi, Gonghua Wang   +3 more
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Fault line selection of coal mine power grid based on dual-tree complex wavelet

Gong-kuang zidonghua, 2014
The paper proceeded from actual conditions of coal mine power grid, discussed in allusion to four cases of three-phase TA, two-phase TA, single-phase TA and zero-sequence TA.
HUANG Zhi, REN Qihong, YU Qiang
doaj   +1 more source