Results 51 to 60 of about 130,257 (305)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A new fault tolerant control scheme for non‐linear systems by T‐S fuzzy model approach

IET Control Theory & Applications, 2021
This paper is concerned with the problem of fault tolerant control for non‐linear systems with sensor faults based on the T‐S fuzzy model approach. First, a fault estimation (FE) observer with L∞ technique is designed to estimate the fault.
Yue Wu, Yang Wang, Tieshan Li, Zhixin Yang   +3 more
doaj   +1 more source

Fault estimation and fault-tolerant control for discrete-time dynamic systems [PDF]

, 2015
In this paper, a novel discrete-time estimator is proposed, which is employed for simultaneous estimation of system states, and actuator/sensor faults in a discrete-time dynamic system.
Gao, Zhiwei
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Adaptive Integral-Type Terminal Sliding Mode Fault Tolerant Control for Spacecraft Attitude Tracking

IEEE Access, 2019
In this paper, the attitude tracking control for a spacecraft system based on a novel adaptive integral-type terminal sliding mode fault-tolerant control strategy is investigated.
Zhao Wang, Qi Li, Shurong Li
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Review of Fault-Tolerant Control Methods for Suspension Systems: From Road Vehicles to Maglev Trains

Mathematics
Road vehicles and maglev trains have garnered significant attention, with their suspension systems being crucial for safe and stable performance. However, these systems can be compromised by faults such as sensor and actuator failures, posing risks to ...
Fei Ni, Yifan Luo, Junqi Xu, Dachuan Liu, Yougang Sun, Wen Ji   +5 more
doaj   +1 more source

Fault tolerant model predictive control of open channels [PDF]

, 2014
Automated control of water systems (irrigation canals, navigation canals, rivers etc.) relies on the measured data. The control action is calculated, in case of feedback controller, directly from the on-line measured data.
Blesa Izquierdo, Joaquim, Chuquet, Karine, Duviella, Eric, Horváth, Klaudia   +3 more
core  

Active actuator fault-tolerant control of a wind turbine benchmark model [PDF]

, 2014
This paper describes the design of an active fault-tolerant control scheme that is applied to the actuator of a wind turbine benchmark. The methodology is based on adaptive filters obtained via the nonlinear geometric approach, which allows to obtain ...
Baldi, Blanke, Bonfè, Castaldi, Chen, De Persis, Ding, Dodson, Edwards, Edwards, Edwards, Edwards, Ioannou, Isermann, Johnson, Mahmoud, Mattone, Odgaard, Odgaard, Odgaard, Odgaard, Rotondo, Sami, Simani, Simani, Simani, Zhang   +26 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source