Regulation of immune responses by the neonatal Fc receptor and its therapeutic implications [PDF]
Frontiers in Immunology, 2015 As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation.
Timo eRath +4 more
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FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features [PDF]
Diagnostics, 2023 Background: Endometrial cancer (EC) has robust molecular diagnostic evidence that correlates well with prognosis. In various types of cancers, FcRn has been identified as an early marker for prognosis.
Dae Hyun Song +5 more
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Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn. [PDF]
PLoS ONE, 2012 The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation.
Ana Paula Catunda Lemos +9 more
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Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor [PDF]
Nature CommunicationsHuman astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz +5 more
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From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases [PDF]
Frontiers in ImmunologyThe neonatal Fragment Crystallizable receptor (FcRn) plays a central role in maintaining immunoglobulin (Ig) G homeostasis by protecting IgG from lysosomal degradation and regulating its transcytosis.
Chu Wei Yang +10 more
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The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]
PLoS PathogensThe neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na +4 more
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Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy [PDF]
, 2017 At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life.
Christopher R Wilcox +2 more
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Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells. [PDF]
PLoS PathogensClassical human astroviruses (HAstV) are a global cause of viral gastroenteritis, particularly in children and immunocompromised individuals. Despite their clinical significance, the biology of HAstV remains poorly understood.
Catalina Aguilera-Flores +8 more
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Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation [PDF]
Communications BiologyIgGs have become successful drug scaffolds by combining specific target binding with the ability to induce cellular cytotoxicity. Furthermore, IgGs possess unusually long half-lives in the blood (2-3 weeks).
Esben Trabjerg +5 more
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The Role of FcRn in Antigen Presentation [PDF]
, 2014 Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to
Kristi Baker +3 more
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