Megalin Orchestrates FcRn Endocytosis and Trafficking
Cells, 2022 The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is the
Eileen Dahlke +4 more
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Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor [PDF]
Nature CommunicationsHuman astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz +5 more
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Impact of Neonatal Fc Receptor on Transferrin Receptor Antibody Fusion Protein Pharmacokinetics [PDF]
PharmaceuticsBackground: Transferrin receptor-targeting monoclonal antibodies (TfRMAbs) enhance brain drug delivery by facilitating TfR-mediated transcytosis across the blood–brain barrier (BBB).
Adenike Oyegbesan +3 more
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Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn. [PDF]
PLoS ONE, 2012 The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation.
Ana Paula Catunda Lemos +9 more
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Cell surface dynamics and cellular distribution of endogenous FcRn. [PDF]
PLoS ONE, 2017 A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH.
Lena D'Hooghe +3 more
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From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases [PDF]
Frontiers in ImmunologyThe neonatal Fragment Crystallizable receptor (FcRn) plays a central role in maintaining immunoglobulin (Ig) G homeostasis by protecting IgG from lysosomal degradation and regulating its transcytosis.
Chu Wei Yang +10 more
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The neonatal Fc receptor expression during macrophage differentiation is related to autophagy
Frontiers in Immunology, 2022 The neonatal Fc receptor (FcRn) plays a central role in recycling and biodistributing immunoglobulin G. FcRn is also involved in many physiological immune functions as well as pathological immune responses in cancer or autoimmune diseases.
Juliette Lamamy +8 more
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FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features
Diagnostics, 2023 Background: Endometrial cancer (EC) has robust molecular diagnostic evidence that correlates well with prognosis. In various types of cancers, FcRn has been identified as an early marker for prognosis.
Dae Hyun Song +5 more
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Frontiers in Microbiology, 2020 Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon ...
Shaoju Qian +16 more
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THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9
Вопросы вирусологии, 2019 The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva +4 more
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