Results 1 to 10 of about 8,114 (214)

Megalin Orchestrates FcRn Endocytosis and Trafficking [PDF]

Cells, 2022
The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is the
Eileen Dahlke, Yaman Anan, Lea Maximiliane Klie, Ariane Elisabeth Hartkopf, Franziska Theilig   +4 more
doaj   +4 more sources

Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor [PDF]

Nature Communications
Human astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAstV, however the molecular basis for the FcRn-HAstV interaction remained unclear ...
Adam Lentz, Sarah Lanning, Khurshid R. Iranpur, Lena Ricemeyer, Carlos F. Arias, Rebecca M. DuBois   +5 more
doaj   +2 more sources

Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines [PDF]

Vaccines, 2022
As a developmental toxicant, Zika virus (ZIKV) attacks both the growing nervous system, causing congenital Zika syndrome, and the placenta, resulting in pathological changes and associated adverse fetal outcomes.
Yanqun Xu, Yong He, Sanaz Momben-Abolfath, Devin Vertrees, Xiaohong Li, Malgorzata G. Norton, Evi Budo Struble   +6 more
doaj   +2 more sources

From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases [PDF]

Frontiers in Immunology
The neonatal Fragment Crystallizable receptor (FcRn) plays a central role in maintaining immunoglobulin (Ig) G homeostasis by protecting IgG from lysosomal degradation and regulating its transcytosis.
Chu Wei Yang, Ting Xia, Qing Tan, Qing Tan, Li Gang Jie, Ai Ju Lou, Xiao Xiao Li, Maierhaba Maitiyaer, Wen Hui Huang, Yu Zheng, Shui Lian Yu   +10 more
doaj   +2 more sources

The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [PDF]

PLoS Pathogens
The neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses.
Lei Na, Yang Zheng, Jian-Bo Yang, Hao-Lin Bao, Yan-Dong Tang   +4 more
doaj   +2 more sources

Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells. [PDF]

PLoS Pathogens
Classical human astroviruses (HAstV) are a global cause of viral gastroenteritis, particularly in children and immunocompromised individuals. Despite their clinical significance, the biology of HAstV remains poorly understood.
Catalina Aguilera-Flores, María Del Pilar Valencia-Morales, Tomás López, Joaquín Moreno-Contreras, Adam Lentz, Marco A Espinoza, Rebecca M DuBois, Susana López, Carlos F Arias   +8 more
doaj   +2 more sources

Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation [PDF]

Communications Biology
IgGs have become successful drug scaffolds by combining specific target binding with the ability to induce cellular cytotoxicity. Furthermore, IgGs possess unusually long half-lives in the blood (2-3 weeks).
Esben Trabjerg, Jeannette Nilsen, Torleif Tollefsrud Gjølberg, Jan Terje Andersen, Alexander Leitner, Kasper D. Rand   +5 more
doaj   +2 more sources

Does a Polycistronic 2A Design Enable Functional FcRn Production for Antibody Pharmacokinetic Studies? [PDF]

Pharmaceutics
Nesmeyanova VS, Ushkalenko ND, Olkin SE, Kosenko MN, Rukhlova EA, Susloparov IM, Shcherbakov DN.   +6 more
europepmc   +3 more sources

Pharmacovigilance analysis of FcRn antagonists in the treatment of myasthenia gravis: A disproportionality analysis based on the FAERS database. [PDF]

Hum Vaccin Immunother
Liu B, Zhang W, Chen Y, Han A, Chen D.
europepmc   +2 more sources

Case Report: KLHL11 encephalitis in a female patient with dual primary malignancies of breast and lung cancer: response to FcRn inhibitor therapy. [PDF]

Front Immunol
Li Y, Xing H, Cao Z, Cui P, Zhao L.
europepmc   +3 more sources