Results 21 to 30 of about 6,140 (133)

Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. [PDF]

PLoS ONE, 2017
Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and
Bence Szikora, László Hiripi, Balázs Bender, Imre Kacskovics, Attila Iliás   +4 more
doaj   +1 more source

Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang, Wang Chonglong, Liu Zhengzhu, Xu Jingen, Fu Weixuan, Wang Wenwen, Ding Xiangdong, Liu Jianfeng, Zhang Qin   +8 more
doaj   +1 more source

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

mAbs, 2021
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin.
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen   +7 more
doaj   +1 more source

Fully human monoclonal antibody inhibitors of the neonatal Fc receptor (FcRn) reduce circulating IgG in nonhuman primates

Frontiers in Immunology, 2015
The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal ...
Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor   +12 more
doaj   +1 more source

Human IgE does not bind to human FcRn

Scientific Reports, 2022
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson   +6 more
doaj   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon   +25 more
doaj   +1 more source

EffCRN: An Efficient Convolutional Recurrent Network for High-Performance Speech Enhancement [PDF]

arXiv, 2023
Fully convolutional recurrent neural networks (FCRNs) have shown state-of-the-art performance in single-channel speech enhancement. However, the number of parameters and the FLOPs/second of the original FCRN are restrictively high. A further important class of efficient networks is the CRUSE topology, serving as reference in our work.
arxiv  

IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring

Clinical and Molecular Allergy, 2010
Background The mechanism(s) responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma, we demonstrated previously that resistance to allergic airway disease transmitted
Rafti Ektor, Thrall Roger S, Matson Adam P, Lingenheld Elizabeth G, Puddington Lynn   +4 more
doaj   +1 more source

AEC in a NetShell: On Target and Topology Choices for FCRN Acoustic Echo Cancellation [PDF]

arXiv, 2021
Acoustic echo cancellation (AEC) algorithms have a long-term steady role in signal processing, with approaches improving the performance of applications such as automotive hands-free systems, smart home and loudspeaker devices, or web conference systems.
arxiv  

Deep Residual Echo Suppression and Noise Reduction: A Multi-Input FCRN Approach in a Hybrid Speech Enhancement System [PDF]

arXiv, 2021
Deep neural network (DNN)-based approaches to acoustic echo cancellation (AEC) and hybrid speech enhancement systems have gained increasing attention recently, introducing significant performance improvements to this research field. Using the fully convolutional recurrent network (FCRN) architecture that is among state of the art topologies for noise ...
arxiv