Results 31 to 40 of about 10,163 (201)

FcRn inhibitors: a novel option for the treatment of myasthenia gravis

Neural Regeneration Research, 2023
Myasthenia gravis is an acquired, humoral immunity-mediated autoimmune disease characterized by the production of autoantibodies that impair synaptic transmission at the neuromuscular junction. The intervention-mediated clearance of immunoglobulin G (IgG)
Li-na Zhu, Haiyan Hou, Sai-hao Wang, Shuang Zhang, Ge-Ge Wang, Zixu Guo, Jun Wu   +6 more
semanticscholar   +1 more source

FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues

Biomolecules, 2018
Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evaluated
Tommy Li, Joseph P. Balthasar
doaj   +1 more source

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, 2020
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler   +3 more
doaj   +1 more source

Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. [PDF]

PLoS ONE, 2017
Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and
Bence Szikora, László Hiripi, Balázs Bender, Imre Kacskovics, Attila Iliás   +4 more
doaj   +1 more source

Efeito do treinamento muscular resistido excêntrico em pacientes hemiparéticos crônicos após acidente vascular encefálico: uma revisão sistemática

Revista Brasileira de Prescrição e Fisiologia do Exercício, 2023
Várias intervenções têm sido propostas com a finalidade de atenuar os prejuízos motores decorrentes do Acidente Vascular Encefálico (AVE), incluindo os exercícios resistidos, entretanto, é incerto qual tipo de contração priorizar para esta população.
Liliane Araújo Guimarães, Lilian Araújo Guimarães, Fábio Firmino de Albuquerque Gurgel, Moisés Costa do Couto   +3 more
doaj  

Proof-of-concept and Randomized, Placebo-controlled Trials of an FcRn Inhibitor, Batoclimab, for Thyroid Eye Disease

Journal of Clinical Endocrinology and Metabolism, 2023
Context Inhibition of the neonatal fragment crystallizable receptor (FcRn) reduces pathogenic thyrotropin receptor antibodies (TSH-R-Ab) that drive pathology in thyroid eye disease (TED).
G. Kahaly, P. Dolman, Jan Wolf, B. Giers, H. Elflein, A. P. Jain, A. Srinivasan, L. Hadjiiski, David R. Jordan, E. A. Bradley, M. Stan, A. Eckstein, Susanne Pitz, C. Vorländer, S. Wester, J. Nguyen, Nancy Tucker, M. Sales-Sanz, S. Feldon, C. Nelson, I. Hardy, Maravillas Abia-Serrano, P. Tedeschi, J. Janes, Jing Xu, Peter Vue, W. Macias, Raymond S. Douglas   +27 more
semanticscholar   +1 more source

Efgartigimod beyond myasthenia gravis: the role of FcRn-targeting therapies in stiff-person syndrome

Journal of Neurology, 2023
Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder characterized by high titers of antibodies against glutamic acid decarboxylase (GAD) causing impaired GABAergic inhibitory neurotransmission.
Vincenzo Di Stefano, P. Alonge, N. Rini, Massimiliano Militello, A. Lupica, Angelo Torrente, F. Brighina   +6 more
semanticscholar   +1 more source

Targeting FcRn to Generate Antibody-Based Therapeutics [PDF]

Trends in Pharmacological Sciences, 2018
The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen into antigen loading compartments in specialized antigen-presenting cells.
Ward, E. Sally, Ober, Raimund J.
openaire   +3 more sources

Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang, Wang Chonglong, Liu Zhengzhu, Xu Jingen, Fu Weixuan, Wang Wenwen, Ding Xiangdong, Liu Jianfeng, Zhang Qin   +8 more
doaj   +1 more source

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

mAbs, 2021
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin.
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen   +7 more
doaj   +1 more source