Results 31 to 40 of about 8,114 (214)

THE ROLE OF THE NEONATAL FC RECEPTOR IN THE UNCOATING OF ECHOVIRUSES AND COXSACKIEVIRUS A9

Вопросы вирусологии, 2019
The aim of this study was to determine the role of the human neonatal receptor for the Fc fragment of IgG (hFcRn) as a common uncoating cellular receptor for echoviruses and coxsackievirus A9 during infection of human rhabdomyosarcoma (RD) cells ...
P. S. Usoltseva, A. V. Alimov, A. V. Rezaykin, A. G. Sergeev, A. V. Novoselov   +4 more
doaj   +1 more source

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, 2020
The neonatal Fc receptor (FcRn) is a key membrane protein that plays an integral role in serum immunoglobulin (IgG) recycling, which extends the half-life of antibody.
Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler   +3 more
doaj   +1 more source

FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues

Biomolecules, 2018
Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evaluated
Tommy Li, Joseph P. Balthasar
doaj   +1 more source

Efeito do treinamento muscular resistido excêntrico em pacientes hemiparéticos crônicos após acidente vascular encefálico: uma revisão sistemática

Revista Brasileira de Prescrição e Fisiologia do Exercício, 2023
Várias intervenções têm sido propostas com a finalidade de atenuar os prejuízos motores decorrentes do Acidente Vascular Encefálico (AVE), incluindo os exercícios resistidos, entretanto, é incerto qual tipo de contração priorizar para esta população.
Liliane Araújo Guimarães, Lilian Araújo Guimarães, Fábio Firmino de Albuquerque Gurgel, Moisés Costa do Couto   +3 more
doaj  

Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes. [PDF]

PLoS ONE, 2017
Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with rabbit and
Bence Szikora, László Hiripi, Balázs Bender, Imre Kacskovics, Attila Iliás   +4 more
doaj   +1 more source

IgG Fab Glycans Hinder FcRn-Mediated Placental Transport

The Journal of Immunology, 2023
Abstract Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated with malignant and autoimmune conditions, exemplified by rheumatoid arthritis and highly Fab-glycosylated (∼90%) anti-citrullinated protein Abs (ACPAs). Important properties
Mikhail Volkov, Maximilian Brinkhaus, Karin A van Schie, Albert Bondt, Theresa Kissel, Elvera J van der Kooi, Arthur E H Bentlage, Carolien A M Koeleman, Steven W de Taeye, Ninotska I Derksen, Radboud J E M Dolhain, Ute Braig-Scherer, Tom W J Huizinga, Manfred Wuhrer, René E M Toes, Gestur Vidarsson, Diane van der Woude   +16 more
openaire   +6 more sources

The Neonatal Fc Receptor (FcRn): A Misnomer? [PDF]

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids. Although IgG alone can directly protect the body from infection through the activities of its antigen binding region, the majority of IgG immune functions are mediated via proteins
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
openaire   +5 more sources

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

mAbs, 2021
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin.
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen   +7 more
doaj   +1 more source

FcRn inhibitors for myasthenia gravis. [PDF]

Cochrane Database Syst Rev
White LM, Clay FJ, Forbes AM, Keh RYS, Lilleker JB, Spillane J, Storms K, Dodd KC, Sussman J.   +8 more
europepmc   +3 more sources

Targeting FcRn to Generate Antibody-Based Therapeutics [PDF]

Trends in Pharmacological Sciences, 2018
The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen into antigen loading compartments in specialized antigen-presenting cells.
Ward, E. Sally, Ober, Raimund J.
openaire   +3 more sources