Results 31 to 40 of about 14,752 (202)

The Chicken Yolk Sac IgY Receptor, a Mammalian Mannose Receptor Family Member, Transcytoses IgY across Polarized Epithelial Cells [PDF]

, 2008
In mammals the transfer of passive immunity from mother to young is mediated by the MHC-related receptor FcRn, which transports maternal IgG across epithelial cell barriers.
Boskovic J., Burmeister W. P., Chaudhury C., Claypool S. M., Cutting J. A., Dawes C., Devin B. Tesar, East L., Ellinger I., Evelyn J. Cheung, Ghetie V., Keith Mostov, Kim J., Koltun M., Kowalczyk K., Larkin J. M., Leach J. L., Lencer W. I., Linden C. D., Martin W. L., Martin W. L., Mayer B., Mayer B., McCarthy K. M., McCarthy K. M., Ober R. J., Ober R. J., Ou S. K., Pamela J. Bjorkman, Praetor A., Rivera-Calzada A., Simister N. E., Simister N. E., Spiekermann G. M., Tesar D. B., Tressler R. L., Ward E. S., West A. P., Western A. H., Wu Z., Yoshida M., Zhu X.   +41 more
core   +2 more sources

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

mAbs, 2021
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin.
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen, Jan Terje Andersen   +7 more
doaj   +1 more source

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]

, 2019
Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang, Fang-Hoover, June, Freed, Daniel C, Fu, Tong-Ming, Li, Fengsheng, Pereira, Lenore, Petitt, Matthew, Tabata, Takako, Wang, Dai   +8 more
core   +1 more source

The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity [PDF]

, 2012
The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense.
Blumberg, Richard Steven, Frank, Scott Randy, Goldenring, James R., Hamman, Wendy, Hansen, Steen Henning, Lapierre, Lynne A., Lencer, Wayne Isaac, Massol, Ramiro, Tzaban, Salit, Yen, Elizabeth Hechavarria   +9 more
core   +1 more source

IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring

Clinical and Molecular Allergy, 2010
Background The mechanism(s) responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma, we demonstrated previously that resistance to allergic airway disease transmitted
Rafti Ektor, Thrall Roger S, Matson Adam P, Lingenheld Elizabeth G, Puddington Lynn   +4 more
doaj   +1 more source

Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang, Wang Chonglong, Liu Zhengzhu, Xu Jingen, Fu Weixuan, Wang Wenwen, Ding Xiangdong, Liu Jianfeng, Zhang Qin   +8 more
doaj   +1 more source

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]

, 2014
There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P., Stavenhagen, Jeffrey B., Teeling, Jessica L.   +2 more
core   +3 more sources

Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.

PLoS ONE, 2013
FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the ...
Sudhasri Mohanty, Jonghan Kim, Latha P Ganesan, Gary S Phillips, John M Robinson, Clark L Anderson   +5 more
doaj   +1 more source

Fully human monoclonal antibody inhibitors of the neonatal Fc receptor (FcRn) reduce circulating IgG in nonhuman primates

Frontiers in Immunology, 2015
The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal ...
Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor   +12 more
doaj   +1 more source

Human IgE does not bind to human FcRn

Scientific Reports, 2022
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens.
Maximilian Brinkhaus, Elvera J. van der Kooi, Arthur E. H. Bentlage, Pleuni Ooijevaar-de Heer, Ninotska I. L. Derksen, Theo Rispens, Gestur Vidarsson   +6 more
doaj   +1 more source