Results 41 to 50 of about 10,163 (201)
An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission
Nature Communications, 2023 SARS-CoV-2 is primarily transmitted through droplets and airborne aerosols, and in order to prevent infection and reduce viral spread vaccines should elicit protective immunity in the airways.
Weizhong Li +11 more
semanticscholar +1 more source
Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies [PDF]
Journal of Biological Chemistry, 2014 Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wide range of molecules such as fatty acids, metabolites, hormones, and toxins. In addition, it binds a variety of drugs. Its role as distributor is supported by its extraordinary serum half-life of 3 weeks.
Sand, Kine Marita Knudsen +10 more
openaire +4 more sources
mAbs, 2023 The blood-brain barrier (BBB) largely excludes antibodies from entering the central nervous system, thus limiting the potential of therapeutic antibodies to treat conditions such as neurodegenerative diseases and neuro-psychiatric disorders.
J. Tien +13 more
semanticscholar +1 more source
Theranostics, 2023 Rationale: The passage of antibodies through the blood-brain barrier (BBB) and the blood-tumoral barrier (BTB) is determinant not only to increase the immune checkpoint inhibitors efficacy but also to monitor prognostic and predictive biomarkers such as ...
Céline Chevaleyre +11 more
semanticscholar +1 more source
Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.
PLoS ONE, 2013 FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the ...
Sudhasri Mohanty +5 more
doaj +1 more source
Therapeutic Plasma Exchange Versus FcRn Inhibition in Autoimmune Disease.
Transfusion Medicine Reviews, 2023 Therapeutic plasma exchange (TPE or PLEX) is used in a broad range of autoimmune diseases, with the goal of removing autoantibodies from the circulation.
P. Mina-Osorio, Minh‐Ha Tran, A. Habib
semanticscholar +1 more source
FcRn expression in cancer: Mechanistic basis and therapeutic opportunities
Journal of Controlled Release, 2021 There is an urgent need to identify new cellular targets to expand the repertoire, potency and safety of cancer therapeutics. Neonatal Fc Receptor (FcRn)-driven cellular recycling plays a predominant role in the prolonged serum half-life of human serum albumin (HSA) and immunoglobulin G (IgG) exploited in long-acting cancer drug designs.
Rudnik-Jansen, Imke, Howard, Ken
openaire +3 more sources
Frontiers in Immunology, 2015 The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal ...
Andrew E Nixon +12 more
doaj +1 more source
European Journal of Pharmaceutical Sciences, 2023 Biologics are a fast-growing therapeutic class, with intertwined pharmacokinetics and pharmacodynamics, affected by the abundance and function of the FcRn receptor.
J. Barber +11 more
semanticscholar +1 more source
Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain
Brain, behavior, and immunityPreclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of ...
Nathan T. Fiore +5 more
semanticscholar +1 more source