Results 41 to 50 of about 8,114 (214)

Tissues Expression, Polymorphisms Identification of FcRn Gene and Its Relationship with Serum Classical Swine Fever Virus Antibody Level in Pigs [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization.
Liu Yang, Wang Chonglong, Liu Zhengzhu, Xu Jingen, Fu Weixuan, Wang Wenwen, Ding Xiangdong, Liu Jianfeng, Zhang Qin   +8 more
doaj   +1 more source

Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies [PDF]

Journal of Biological Chemistry, 2014
Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wide range of molecules such as fatty acids, metabolites, hormones, and toxins. In addition, it binds a variety of drugs. Its role as distributor is supported by its extraordinary serum half-life of 3 weeks.
Sand, Kine Marita Knudsen, Dalhus, Bjørn, Christianson, Gregory J., Bern, Malin C., Foss, Stian, Cameron, Jason, Sleep, Darrell, Bjørås, Magnar, Roopenian, Derry C, Sandlie, Inger, Andersen, Jan Terje   +10 more
openaire   +4 more sources

FcRn-Inhibitor Efgartigimod zur subkutanen Injektion zugelassen

InFo Neurologie + Psychiatrie
Matthias Herrmann
openalex   +2 more sources

FcRn expression in cancer: Mechanistic basis and therapeutic opportunities

Journal of Controlled Release, 2021
There is an urgent need to identify new cellular targets to expand the repertoire, potency and safety of cancer therapeutics. Neonatal Fc Receptor (FcRn)-driven cellular recycling plays a predominant role in the prolonged serum half-life of human serum albumin (HSA) and immunoglobulin G (IgG) exploited in long-acting cancer drug designs.
Rudnik-Jansen, Imke, Howard, Ken
openaire   +3 more sources

Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.

PLoS ONE, 2013
FcRn, a non-classical MHCI molecule, transports IgG from mother to young and regulates the rate of IgG degradation throughout life. Brambell proposed a mechanism that unified these two functions, saying that IgG was pinocytosed nonspecifically by the ...
Sudhasri Mohanty, Jonghan Kim, Latha P Ganesan, Gary S Phillips, John M Robinson, Clark L Anderson   +5 more
doaj   +1 more source

Fully human monoclonal antibody inhibitors of the neonatal Fc receptor (FcRn) reduce circulating IgG in nonhuman primates

Frontiers in Immunology, 2015
The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal ...
Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor   +12 more
doaj   +1 more source

FcRn, a critical regulator of antibody pharmacokinetics

Folia Pharmacologica Japonica, 2010
腫瘍や自己免疫疾患等の治療を目的とした分子標的薬として，抗体医薬品の研究開発が国内外で活発に行われている．抗体医薬品の特徴は標的分子に高い親和性をもって極めて特異的に結合することであるが，他のバイオ医薬品と比較して血中半減期が長いことも特筆すべき点である．ペプチドあるいはタンパク質を医薬品として応用する場合には血中半減期が実用化のためのハードルとなることが少なくない．しかし，多くの抗体医薬品は，生体内IgGの分解抑制に関わるneonatal Fc receptor（FcRn）を介したリサイクリング機構を利用することができるため，数日～数週間という長い血中半減期を有している．FcRnは齧歯類の新生児小腸に高発現し，乳汁に含まれる母親由来IgGの吸収に関与する受容体として同定された．その後の研究により ...
Akiko, Ishii-Watabe, Takuo, Suzuki, Minoru, Tada, Toru, Kawanishi, Teruhide, Yamaguchi, Nana, Kawasaki   +5 more
openaire   +3 more sources

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

Frontiers in Immunology, 2018
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth.
Diana Cadena Castaneda, Diana Cadena Castaneda, Christine Dhommée, Christine Dhommée, Thomas Baranek, Thomas Baranek, Emilie Dalloneau, Emilie Dalloneau, Laurie Lajoie, Laurie Lajoie, Alexandre Valayer, Alexandre Valayer, Christophe Arnoult, Christophe Arnoult, Marie-Véronique Demattéi, Marie-Véronique Demattéi, Delphine Fouquenet, Delphine Fouquenet, Christelle Parent, Christelle Parent, Nathalie Heuzé-Vourc'h, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +23 more
doaj   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon   +25 more
doaj   +1 more source

Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes

Frontiers in Immunology
The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz, Katrien Vanderheyden, Yad Galaly, Simon Feldhoff, Magdalena Sips, Maximilian Brinkhaus, Ritva Tikkanen   +6 more
doaj   +1 more source