Results 51 to 60 of about 6,140 (133)
FcRN receptor antagonists in the management of myasthenia gravis
Frontiers in Neurology, 2023 Myasthenia gravis (MG) is an autoimmune disorder characterized by autoantibodies specifically directed against proteins located within the postsynaptic membrane of the neuromuscular junction.
Vinaya Bhandari, Vera Bril
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.All biotherapeutics have the potential to induce an immunogenic response and generate anti‐drug antibodies (ADAs), especially when administered as multiple doses over prolonged periods. However, a clinically meaningful effect of ADAs can be difficult to identify to communicate the impact of immunogenicity on drug exposure, safety and efficacy outcomes ...
Susan Richards +13 more
wiley +1 more source
Biomedicines, 2020 Conjugation of serum albumin or one of its ligands (such as fatty acid) has been an effective strategy to prolong the serum half-lives of drugs via neonatal Fc receptor (FcRn)–mediated recycling of albumin.
Jinhwan Cho +4 more
doaj +1 more source
iMeta, EarlyView.Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang +17 more
wiley +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Efanesoctocog alfa is a first‐in‐class high‐sustained factor VIII (HSF) replacement therapy for treatment of hemophilia A. This article presents population pharmacokinetics (PopPK) of efanesoctocog alfa and repeated time‐to‐event (RTTE) analysis of bleeding episodes in adults/adolescents (≥12 years of age) and children (<12 years).
Nancy Wong +7 more
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a ‘maternal‐foetal rejection’ mechanism, because at least some CHI cases fulfil the criteria for antibody‐mediated ...
Léonie Albersammer +18 more
wiley +1 more source
Fully Convolutional Recurrent Network for Handwritten Chinese Text Recognition [PDF]
arXiv, 2016 This paper proposes an end-to-end framework, namely fully convolutional recurrent network (FCRN) for handwritten Chinese text recognition (HCTR). Unlike traditional methods that rely heavily on segmentation, our FCRN is trained with online text data directly and learns to associate the pen-tip trajectory with a sequence of characters.
arxiv
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT In 2017, the free and open‐source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into a diverse network of stakeholders committed to advancing open‐source solutions for model‐informed drug development (MIDD). In this context, the first OSP Community Conference was hosted by Novartis in
André Dallmann +31 more
wiley +1 more source
PLoS ONE, 2023 Podocytes are key to preventing the filtration of serum proteins into the urine. Recent evidence also suggests that in immune mediated kidney diseases, podocytes are the targets of immune complexes (ICs).
George Haddad +4 more
doaj +1 more source
Depth Estimation on Underwater Omni-directional Images Using a Deep Neural Network [PDF]
arXiv, 2019 In this work, we exploit a depth estimation Fully Convolutional Residual Neural Network (FCRN) for in-air perspective images to estimate the depth of underwater perspective and omni-directional images. We train one conventional and one spherical FCRN for underwater perspective and omni-directional images, respectively.
arxiv