Results 51 to 60 of about 10,163 (201)

The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors

Therapeutic Advances in Neurological Disorders, 2021
The neonatal Fc receptor (FcRn) binds endogenous IgG and protects it from lysosomal degradation by transporting it back to the cell surface to re-enter the circulation, extending the serum IgG life span.
M. Dalakas, P. Spaeth
semanticscholar   +1 more source

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

Frontiers in Immunology, 2018
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth.
Diana Cadena Castaneda, Diana Cadena Castaneda, Christine Dhommée, Christine Dhommée, Thomas Baranek, Thomas Baranek, Emilie Dalloneau, Emilie Dalloneau, Laurie Lajoie, Laurie Lajoie, Alexandre Valayer, Alexandre Valayer, Christophe Arnoult, Christophe Arnoult, Marie-Véronique Demattéi, Marie-Véronique Demattéi, Delphine Fouquenet, Delphine Fouquenet, Christelle Parent, Christelle Parent, Nathalie Heuzé-Vourc'h, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart, Valérie Gouilleux-Gruart   +23 more
doaj   +1 more source

Decoupling FcRn and Tumor Contributions to Elevated Immune Checkpoint Inhibitor Clearance in Cancer Cachexia.

Pharmacological Research, 2023
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients.
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C Remaily, Emma J Montgomery, T. Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, A. Castillo, Samuel K Kulp, Xiaokui Mo, S. Nimmagadda, Paul Gregorevic, Dwight H Owen, Latha P. Ganesan, Thomas A Mace, Christopher C. Coss, Mitch A Phelps   +20 more
semanticscholar   +1 more source

FcRn, a critical regulator of antibody pharmacokinetics

Folia Pharmacologica Japonica, 2010
腫瘍や自己免疫疾患等の治療を目的とした分子標的薬として，抗体医薬品の研究開発が国内外で活発に行われている．抗体医薬品の特徴は標的分子に高い親和性をもって極めて特異的に結合することであるが，他のバイオ医薬品と比較して血中半減期が長いことも特筆すべき点である．ペプチドあるいはタンパク質を医薬品として応用する場合には血中半減期が実用化のためのハードルとなることが少なくない．しかし，多くの抗体医薬品は，生体内IgGの分解抑制に関わるneonatal Fc receptor（FcRn）を介したリサイクリング機構を利用することができるため，数日～数週間という長い血中半減期を有している．FcRnは齧歯類の新生児小腸に高発現し，乳汁に含まれる母親由来IgGの吸収に関与する受容体として同定された．その後の研究により ...
Akiko, Ishii-Watabe, Takuo, Suzuki, Minoru, Tada, Toru, Kawanishi, Teruhide, Yamaguchi, Nana, Kawasaki   +5 more
openaire   +3 more sources

Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes

Frontiers in Immunology
The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn blockade results in a reduction of autoantibodies
Anna Zakrzewicz, Katrien Vanderheyden, Yad Galaly, Simon Feldhoff, Magdalena Sips, Maximilian Brinkhaus, Ritva Tikkanen   +6 more
doaj   +1 more source

Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders

Frontiers in Immunology, 2022
Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma oncotic pressure and regulates the distribution of vascular fluid and has a range of other important functions.
E. Ward, D. Gelinas, E. Dreesen, Jolien Van Santbergen, J. Andersen, N. Silvestri, J. Kiss, D. Sleep, D. Rader, J. Kastelein, Els Louagie, G. Vidarsson, I. Spriet   +12 more
semanticscholar   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
Céline Monnet, Emilie Jacque, Christophe de Romeuf, Alexandre Fontayne, Toufik Abache, Nathalie Fournier, Gilles Dupont, Delphine Derache, Anais Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, Nicholas Masiello, Laetitia Danino, Michel Nogre, Anais Raia, Frederic Dhainaut, Louis Fauconnier, Dieudonnée Togbe, Carmen Reitinger, Falk Nimmerjahn, Wil Stevens, Sami Chtourou, Philippe Mondon   +25 more
doaj   +1 more source

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, E. Pannecoucke, Elvera J. van der Kooi, A. Bentlage, N. Derksen, Julie Andries, B. Balbino, M. Sips, P. Ulrichts, P. Verheesen, H. de Haard, T. Rispens, S. Savvides, G. Vidarsson   +13 more
semanticscholar   +1 more source

Pharmacokinetic Models for FcRn-Mediated IgG Disposition [PDF]

Journal of Biomedicine and Biotechnology, 2012
The objectives were to review available PK models for saturable FcRn-mediated IgG disposition, and to explore an alternative semimechanistic model. Most available empirical and mechanistic PK models assumed equal IgG concentrations in plasma and endosome in addition to other model-specific assumptions.
openaire   +2 more sources

FcRn is mother’s milk to allergen tolerance [PDF]

Journal of Experimental Medicine, 2017
In this issue Ohsaki et al. (https://doi.org/10.1084/jem.20171163) explain how breastfeeding can prevent the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (FcRn)–mediated transfer and uptake of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic cells (DCs).
openaire   +2 more sources