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Gene-specific somatic epigenetic mosaicism of FDFT1 underlies a non-hereditary localized form of porokeratosis (審査報告)

Gene-specific somatic epigenetic mosaicism of FDFT1 underlies a non-hereditary localized form of porokeratosis (審査報告)
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Characterization of Farnesyl Diphosphate Farnesyl Transferase 1 ( FDFT1 ) Expression In Cancer

Personalized Medicine, 2018
To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer.
Tüzmen, Şükrü, Hostetter, Galen, Watanabe, Aprill, Ekmekçi, Cumhur, Carrigan, Patricia E., Shechter, Ishaiahu, Kallioniemi, Olli, Miller, Laurence J., Mousses, Spyro   +8 more
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20(S)-Rg3 upregulates FDFT1 via reducing miR-4425 to inhibit ovarian cancer progression

Archives of Biochemistry and Biophysics, 2020
We previously found that ginsenoside 20(S)-Rg3 diminishes the proliferative and invasive capacities of ovarian cancer cells by decreasing miR-4425 level. Yet the mechanism of action of miR-4425 in ovarian cancer remains unclear. Here we report that miR-4425 is upregulated in ovarian cancer tissues relative to normal ovarian tissues, and transfection of
Jiaojiao, Lu, Yuanyuan, Zhou, Xia, Zheng, Lihong, Chen, Xiaoqian, Tuo, Hong, Chen, Mei, Xue, Qian, Chen, Wei, Chen, Xu, Li, Le, Zhao   +10 more
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Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury

Genes & Genomics, 2020
The acute hypoxic injury caused by the plain population entering the plateau in a short period of time has become the main cause of endangering the health of the people who rush into the plateau.The study aimed to identify the key genes which participate in resisting the acute hypoxic injury in SD Rats by transcriptomic profile analysis.48 Sprague ...
Xue, Lin, Haiyan, Wang, Xiaoyan, Pu
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FDFT1 repression by piR-39980 prevents oncogenesis by regulating proliferation and apoptosis through hypoxia in tongue squamous cell carcinoma

Life Sciences, 2023
Tongue squamous cell carcinoma (TSCC) is one of the most aggressive tumors whose underlying molecular mechanism remains elusive. Previous studies have identified piR-39980, a non-coding RNA, as a tumour suppressor or oncogene in different malignancies and the cholesterogenic protein, Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) playing critical ...
Trisha, Chattopadhyay, Bibekanand, Mallick   +1 more
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Exclusion of CTSB and FDFT1 as positional and functional candidate genes for keratolytic winter erythema (KWE)

Journal of Dermatological Science, 2012
Keratolytic winter erythema (KWE) or Oudtshoorn skin disease is a rare autosomal dominant monogenic disorder of epidermal keratinisation characterized clinically by cyclical peeling of the palms and soles. Due to a founder effect many KWE families have been identified in South Africa and the gene has been localized to 8p23.1-22, but the causal gene has
Angela, Hobbs, Shaun, Aron, Sian, Hartshorne, Peter R, Hull, Michèle, Ramsay   +4 more
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Spectroscopic diagnosis and metabolite characterization of cisplatin resistance regulated by FDFT1 in bladder cancer tissue

Applied Radiation and Isotopes
As is the case for most solid tumours, chemotherapy remains the backbone in the management of metastatic disease. However, the occurrence of chemotherapy resistance is a cause to worry, especially in bladder cancer. Extensive evidence indicates molecular changes in bladder cancer cells to be the underlying cause of chemotherapy resistance, including ...
M. Kanmalar, Raihan Kamal, S.F. Abdul Sani, Dharini Pathmanathan, Nur Akmarina Bm Said, Yogaambikai Paramanantham, Amira Hajirah Abd Jamil, K.S. Mun, S. Kuppusamy, K.S. Almugren, Hadeel F. Almajid, D.A. Bradley   +11 more
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Association between FDFT1 gene polymorphism and postmenopausal osteoporosis

Panminerva Medica, 2021
Liang, He, Shenjin, Wang, Wei, Kong
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Identification of Ferroptosis-Related Prognostic Models and FDFT1 as a Potential Ferroptosis Driver in Colorectal Cancer

Current Medicinal Chemistry
Aims: We aimed to develop Ferroptosis-Related Gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with colorectal cancer (CRC). Background: Prediction of CRC prognosis is ...
Lili, Duan, Lu, Cao, Jinqiang, Liu, Zixiang, Wang, Jie, Liang, Fan, Feng, Jian, Zhang, Liu, Hong, Jianyong, Zheng   +8 more
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MicroRNA-146b-5p/FDFT1 mediates cisplatin sensitivity in bladder cancer by redirecting cholesterol biosynthesis to the non-sterol branch

The International Journal of Biochemistry & Cell Biology
Chemotherapy against muscle-invasive bladder cancer is increasingly challenged by the prevalence of chemoresistance. The cholesterol biosynthesis pathway has garnered attention in studies of chemoresistance, but conflicting clinical and molecular findings necessitate a clearer understanding of its underlying mechanisms. Recently, we identified farnesyl-
Nurul Amniyyah Azhar, Yogaambikai Paramanantham, W M Farhan Syafiq B W M Nor, Nur Akmarina B. M. Said   +3 more
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