Results 41 to 50 of about 179,106 (262)

The NMR contribution to protein–protein networking in Fe–S protein maturation [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2018
Iron-sulfur proteins were among the first class of metalloproteins that were actively studied using NMR spectroscopy tailored to paramagnetic systems. The hyperfine shifts, their temperature dependencies and the relaxation rates of nuclei of cluster-bound residues are an efficient fingerprint of the nature and the oxidation state of the Fe-S cluster ...
Banci L., Camponeschi F., Ciofi-Baffoni S., Piccioli M.   +3 more
openaire   +3 more sources

Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease

Cells, 2019
The formation of cytotoxic intracellular protein aggregates is a pathological signature of multiple neurodegenerative diseases. The principle aggregating protein in Parkinson’s disease (PD) and atypical Parkinson’s diseases is α ...
Fleur A. McLeary, Alexandre N. Rcom-H’cheo-Gauthier, Michael Goulding, Rowan A. W. Radford, Yuho Okita, Peter Faller, Roger S. Chung, Dean L. Pountney   +7 more
doaj   +1 more source

Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin. [PDF]

PLoS ONE, 2013
Human serum albumin (HSA), the most abundant protein in human plasma, could be considered as a prototypic monomeric allosteric protein, since the ligand-dependent conformational adaptability of HSA spreads beyond the immediate proximity of the binding ...
Alessio Bocedi, Giampiero De Sanctis, Chiara Ciaccio, Grazia R Tundo, Alessandra Di Masi, Gabriella Fanali, Francesco P Nicoletti, Mauro Fasano, Giulietta Smulevich, Paolo Ascenzi, Massimo Coletta   +10 more
doaj   +1 more source

Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes

Poultry Science, 2022
: Osteocalcin (OCN) has a function in preventing fatty liver hemorrhagic syndrome (FLHS) in poultry. The aim of this study was to investigate the effects of OCN on fat emulsion stimulated chicken embryonic hepatocytes and related signaling pathways.
M. Zhang, W.J. Tu, Q. Zhang, X.L. Wu, X.Y. Zou, S. Jiang   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Atypical Iron-Sulfur Cluster Binding, Redox Activity and Structural Properties of Chlamydomonas reinhardtii Glutaredoxin 2

Antioxidants, 2021
Glutaredoxins (GRXs) are thioredoxin superfamily members exhibiting thiol-disulfide oxidoreductase activity and/or iron-sulfur (Fe-S) cluster binding capacities. These properties are determined by specific structural factors.
Thomas Roret, Bo Zhang, Anna Moseler, Tiphaine Dhalleine, Xing-Huang Gao, Jérémy Couturier, Stéphane D. Lemaire, Claude Didierjean, Michael K. Johnson, Nicolas Rouhier   +9 more
doaj   +1 more source

A New Method To Image Heme-Fe, Total Fe, and Aggregated Protein Levels after Intracerebral Hemorrhage [PDF]

ACS Chemical Neuroscience, 2015
An intracerebral hemorrhage (ICH) is a devastating stroke that results in high mortality and significant disability in survivors. Unfortunately, the underlying mechanisms of this injury are not yet fully understood. After the primary (mechanical) trauma, secondary degenerative events contribute to ongoing cell death in the peri-hematoma region ...
Hackett, Mark, Desouza, M., Caine, S., Bewer, B., Nichol, H., Paterson, P., Colbourne, F.   +6 more
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Thigh muscle metabolic response is linked to feed efficiency and meat characteristics in slow-growing chicken

Poultry Science, 2023
: The Korat chicken (KR) is a slow-growing Thai chicken breed with relatively poor feed efficiency (FE) but very tasty meat with high protein and low fat contents, and a unique texture.
Pramin Kaewsatuan, Chotima Poompramun, Satoshi Kubota, Jirawat Yongsawatdigul, Wittawat Molee, Pekka Uimari, Amonrat Molee   +6 more
doaj   +1 more source