Results 51 to 60 of about 179,106 (262)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Concentration-dependent effect of norfloxacin on iron toxicity in the intestine of large yellow croaker Larimichthys crocea (Richardson, 1846)

Frontiers in Marine Science
This study explores the effects of norfloxacin (NOR) on oxidative damage, iron (Fe) transport, energy metabolism, and immunotoxicity in the intestine of large yellow croaker under Fe stress.
Lin Zeng, Yong-Hong Wang, Chun-Xiang Ai, Bin Liu, Bin Liu, Min-Hui Yu, Hui Zhang, Fei Li   +7 more
doaj   +1 more source

Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral [PDF]

Proceedings of the National Academy of Sciences, 2003
Iron is concentrated in ferritin, a spherical protein with a capacious cavity for ferric nanominerals of <4,500 Fe atoms. Global ferritin structure is very stable, resisting 6 M urea and heat (85°C) at neutral pH. Eight pores, each formed by six helices from 3 of the 24 polypeptide subunits, restrict mineral access to reductant,
Xiaofeng, Liu, Weili, Jin, Elizabeth C, Theil   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8

eLife, 2021
Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts; however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import
Hsiang-Chun Chang, Jason Solomon Shapiro, Xinghang Jiang, Grant Senyei, Teruki Sato, Justin Geier, Konrad T Sawicki, Hossein Ardehali   +7 more
doaj   +1 more source

Fe/S protein biogenesis in trypanosomes — A review

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015
Trypanosoma brucei, the causative agent of the African sleeping sickness of humans, and other kinetoplastid flagellates belong to the eukarytotic supergroup Excavata. This early-branching model protist is known for a broad range of unique features. As it is amenable to most techniques of forward and reverse genetics, T.
Lukeš, Julius, Basu, Somsuvro
openaire   +2 more sources

Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein. [PDF]

Molecular and Cellular Biology, 1985
The avian c-fps and mammalian c-fes proto-oncogenes are cognate cellular sequences. Antiserum raised against the P140gag-fps transforming protein of Fujinami avian sarcoma virus specifically recognized a 92,000-Mr protein in human and mouse hematopoietic cells which was closely related in structure to Snyder-Theilen feline sarcoma virus P87gag-fes ...
I, MacDonald, J, Levy, T, Pawson
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Association of Mitochondrial Function and Feed Efficiency

The Journal of Poultry Science, 2007
Studies were conducted to evaluate the potential link between mitochondrial function and biochemistry with the phenotypic expression of feed efficiency (FE) in a single line of broilers fed the same diet.
Carolyn P. Ojano-Dirain, Neil R. Pumford, Masaaki Toyomizu, Walter G. Bottje   +3 more
doaj   +1 more source

An essential role for an Fe-S cluster protein in the cytochrome c oxidase complex of Toxoplasma parasites.

PLoS Pathogens, 2023
The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs considerably from the ETC of the animals that these parasites infect, and is the target of numerous anti-parasitic drugs.
Rachel A Leonard, Yuan Tian, Feng Tan, Giel G van Dooren, Jenni A Hayward   +4 more
doaj   +1 more source