Scientific Reports, 2017 Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA).
Aniruddha Das +3 more
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Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.
PLoS ONE, 2012 Memory loss is one of the hallmark symptoms of Alzheimer's disease (AD). It has been proposed that soluble amyloid-beta (Abeta) oligomers acutely impair neuronal function and thereby memory.
Kara A Kittelberger +3 more
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mGluR5 in amygdala modulates fear memory generalization
Frontiers in Behavioral Neuroscience, 2023 IntroductionFear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear.
Shou-Min Xuan +11 more
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Frontiers in Molecular Neuroscience, 2015 Rac1, a member of the Rho family of small GTPases, is crucial for morphological changes of the mature neuronal synapse including spine formation and activity-dependent spine enlargement, while its role in the formation of associated memories, such as ...
Qinqin eGao +8 more
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Sexually divergent expression of active and passive conditioned fear responses in rats
eLife, 2015 Traditional rodent models of Pavlovian fear conditioning assess the strength of learning by quantifying freezing responses. However, sole reliance on this measure includes the de facto assumption that any locomotor activity reflects an absence of fear ...
Tina M Gruene +4 more
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Role of TRPC6 in conditioning and extinction of contextual fear memory in mice
Di-san junyi daxue xuebao, 2020 Objective To explore the role of transient receptor potential canonical 6 (TRPC6) on conditioning and extinction in contextual fear memory. Methods A total of 32 male C57BL/6J mice (6~8 weeks old) were randomized into fear conditioning (Cond group, n=16)
TIAN Yiqin +4 more
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NR2A- and NR2B-containing NMDA Receptors in the Prelimbic Medial Prefrontal Cortex Differentially Mediate Trace, Delay, and Contextual Fear Conditioning [PDF]
, 2013 Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association ...
Gilmartin, Marieke R. +2 more
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Fear Conditioning Assay in Mouse
Bio-Protocol, 2013 The study of fear memory is important for understanding various anxiety disorders in which patients experience persistent recollections of traumatic events.
Melissa Wang, Isabel Muzzio
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Not all stressors are equal : behavioral and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilization [PDF]
, 2012 Exposure of animals to footshocks (FS) in absence of any specific cue results in the development of fear to the compartment where shocks were given (contextual fear conditioning), and this is usually evaluated by time spent freezing.
Armario, Antonio +3 more
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Putting fear in its place: remapping of hippocampal place cells during fear conditioning [PDF]
, 2004 We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment.
Blair, HT +4 more
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