Results 61 to 70 of about 234,528 (304)

Plasticity of fear and safety neurons of the amygdala in response to fear extinction

Frontiers in Behavioral Neuroscience, 2015
Fear inhibition learning induces plasticity and remodeling of circuits within the amygdala. Most studies examine these changes in nondiscriminative fear conditioning paradigms.
Susan eSangha, Susan eSangha
doaj   +1 more source

The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. [PDF]

, 2009
Synaptic plasticity in the amygdala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region.
Cook, James M, Fanselow, Michael S, Godsil, Bill P, Homanics, Gregg E, Houser, Carolyn R, June, Harry L, Linn, Michael L Van, O'Dell, Tom J, Peng, Zechun, Saab, Faysal, Wiltgen, Brian J   +10 more
core  

Don't fear 'fear conditioning'

Neuroscience and Biobehavioral Reviews, 2017
The so-called 'replicability crisis' has sparked methodological discussions in many areas of science in general, and in psychology in particular. This has led to recent endeavours to promote the transparency, rigour, and ultimately, replicability of research.
Lonsdorf, Tina B., Menz, Mareike M., Andreatta, Marta, Fullana, Miguel A., Golkar, Armita, Haaker, Jan, Heitland, Ivo, Hermann, Andrea, Kuhn, Manuel, Kruse, Onno, Meir Drexler, Shira, Meulders, Ann, Nees, Frauke, Pittig, Andre, Richter, Jan, Römer, Sonja, Shiban, Youssef, Schmitz, Anja, Straube, Benjamin, Vervliet, Bram, Wendt, Julia, Baas, Johanna M.P., Merz, Christian J.   +22 more
openaire   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning [PDF]

, 2015
The basolateral and lateral amygdala nuclei complex (BLC) is implicated in a number of emotional responses including conditioned fear and social anxiety.
Arendt, Dave, Bernabe, Cristian, Deehan, Gerald A., Engleman, Eric A., Federici, Lauren M., Fitz, Stephanie D., Johnson, Philip L., Lowry, Christopher A., Molosh, Andrei, Rodd, Zachary A., Shekhar, Anantha   +10 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Learning strategies during fear conditioning [PDF]

Neurobiology of Learning and Memory, 2009
This paper describes a model of fear learning, in which subjects have an option of behavioral responses to impending social defeat. The model generates two types of learning: social avoidance and classical conditioning, dependent upon (1) escape from or (2) social subordination to an aggressor. We hypothesized that social stress provides the impetus as
Russ E, Carpenter, Cliff H, Summers
openaire   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes

Frontiers in Behavioral Neuroscience, 2014
Maladaptive fear, such as fear that is persistent or easily generalized to a nonthreatening stimuli, is associated with anxiety-related disorders in humans. In the laboratory, maladaptive fear can be modeled in rodents using Pavlovian fear conditioning.
Stephanie J Temme, Ryan Z Bell, Reciton ePahumi, Geoffrey G Murphy, Geoffrey G Murphy, Geoffrey G Murphy   +5 more
doaj   +1 more source

Arc expression identifies the lateral amygdala fear memory trace [PDF]

, 2015
Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons within a memory trace remain incompletely understood. Using a fluorescence-based Arc reporter, we were able to visually identify the
Elgersma, Y. (Ype), Gouty-Colomer, L.A., Hosseini, B., Houweling, A.R. (Arthur), Jaarsma, D., Kushner, S.A. (Steven), Marcelo, I.M., Schreiber, J. (Jadwiga), Slump, D.E. (Denise E.), Yamaguchi, S.   +9 more
core   +3 more sources