AIChE Journal, Volume 72, Issue 5, May 2026.Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto +6 more
wiley +1 more source
Recombinant Fibrinogen‐Gamma‐Chain as a Crosslinker of Thiol‐ene Hydrogels
Biopolymers, Volume 117, Issue 3, May 2026.Fibrinogen gamma chain (FGG) was recombinantly expressed in E. coli to generate a recombinant protein containing free thiol groups from cysteine. The expressed protein was used to crosslink norbornene functionalized gelatin providing a proof‐of‐principle of this novel crosslinker type and the formed hydrogels were characterized for their stiffness ...
Domenic Schlauch +5 more
wiley +1 more source
Cometabolic regulation of glucose and glycerol to enhance 1,3-propanediol yield by Clostridium butyricum. [PDF]
Microb Cell FactWang L, Sun Y, Xiu Z.
europepmc +1 more source
Journal of Chemometrics, Volume 40, Issue 5, May 2026.ABSTRACT This study demonstrates a robust chemometric framework for high‐throughput compositional analysis of lignocellulosic biomass using a portable near‐infrared (NIR) spectrometer. Sugarcane bagasse solids produced by pressurized solvent fractionation (PSF) under batch and continuous conditions were analyzed to predict cellulose, hemicellulose, and
Julia M. M. Caetano +7 more
wiley +1 more source
3D‐Printed Coil Immobilized Enzyme Reactors for Laccase Biocatalysis in Single‐ and Two‐Phase Flow
Chemie Ingenieur Technik, Volume 98, Issue 5, Page 212-223, May 2026.Development of 3D‐printed immobilized enzyme reactors functionalized with laccase for continuous‐flow biocatalysis. Surface coupling and reactor design enhanced stability and mass transfer, enabling efficient and reusable biocatalytic processes.
Alina J. Tauriainen +4 more
wiley +1 more source
Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein
Chemistry–Methods, Volume 6, Issue 5, May 2026.The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley +4 more
wiley +1 more source
Benzylisoquinoline Alkaloid Production in Yeast via Norlaudanosoline Improves Titer, Selectivity, and Yield. [PDF]
ACS Synth BiolNarcross L +5 more
europepmc +1 more source
Nanobiocatalysts: Potential Applications in Biofuel Production and Biotransformation
Carbon Neutralization, Volume 5, Issue 3, May 2026.The application of nanobiocatalysts in the field of biofuel production and the biotransformation of substrate were reviewed. Further, the possible research gaps in the field of biofuel and value‐added compound production and a possible way to enhance the application of nanobiocatalyst in future development are highlighted.
Preethi Muthu +4 more
wiley +1 more source
Multistep metabolic engineered <i>Klebsiella oxytoca</i> for efficient l-leucine production. [PDF]
Synth Syst BiotechnolSun W +14 more
europepmc +1 more source
Multivariate Curve Resolution and Carbon Balance Constraint to Unravel FTIR Spectra from Fed-Batch Fermentation Samples. [PDF]
Bioengineering (Basel), 2017 Vier D +3 more
europepmc +1 more source